Xuming Dai
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View article: Erianin mitigates diabetic cardiomyopathy <i>via</i> adenosine monophosphate-activated protein kinase-nuclear factor erythroid 2-related factor 2-heme oxygenase-1 pathway activation
Erianin mitigates diabetic cardiomyopathy <i>via</i> adenosine monophosphate-activated protein kinase-nuclear factor erythroid 2-related factor 2-heme oxygenase-1 pathway activation Open
BACKGROUND Erianin is a natural bibenzyl compound extracted from Dendrobium chrysotoxum and is known for its anti-inflammatory and antioxidant properties. AIM To explore the possible therapeutic mechanisms of erianin and determine if it ca…
View article: A Quality Improvement Program for Recognition and Treatment of Inpatient ST-Segment Elevation Myocardial Infarctions
A Quality Improvement Program for Recognition and Treatment of Inpatient ST-Segment Elevation Myocardial Infarctions Open
or thrombolytic therapy is the standard of care for STsegment elevation myocardial infarction (STEMI). STEMIs that occur in hospitalized patients have delayed symptom recognition, longer times from electrocardiography (ECG) to firstdevice …
View article: A machine learning model in predicting hemodynamically significant coronary artery disease: A prospective cohort study
A machine learning model in predicting hemodynamically significant coronary artery disease: A prospective cohort study Open
Machine learning models based on routine demographics, clinical factors, and lab data can be used to predict hemodynamically significant CAD with accuracy that approximates current noninvasive functional modalities.
View article: Automatic Identification of the End-Diastolic and End-Systolic Cardiac Frames from Invasive Coronary Angiography Videos
Automatic Identification of the End-Diastolic and End-Systolic Cardiac Frames from Invasive Coronary Angiography Videos Open
Automatic identification of proper image frames at the end-diastolic (ED) and end-systolic (ES) frames during the review of invasive coronary angiograms (ICA) is important to assess blood flow during a cardiac cycle, reconstruct the 3D art…
View article: Prognostic value of shock index in patients admitted with non-ST-segment elevation myocardial infarction: the ARIC study community surveillance
Prognostic value of shock index in patients admitted with non-ST-segment elevation myocardial infarction: the ARIC study community surveillance Open
Aims Shock index (SI), defined as the ratio of heart rate (HR) to systolic blood pressure (SBP), is easily obtained and predictive of mortality in patients with ST-segment elevation myocardial infarction. However, large-scale evaluations o…
View article: Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging
Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging Open
As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound tr…
View article: Assessment of thirty‐day readmission rate, timing, causes and predictors after hospitalization with COVID‐19
Assessment of thirty‐day readmission rate, timing, causes and predictors after hospitalization with COVID‐19 Open
Background There are limited data on the characteristics of 30‐day readmission after hospitalization with coronavirus disease 2019 (COVID‐19). Objectives To examine the rate, timing, causes, predictors and outcomes of 30‐day readmission af…
View article: Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study Open
Background Acute myocardial infarction (AMI) with in‐hospital onset (AMI‐IHO) has poor prognosis but is clinically underappreciated. Whether its occurrence has changed over time is uncertain. Methods and Results Since 1987, the ARIC (Ather…
View article: Delayed Treatment of Acute Myocardial Infarction With Ventricular Septal Rupture Due to Patient Fear During the COVID-19 Pandemic
Delayed Treatment of Acute Myocardial Infarction With Ventricular Septal Rupture Due to Patient Fear During the COVID-19 Pandemic Open
During the coronavirus disease 2019 (COVID-19) pandemic, more patients are presenting with complications late after acute myocardial infarction. We report the case of a 71-year-old man who delayed seeking medical care for 2 weeks, despite …
View article: A Systematic Approach to Evaluate Patients Presenting With ST-Segment Elevation in Lead aVR: A Case Series
A Systematic Approach to Evaluate Patients Presenting With ST-Segment Elevation in Lead aVR: A Case Series Open
ST-segment elevation (STE) in the lead aVR indicates global ischemia of the myocardium and is often associated with obstructive coronary artery disease (CAD). We report a serial of cases presenting with STE in aVR and diffuse ST depression…
View article: Mortality differences among patients with i<scp>n‐hospital ST‐elevation</scp> myocardial infarction
Mortality differences among patients with i<span>n‐hospital ST‐elevation</span> myocardial infarction Open
Background In‐hospital ST‐elevation myocardial infarction (STEMI) is associated with a higher mortality rate than out‐of‐hospital STEMI. Quality measures and universal protocols for treatment of in‐hospital STEMI do not exist, likely contr…
View article: Association of Inpatient vs Outpatient Onset of ST-Elevation Myocardial Infarction With Treatment and Clinical Outcomes
Association of Inpatient vs Outpatient Onset of ST-Elevation Myocardial Infarction With Treatment and Clinical Outcomes Open
Reperfusion times for ST elevation myocardial infarction (STEMI) occurring in outpatients have improved significantly, but quality improvement efforts have largely ignored STEMI occurring in hospitalized patients (inpatient-onset STEMI).
View article: Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation
Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation Open
Collaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass vessels when the trunk of one tree becomes narrowed by vascular disease. The number…
View article: Endothelial Nitric Oxide Synthase Deficiency Causes Collateral Vessel Rarefaction and Impairs Activation of a Cell Cycle Gene Network During Arteriogenesis
Endothelial Nitric Oxide Synthase Deficiency Causes Collateral Vessel Rarefaction and Impairs Activation of a Cell Cycle Gene Network During Arteriogenesis Open
The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology.
View article: Intra-procedural arrhythmia during cardiac catheterization: A systematic review of literature
Intra-procedural arrhythmia during cardiac catheterization: A systematic review of literature Open
Cardiac arrhythmias are common and potentially serious complications of cardiac catheterization procedures, and it demands constant vigilance and readiness to intervene during procedures.
View article: The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis
The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis Open
Proteins responsible for Pi homeostasis are critical for all life. In Saccharomyces cerevisiae, extracellular [Pi] is “sensed” by the inositol-hexakisphosphate kinase (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-dipho…
View article: Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis Open
Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improv…
View article: Stable ischemic heart disease in the older adults
Stable ischemic heart disease in the older adults Open
Ischemic heart disease is caused by atherosclerotic and/or thrombotic obstruction of coronary arteries. Clinical spectrum of ischemic heart disease expands from asymptomatic atherosclerosis of coronary arteries to acute coronary syndromes …
View article: Acute coronary syndrome in the older adults
Acute coronary syndrome in the older adults Open
Coronary heart disease remains the leading cause of death in the developed world. Advanced age is the single strongest risk factor for coronary artery disease (CAD) and independent predictor for poor outcomes following an acute coronary sy…
View article: Plaque herniation after stenting the culprit lesion with myocardial bridging in ST elevation myocardial infarction: A case report
Plaque herniation after stenting the culprit lesion with myocardial bridging in ST elevation myocardial infarction: A case report Open
Plaque herniation or prolapse after stenting a MB segment in STEMI is a potential etiology for acute stent failure.
View article: Cardiac implications of thrombotic thrombocytopenic purpura
Cardiac implications of thrombotic thrombocytopenic purpura Open
Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on platelet-mediated micro-th…
View article: MicroRNA-21 mediates high phosphate-induced endothelial cell apoptosis
MicroRNA-21 mediates high phosphate-induced endothelial cell apoptosis Open
Hyperphosphatemia, the elevated level of inorganic phosphate (Pi) in serum, is associated with increased cardiovascular morbidities and mortality. The effects of high Pi on endothelial cells are not well studied. This study investigated hi…