Xuqiang Liu
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View article: MST4 as a Key Driver of Osteoclast Activation in Osteoporosis
MST4 as a Key Driver of Osteoclast Activation in Osteoporosis Open
View article: Correction: Wang et al. The Inhibition of RANKL-Induced Osteoclastogenesis through the Suppression of p38 Signaling Pathway by Naringenin and Attenuation of Titanium-Particle-Induced Osteolysis. Int. J. Mol. Sci. 2014, 15, 21913–21934
Correction: Wang et al. The Inhibition of RANKL-Induced Osteoclastogenesis through the Suppression of p38 Signaling Pathway by Naringenin and Attenuation of Titanium-Particle-Induced Osteolysis. Int. J. Mol. Sci. 2014, 15, 21913–21934 Open
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View article: Exploring the active components and mechanism of Ziziphi Spinosae Semen in treating insomnia by network pharmacology and metabonomics
Exploring the active components and mechanism of Ziziphi Spinosae Semen in treating insomnia by network pharmacology and metabonomics Open
Insomnia, a sleep-disordered disease, is characterized by difficulty in falling asleep, decrease of sleep quality and sleep time, decline of memory and attention. Ziziphi Spinosae Semen (ZSS) is one of the important “medicine-food” herbs f…
View article: Protective effects of Pleurotus placentodes against liver injury in mice via the PTGS2, NR3C1 and PPARA signaling pathways
Protective effects of Pleurotus placentodes against liver injury in mice via the PTGS2, NR3C1 and PPARA signaling pathways Open
This study explored the active ingredients and mechanism of Pleurotus placentodes extract (PP-a) in alleviating acute liver injury. According to un-targeted metabolomics analysis, 102 compounds were identified in PP-a, 32 were regarded as …
View article: Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways
Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways Open
View article: Radiation Effects of Flexible Imm Triple Junction Solar Cell Under 14 Mev Neutron Irradiation
Radiation Effects of Flexible Imm Triple Junction Solar Cell Under 14 Mev Neutron Irradiation Open
View article: Comparison of Radiation Effects of Lm and Umm Structure Gaas Triple-Junction Solar Cells Under 1 Mev Neutron Irradiation
Comparison of Radiation Effects of Lm and Umm Structure Gaas Triple-Junction Solar Cells Under 1 Mev Neutron Irradiation Open
View article: Osteogenic and anti-osteoclastogenic properties of tannic acid-modified sodium alginate/chitosan microspheres for bone defect repair
Osteogenic and anti-osteoclastogenic properties of tannic acid-modified sodium alginate/chitosan microspheres for bone defect repair Open
Background: The traditional treatment methods for bone defects have many deficiencies. Recently, bone tissue engineering has played an increasingly important role in designing new grafts with tissue-inducing activity. In the body, bone res…
View article: Identification of several inflammation-related genes based on bioinformatics and experiments
Identification of several inflammation-related genes based on bioinformatics and experiments Open
LOXL1 and PTTG1 were highly expressed in some inflammation-related diseases, while that of REEP5 and CDC14B were almost unchanged. PTTG1 may be a potential target for the treatment of osteoarthritis.
View article: 3-Epi-betulinic acid 3- <i>O</i>- <i>β</i>- <i>D</i>-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma
3-Epi-betulinic acid 3- <i>O</i>- <i>β</i>- <i>D</i>-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma Open
3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) is a pentacyclic triterpene mainly distributed in food and medicinal plants, which exhibits various pharmacological properties. However, whether these functions are attributed to eBAG or …
View article: Secoisolariciresinol diglucoside Ameliorates Osteoarthritis via Nuclear factor-erythroid 2-related factor-2/ nuclear factor kappa B Pathway: In vitro and in vivo experiments
Secoisolariciresinol diglucoside Ameliorates Osteoarthritis via Nuclear factor-erythroid 2-related factor-2/ nuclear factor kappa B Pathway: In vitro and in vivo experiments Open
Osteoarthritis (OA) is an age-related joint disease in which inflammation and extracellular matrix (ECM) degradation play a crucial role in the destruction of articular cartilage. Secoisolariciresinol diglucoside (SDG), the main lignan in …
View article: Transoropharyngeal closed reduction for traumatic atlantoaxial dislocation: a novel technique for fast and precise reduction
Transoropharyngeal closed reduction for traumatic atlantoaxial dislocation: a novel technique for fast and precise reduction Open
Purpose The aim of this study is to introduce a new technique for the rapid and accurate reduction of traumatic atlantoaxial dislocation (TAAD) and to investigate its radiological and clinical outcomes. Methods The clinical outcomes of 18 …
View article: A comprehensive pan-cancer analysis unveiling the oncogenic effect of plant homeodomain finger protein 14 (PHF14) in human tumors
A comprehensive pan-cancer analysis unveiling the oncogenic effect of plant homeodomain finger protein 14 (PHF14) in human tumors Open
The plant homeodomain (PHD) finger refers to a protein motif that plays a key role in the recognition and translation of histone modification marks by promoting gene transcriptional activation and silencing. As an important member of the P…
View article: Development and validation of a prognostic nomogram for bone metastasis from lung cancer: A large population-based study
Development and validation of a prognostic nomogram for bone metastasis from lung cancer: A large population-based study Open
Background Bone is one of the most common metastatic sites of advanced lung cancer, and the median survival time is significantly shorter than that of patients without metastasis. This study aimed to identify prognostic factors associated …
View article: Periprosthetic Fractures and Acetabular Loosening after Surgical Treatment of Bilateral Femoral Neck Pathological Fractures Secondary to Hypocalcemic Seizure with Chronic Renal Failure：A Case Report and Review of the Literature
Periprosthetic Fractures and Acetabular Loosening after Surgical Treatment of Bilateral Femoral Neck Pathological Fractures Secondary to Hypocalcemic Seizure with Chronic Renal Failure：A Case Report and Review of the Literature Open
Background: Long-term hemodialysis treatment of chronic kidney disease (CKD) can lead to disorder of calcium and phosphorus regulation and abnormal parathyroid function.Most patients with renal failure often have secondary hyperparathyroid…
View article: Exosomal CTCF Confers Cisplatin Resistance in Osteosarcoma by Promoting Autophagy via the IGF2-AS/miR-579-3p/MSH6 Axis
Exosomal CTCF Confers Cisplatin Resistance in Osteosarcoma by Promoting Autophagy via the IGF2-AS/miR-579-3p/MSH6 Axis Open
Cancer-derived exosomes participate in carcinogenesis and progression of cancers, including metastasis and drug-resistance. Of note, CTCF has been suggested to induce drug resistance in various cancers. Herein, we aim to investigate the ro…
View article: A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures
A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures Open
The antioxidant gene signature models established in this study can be novel prognostic predictors for sarcoma.
View article: Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts
Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts Open
Disruption of extracellular matrix (ECM) homeostasis and subchondral bone remodeling play significant roles in osteoarthritis (OA) pathogenesis. Vindoline (Vin), an indole alkaloid extracted from the medicinal plant Catharanthus roseus , p…
View article: Analysis of Risk Factors for Non-union After Surgery for Limb Fractures: A Case-Control Study of 669 Subjects
Analysis of Risk Factors for Non-union After Surgery for Limb Fractures: A Case-Control Study of 669 Subjects Open
Objective: The purpose of this study was to analyze the risk factors for limb fracture non-union in order to improve non-union prevention and early detection. Methods: A total of 223 patients with non-union after surgery for limb fractures…
View article: An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors
An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors Open
There are three most important mismatch repair genes in the mismatch repair system, MSH6 is one of them and it plays an essential role in DNA mismatch repair. Several emerging cell- or animal-based studies have verified that MSH6 mutations…
View article: A Bone-Targeting Enoxacin Delivery System to Eradicate Staphylococcus Aureus-Related Implantation Infections and Bone Loss
A Bone-Targeting Enoxacin Delivery System to Eradicate Staphylococcus Aureus-Related Implantation Infections and Bone Loss Open
Post-operative infections in orthopaedic implants are severe complications that require urgent solutions. Although conventional antibiotics limit bacterial biofilm formation, they ignore the bone loss caused by osteoclast formation during …
View article: Bisphosphonate‐enoxacin inhibit osteoclast formation and function by abrogating RANKL‐induced JNK signalling pathways during osteoporosis treatment
Bisphosphonate‐enoxacin inhibit osteoclast formation and function by abrogating RANKL‐induced JNK signalling pathways during osteoporosis treatment Open
Osteoporosis is an age‐related disease characterized by low mineral density, compromised bone strength and increased risk of fragility fracture. Most agents for treating osteoporosis focus primarily on anti‐resorption by inhibiting osteocl…
View article: A large enhancement of ionic conductivity in SrCoO2.5 controlled by isostructural phase transition and negative linear compressibility
A large enhancement of ionic conductivity in SrCoO2.5 controlled by isostructural phase transition and negative linear compressibility Open
The exploration of next-generation materials and the underlying mechanisms for high ionic conductivity have been the mainstay of the study in the solid state ionic field, but with limited success. Here, we performed closely integrated in s…
View article: A Bone-Targeting Enoxacin Delivery System to Eradicate Staphylococcus Aureus-Related Implantation Infections and Bone Loss
A Bone-Targeting Enoxacin Delivery System to Eradicate Staphylococcus Aureus-Related Implantation Infections and Bone Loss Open
Post-operative infections in orthopaedic implants are severe complications that require urgent solutions. Although conventional antibiotics limit bacterial biofilms formation, they ignore the bone loss caused by osteoclast formation during…
View article: Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo
Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo Open
Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomi…
View article: Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study
Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study Open
Osteoporotic osteoarthritis (OP-OA) is a specific type of OA. In this study, we aimed to assess the subchondral plate and rod microstructural differences between OA and OP-OA patients by using an individual trabeculae segmentation (ITS) sy…
View article: LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway
LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway Open
The aim of this study was to investigate the roles and potential mechanisms of long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in the proliferation, migration, and invasion of Ewing's sarcoma cells. RT-qPCR was used to detec…
View article: The Role of Chemotherapy in the Survival Benefits of Patients Aged Older Than 40 Years With Osteosarcoma
The Role of Chemotherapy in the Survival Benefits of Patients Aged Older Than 40 Years With Osteosarcoma Open
Objectives: The value of chemotherapy in the survival benefits of patients aged > 40 years with osteosarcoma is controversial. We aimed to explore the impact of chemotherapy on the survival benefits of patients aged >40 years with osteosar…
View article: [Corrigendum] miR-30d inhibits cell biological progression of Ewing’s sarcoma by suppressing the MEK/ERK and PI3K/Akt pathways <i>in vitro</i>
[Corrigendum] miR-30d inhibits cell biological progression of Ewing’s sarcoma by suppressing the MEK/ERK and PI3K/Akt pathways <i>in vitro</i> Open
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1D on p. 4392, in the 0 h row the 'Scramble' and 'mimic' panels appeared to feature overlapping data. After having re‑e…