Xuyuan Yin
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View article: VEGF as a Potential Factor in the Cognitive Impairment Assessment of Major Depressive Disorder: A Case-Control Study
VEGF as a Potential Factor in the Cognitive Impairment Assessment of Major Depressive Disorder: A Case-Control Study Open
Background Cognitive impairment in individuals with Major Depressive Disorder (MDD) may have an association with the levels of Vascular Endothelial Growth Factor (VEGF). Methods In this case-control study, we recruited 60 patients diagnose…
View article: Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia
Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia Open
BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6 (IL-6) contributes to the pathophysiology of psychiatric disorders. However, there was no study concerning the relationship between IL-6 concentrations …
View article: Characterization of the human induced pluripotent stem cell (iPSC) SZGJMSi004-A line from a 28-year-old Han male patient with depression
Characterization of the human induced pluripotent stem cell (iPSC) SZGJMSi004-A line from a 28-year-old Han male patient with depression Open
Peripheral blood mononuclear cells (PBMCs) from a 28-year-old male patient with unipolar depression were reprogrammed with reprogramming factors by electroporation. The pluripotency of transgene-free induced pluripotent stem cells (iPSCs) …
View article: Association of serum IL-6 with negative symptoms in stable early-onset schizophrenia
Association of serum IL-6 with negative symptoms in stable early-onset schizophrenia Open
Background: Accumulating evidence suggests that the inflammatory cytokine interleukin-6 (IL-6) contributes to the pathophysiology of psychiatric disorders. The purpose of the current study was to investigate the relationship between serum …
View article: The causal effect of schizophrenia on fractures and bone mineral density: a comprehensive two-sample Mendelian randomization study of European ancestry
The causal effect of schizophrenia on fractures and bone mineral density: a comprehensive two-sample Mendelian randomization study of European ancestry Open
View article: Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2
Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2 Open
Morinda officinalis oligosaccharides (MOs) are natural herbal extracts that have been shown to exert antidepressant effects. However, the mechanism of this effect remains unclear. Here, we explored the mechanism by which MOs improved exper…
View article: Association between stereopsis deficits and attention decline in patients with major depressive disorder
Association between stereopsis deficits and attention decline in patients with major depressive disorder Open
View article: MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells
MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells Open
Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in glioma. However, the underlying mechanism of chemotherapy-triggered EMT has not been fully un…
View article: Inhibition of Notch-1 pathway is involved in rottlerin-induced tumor suppressive function in nasopharyngeal carcinoma cells
Inhibition of Notch-1 pathway is involved in rottlerin-induced tumor suppressive function in nasopharyngeal carcinoma cells Open
Recent studies have revealed that rottlerin is a natural chemical drug to exert its anti-cancer activity. However, the molecular mechanisms of rottlerin-induced tumor suppressive function have not been fully elucidated. Notch signaling pat…
View article: Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells
Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells Open
Pancreatic cancer (PC) is one of the most aggressive human malignancies worldwide and is the fourth leading cause of cancer-related deaths. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Certain studies …
View article: Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells
Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells Open
Rottlerin, isolated from a medicinal plant Mallotus phillippinensis, has been demonstrated to inhibit cellular growth and induce cytoxicity in glioblastoma cell lines through inhibition of calmodulin-dependent protein kinase III. Emerging …
View article: Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells
Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells Open
Studies have investigated the tumor suppressive role of rottlerin in carcinogenesis. However, the molecular mechanisms of rottlerin-induced anti-tumor activity are largely unclear. Skp2 (S-phase kinase associated protein 2) has been valida…
View article: Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells.
Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells. Open
Rottlerin, a natural product isolated from Mallotus philippinensis, has been characterized as an effective chemoprevention agent in inhibiting tumor cell growth. Although multiple studies have revealed the role of rottlerin in tumorigenesi…
View article: Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells
Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells Open
Studies have demonstrated that curcumin exerts its tumor suppressor function in a variety of human cancers including glioma. However, the exact underlying molecular mechanisms remain obscure. Emerging evidence has revealed that Skp2 (S-pha…
View article: Arsenic Trioxide Inhibits Cell Growth and Invasion via Down-Regulation of Skp2 in Pancreatic Cancer Cells
Arsenic Trioxide Inhibits Cell Growth and Invasion via Down-Regulation of Skp2 in Pancreatic Cancer Cells Open
Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study, we explored the molecu…