Xiaojing Zhao
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View article: The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner
The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner Open
View article: Assessment of eHealth literacy among cardiovascular disease patients and analysis of influencing factors
Assessment of eHealth literacy among cardiovascular disease patients and analysis of influencing factors Open
Objective This study aimed to comprehensively evaluate the eHealth literacy of patients with cardiovascular diseases and uncover the associated influencing factors. The findings are intended to lay a solid foundation for formulating target…
View article: Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease
Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease Open
Background Intestinal fibrosis is a serious complication of Crohn’s disease (CD), often resulting from chronic inflammation. However, the precise mechanisms through which inflammation induces intestinal fibrosis remain inadequately elucida…
View article: Abnormal Functional Network Centrality and Causal Connectivity in Migraine Without Aura: A Resting‐State fMRI Study
Abnormal Functional Network Centrality and Causal Connectivity in Migraine Without Aura: A Resting‐State fMRI Study Open
Objective The pathophysiological mechanism of migraine is still not clear. Thus, this study aimed to evaluate the changes in effective connectivity (EC) in the brain functional network underlying migraine and its association with clinical …
View article: Inflammatory Monocyte-Derived Amphiregulin Mediates Intestinal Fibrosis in Crohn's Disease by Activating PI3K/AKT
Inflammatory Monocyte-Derived Amphiregulin Mediates Intestinal Fibrosis in Crohn's Disease by Activating PI3K/AKT Open
View article: P174 Treg Cell and Human Intestinal Myofibroblast-Derived Amphiregulin induced by TGF-β Promotes Colitis-Associated Intestinal Fibrosis
P174 Treg Cell and Human Intestinal Myofibroblast-Derived Amphiregulin induced by TGF-β Promotes Colitis-Associated Intestinal Fibrosis Open
Background Intestinal fibrosis is one of the most threatening complications of Crohn’s disease (CD). Intestinal fibrosis is usually the result of chronic inflammation, and T cell response is the main driver of intestinal inflammation. At p…
View article: GPR120 promotes neutrophil control of intestinal bacterial infection
GPR120 promotes neutrophil control of intestinal bacterial infection Open
G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated the role of GPR120 in the regulation of neutrophil …
View article: Implementing caregiver management measures in general hospitals to prevent the <scp>COVID</scp>‐19 pandemic
Implementing caregiver management measures in general hospitals to prevent the <span>COVID</span>‐19 pandemic Open
Aim To summarize the whole process management measures for caregivers of inpatients in a non‐new coronavirus pneumonia designated hospital in China during the novel coronavirus pneumonia epidemic. The implementation of these measures is ma…
View article: Hydroxychloroquine ameliorates DSS-induced colitis by inhibiting M1 macrophage polarization through NF-κB/NLRP3 signaling pathway
Hydroxychloroquine ameliorates DSS-induced colitis by inhibiting M1 macrophage polarization through NF-κB/NLRP3 signaling pathway Open
Background and Aims: Polarization of macrophages to the M1 or M2 phenotype is critical for the development and occurrence of inflammation and disease. An increased proportion of M1-type macrophages has been observed in inflammatory bowel d…
View article: Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts
Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts Open
View article: Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis Open
Glucose, the critical energy source in the human body, is considered a potential risk factor in various autoimmune diseases when consumed in high amounts. However, the roles of glucose at moderate doses in the regulation of autoimmune infl…
View article: α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function
α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function Open
Background and aims Cholinergic output, which could modulate innate immune responses through stimulation of α7 nicotinic acetylcholine receptor (α7nAChR), might be a target to minimize tissue damage in autoimmune disease. GTS-21, a selecti…
View article: A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission
A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission Open
IBD-IBS patients may have low QOL and psychological abnormalities, as wells as visceral hypersensitivity which may be related to increased 5-HT and NGF levels released from activated mast cells.
View article: LncRNA LUCAT1 as a Plasma Biomarker for Assessing Disease Activity in Adult Patients with Crohn’s Disease
LncRNA LUCAT1 as a Plasma Biomarker for Assessing Disease Activity in Adult Patients with Crohn’s Disease Open
Aim. To explore the expression of long noncoding RNA (LncRNA) LUCAT1 in adult patients with Crohn’s disease (CD) and evaluate the relationship between LncRNA LUCAT1 and the disease activity in Chinese patients with CD. Methods. Patients wi…
View article: GPR120 Inhibits Colitis Through Regulation of CD4+ T Cell Interleukin 10 Production
GPR120 Inhibits Colitis Through Regulation of CD4+ T Cell Interleukin 10 Production Open
View article: Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair
Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Open
Our results demonstrate a mechanism by which propionate stimulates cell migration in an HDAC inhibition, GPR43, and STAT3 dependent manner, and suggest that propionate plays an important role in epithelial migration independent of prolifer…
View article: STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells
STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells Open
Stimulator of interferon genes (STING) has been shown to play a critical role in orchestrating immune responses to various pathogens through sensing cyclic dinucleotides. However, how STING regulates intestinal homeostasis is still not com…
View article: Glucagon‑like peptide‑1 analogue exendin‑4 modulates serotonin transporter expression in intestinal epithelial cells
Glucagon‑like peptide‑1 analogue exendin‑4 modulates serotonin transporter expression in intestinal epithelial cells Open
Serotonin‑selective reuptake transporter (SERT) regulates extracellular availability of serotonin (5‑hydroxytryptamine; 5‑HT) and participates in the pathogenesis of functional disorders. Colonic SERT expression is decreased in colonic sen…
View article: Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease
Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease Open
Intestinal microbiota dysbiosis has been described in inflammatory bowel disease (IBD), but data from China are limited. In this study, we performed molecular analysis of the fecal microbial community from 20 healthy Chinese subjects and 2…
View article: Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification
Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification Open
Yuemei Han,1,* Junmei Tang,1,* Jiayi Xia,1 Rui Wang,1 Chen Qin,1 Sihao Liu,1 Xia Zhao,1 Hao Chen,1,2 Quankui Lin1,2 1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, People’s …
View article: Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease
Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease Open
CD patients have a higher prevalence of food-specific IgG antibodies than UC patients and HCs. IBD patients are prone to rice, corn, tomato and soybean intolerance. Smoking may be a risk factor in the occurrence of food-specific IgG antibo…
View article: Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis
Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis Open
The clinical course of ulcerative colitis (UC) is featured by remission and relapse, which remains unpredictable. Recent studies revealed that fecal calprotectin (FC) could predict clinical relapse for UC patients in remission, which has n…
View article: Sa1758 – The Relationship Between Serum Bilirubin and Inflammatory Bowel Disease
Sa1758 – The Relationship Between Serum Bilirubin and Inflammatory Bowel Disease Open
View article: The Relationship between Serum Bilirubin and Inflammatory Bowel Disease
The Relationship between Serum Bilirubin and Inflammatory Bowel Disease Open
The associations between serum total bilirubin (sTB) levels, inflammatory marker levels, and disease activity are not well understood in patients with inflammatory bowel disease (IBD). The present study investigated the association between…
View article: Tranilast inhibits TGF-β-induced collagen gel contraction mediated by human corneal fibroblasts
Tranilast inhibits TGF-β-induced collagen gel contraction mediated by human corneal fibroblasts Open
Tranilast suppresses the HCFs-cultured collagen gel contraction induced by TGF-β. It attenuates actin stress fibers formation, focal adhesions, and the secretion of MMPs, with these actions likely contributing to the inhibitory effect on H…
View article: Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease
Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease Open
Our study profiles specific characteristics and microbial dysbiosis in the gut of Chinese patients with IBD. Bacteroidetes may have a negative impact on inflammatory development.
View article: P021 Aryl hydrocarbon receptor controls ILC3/ILC1 immunity in a colitis model of 2, 4,6-trinitrobenzene sulphonic acid
P021 Aryl hydrocarbon receptor controls ILC3/ILC1 immunity in a colitis model of 2, 4,6-trinitrobenzene sulphonic acid Open
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that controls the toxicity of dioxins and regulates the immune response. It has been generally established that the AHR plays an important physiological role in int…
View article: Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs
Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs Open
Bifico is a probiotic mixture containing Bifidobacterium , Lactobacillus acidophilus , and Enterococcus. Studies support that Bifico has a protective effect in experimental colitis (IL-10-deficient and TNBS) models and in patients with inf…
View article: Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis
Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis Open
Mucosal samples of inflamed descending colon from 14 active UC patients and 15 healthy subjects (HS) were analyzed by high-throughput sequencing to compare the fungal microbiota. The expressions of pro-inflammatory cytokines (IL-Iβ, TNF-α,…
View article: Efficacy and safety of rectal 5-aminosalicylic acid versus corticosteroids in active distal ulcerative colitis: a systematic review and network meta-analysis
Efficacy and safety of rectal 5-aminosalicylic acid versus corticosteroids in active distal ulcerative colitis: a systematic review and network meta-analysis Open