Xuran Wang
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View article: Screening and characterization of monoclonal antibodies with neutralizing activity against porcine transmissible gastroenteritis virus
Screening and characterization of monoclonal antibodies with neutralizing activity against porcine transmissible gastroenteritis virus Open
This study successfully generated TGEV-specific antibodies, providing critical support for fundamental research on TGEV research and the development of clinical diagnostic reagents.
View article: Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models
Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models Open
GABAergic interneurons play a critical role in maintaining neural circuit function, and their dysfunction is implicated in various neurodevelopmental and psychiatric disorders. Traditional approaches for differentiating human pluripotent s…
View article: Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain
Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain Open
Eating disorders (ED) and obsessive-compulsive disorder (OCD) exhibit significant clinical and genetic overlap, yet their shared molecular mechanisms remain unclear. We conducted a transcriptomic investigation of the dorsolateral prefronta…
View article: A scalable, high-throughput neural development platform identifies shared impact of ASD genes on cell fate and differentiation
A scalable, high-throughput neural development platform identifies shared impact of ASD genes on cell fate and differentiation Open
Background: Deleterious mutations in hundreds of genes confer high risk for neurodevelopmental disorders (NDDs), posing significant challenges for therapeutic development. Identifying convergent pathways shared across NDD genes could revea…
View article: Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways
Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways Open
Sex-differential gene expression is limited in prenatal human cortex tissue, although meta-analysis of large datasets allows for the identification of sex-DEGs, including autosomal genes that encode proteins involved in neural development.…
View article: Identification of pneumococcal serotypes with individual recognition of vaccine types by a highly multiplexed real-time PCR-based MeltArray approach
Identification of pneumococcal serotypes with individual recognition of vaccine types by a highly multiplexed real-time PCR-based MeltArray approach Open
We conclude that the PneumoSero assay can be implemented as a routine tool for pneumococcal serotyping in standard microbiology laboratories and even in clinical settings.
View article: The calculation model for average scores to analyze the variation of Wordle game
The calculation model for average scores to analyze the variation of Wordle game Open
Wordle is a very popular puzzle game offered by The New York Times. Every day, the puzzle editor provides a five-letter word as a riddle. we regard the associated percentages of (1, 2, 3, 4, 5, 6, X) as statistical probabilities and propos…
View article: MuSiC2: cell-type deconvolution for multi-condition bulk RNA-seq data
MuSiC2: cell-type deconvolution for multi-condition bulk RNA-seq data Open
Cell-type composition of intact bulk tissues can vary across samples. Deciphering cell-type composition and its changes during disease progression is an important step toward understanding disease pathogenesis. To infer cell-type compositi…
View article: Rapid detection of the irinotecan‐related <i>UGT1A1</i>*28 polymorphism by asymmetric PCR melting curve analysis using one fluorescent probe
Rapid detection of the irinotecan‐related <i>UGT1A1</i>*28 polymorphism by asymmetric PCR melting curve analysis using one fluorescent probe Open
Background Determination of UGT1A1 (TA) n polymorphism prior to irinotecan therapy is necessary to avoid severe adverse drug effects. Thus, accurate and reliable genotyping methods for (TA) n polymorphism are highly desired. Here, we prese…
View article: MuSiC2: cell type deconvolution for multi-condition bulk RNA-seq data
MuSiC2: cell type deconvolution for multi-condition bulk RNA-seq data Open
Cell type composition of intact bulk tissues can vary across samples. Deciphering cell type composition and its changes during disease progression is an important step towards understanding disease pathogenesis. To infer cell type composit…
View article: Constructing local cell-specific networks from single-cell data
Constructing local cell-specific networks from single-cell data Open
Significance Understanding gene regulatory networks is a topic of great interest because it can provide insights into cellular development, and identify factors that differ between normal and abnormal cells and phenotypes. Single-cell RNA …
View article: SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis
SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis Open
Single-cell CRISPR screens are a promising biotechnology for mapping regulatory elements to target genes at genome-wide scale. However, technical factors like sequencing depth impact not only expression measurement but also perturbation de…
View article: Wool-coiled bimetallic oxysulfide MoSrOS catalyst synthesis for catalytic reduction of toxic organic pollutants and heavy metal ions
Wool-coiled bimetallic oxysulfide MoSrOS catalyst synthesis for catalytic reduction of toxic organic pollutants and heavy metal ions Open
Wool-coiled MoSrOS bimetal oxysulfide catalysts were synthesized by a simple method. The catalysts were characterized by different instruments. The MoSrOS reduction activities were also investigated by the reduction of Cr(VI), Rhodamine-B …
View article: Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data
Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data Open
Allelic expression imbalance (AEI), quantified by the relative expression of two alleles of a gene in a diploid organism, can help explain phenotypic variations among individuals. Traditional methods detect AEI using bulk RNA sequencing (R…
View article: Constructing local Cell Sepcific Networks from Single Cell Data
Constructing local Cell Sepcific Networks from Single Cell Data Open
Single-cell RNA sequencing facilitates investigations of gene co-expression networks at the cellular level potentially yielding unique biological insights, but the estimation problem is challenging. We develop a non-parametric approach to …
View article: Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data
Detecting cell-type-specific allelic expression imbalance by integrative analysis of bulk and single-cell RNA sequencing data Open
Allelic expression imbalance (AEI), quantified by the relative expression of two alleles of a gene in a diploid organism, can help explain phenotypic variations among individuals. Traditional methods detect AEI using bulk RNA sequencing (R…
View article: Mendelian Randomization and Single Cell Deconvolution: Two Problems in Statistics Genetics
Mendelian Randomization and Single Cell Deconvolution: Two Problems in Statistics Genetics Open
Finding interpretable targets within the genome for diseases is a primary goal of biomedical research. This thesis focuses on developing statistical models and methods for analysis of high throughput genomic and transcriptomic sequencing d…
View article: Bulk Tissue Cell Type Deconvolution with Multi-Subject Single-Cell Expression Reference
Bulk Tissue Cell Type Deconvolution with Multi-Subject Single-Cell Expression Reference Open
We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-seq data in complex tissues. When applied to pancreatic islet a…
View article: A novel naphthalene carboxylic acid-based ionic liquid mixed disperser combined with ultrasonic-enhanced in-situ metathesis reaction for preconcentration of triclosan and methyltriclosan in milk and eggs
A novel naphthalene carboxylic acid-based ionic liquid mixed disperser combined with ultrasonic-enhanced in-situ metathesis reaction for preconcentration of triclosan and methyltriclosan in milk and eggs Open
A microextraction method was developed based on utilization of a novel ionic liquid (IL) [C4MIM][NCA] as disperser and conventional ILs as extractor (IL-IL-DLLME). This method was integrated with an in-situ metathesis reaction to achieve h…