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View article: Matrine nanoparticles improve functional constipation and associated depressive behavioral disorders by modulating the gut-brain axis
Matrine nanoparticles improve functional constipation and associated depressive behavioral disorders by modulating the gut-brain axis Open
Background: Functional constipation (FC) in the elderly is associated with depressive behavior. Matrine is a bioactive alkaloid with anti-inflammatory properties, promoting intestinal motility and gut barrier function. This study aimed to …
View article: PPP1R12A mutation leads to different genders of twinning: a case report and literature review
PPP1R12A mutation leads to different genders of twinning: a case report and literature review Open
This is the first instance of identical twins with a heterozygous mutation (c.1551-2A>G) in the PPP1R12A gene, associated with UBMS and DSD. The same variation resulted in identical twins exhibiting different genital phenotypes and choosin…
View article: Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota
Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota Open
Adequate sleep is of paramount importance for relieving stress and restoring mental vigor. However, the adverse physiological and pathological responses resulting from sleep insufficiency or sleep deprivation (SD) are becoming increasingly…
View article: [Construction of a prognostic nomogram combining PET/CT metabolic parameters and blood inflammatory markers for non-small cell lung cancer treated with first-line chemotherapy].
[Construction of a prognostic nomogram combining PET/CT metabolic parameters and blood inflammatory markers for non-small cell lung cancer treated with first-line chemotherapy]. Open
The baseline PET/CT metabolic parameters and blood inflammatory markers are associated with PFS and OS of patients with advanced NSCLC receiving first-line chemotherapy, and the constructed nomogram based on these parameters has a good per…
View article: Late Ordovician gastropods from the Zhaolaoyu Formation in the southwestern margin of the North China Platform
Late Ordovician gastropods from the Zhaolaoyu Formation in the southwestern margin of the North China Platform Open
The Ordos Basin is located in the western part of the North China Platform and is the second largest sedimentary basin in China; the basin has a huge thickness of the Early Palaeozoic marine deposits, especially the Ordovician ones. The Zh…
View article: Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China
Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China Open
Introduction: Essential Tremor (ET) is one of the most common movement disorders. Oral drugs play a crucial role in treating ET, with various available options such as propranolol, primidone and topiramate. However, the medication status a…
View article: Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China
Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China Open
Introduction: Essential Tremor (ET) is one of the most common movement disorders. Oral drugs play a crucial role in treating ET, with various available options such as propranolol, primidone and topiramate. However, the medication status a…
View article: Supplementary Material for: Preoperative H. pylori eradication therapy facilitates precise delineation in early gastric cancer with current H. pylori infection
Supplementary Material for: Preoperative H. pylori eradication therapy facilitates precise delineation in early gastric cancer with current H. pylori infection Open
[Introduction] Early gastric cancer with current Helicobacter pylori infection (HpC-EGC) is common but still unclear whether H. pylori eradication therapy (Hp-ET) or endoscopic submucosal dissection (ESD) should be performed first. We eval…
View article: Supplementary Material for: Preoperative H. pylori eradication therapy facilitates precise delineation in early gastric cancer with current H. pylori infection
Supplementary Material for: Preoperative H. pylori eradication therapy facilitates precise delineation in early gastric cancer with current H. pylori infection Open
[Introduction] Early gastric cancer with current Helicobacter pylori infection (HpC-EGC) is common but still unclear whether H. pylori eradication therapy (Hp-ET) or endoscopic submucosal dissection (ESD) should be performed first. We eval…
View article: Supplementary Material for: Right heart structure and function after electrical cardioversion for atrial fibrillation
Supplementary Material for: Right heart structure and function after electrical cardioversion for atrial fibrillation Open
Introduction: Atrial fibrillation (AF) adversely impacts right ventricular (RV) and right atrial (RA) structure and function. There is limited data on these changes after electrical cardioversion (ECV) and the relative contribution of hear…
View article: Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China
Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China Open
Introduction: Essential Tremor (ET) is one of the most common movement disorders. Oral drugs play a crucial role in treating ET, with various available options such as propranolol, primidone and topiramate. However, the medication status a…
View article: Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China
Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China Open
Introduction: Essential Tremor (ET) is one of the most common movement disorders. Oral drugs play a crucial role in treating ET, with various available options such as propranolol, primidone and topiramate. However, the medication status a…
View article: Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China
Supplementary Material for: Medication status and related factors in essential tremor patients: a cross-sectional study in China Open
Introduction: Essential Tremor (ET) is one of the most common movement disorders. Oral drugs play a crucial role in treating ET, with various available options such as propranolol, primidone and topiramate. However, the medication status a…
View article: Bevacizumab is an Efficient Therapeutic Approach with Low Side Effects in Patient-Derived Xenografts of Adenoid Cystic Carcinoma of the Lacrimal Gland
Bevacizumab is an Efficient Therapeutic Approach with Low Side Effects in Patient-Derived Xenografts of Adenoid Cystic Carcinoma of the Lacrimal Gland Open
Jingxue Zhang,1,2,* Xuejing Yan,1,* Rui Liu,3 Shen Wu,1,2 Qian Liu,1,2 Jing Li,3 Jianmin Ma3 1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Vis…
View article: Supplementary Material for: Clinical Significance and Properties of IFN-γ<sup>+</sup>IL-17<sup>+</sup> Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection
Supplementary Material for: Clinical Significance and Properties of IFN-γ<sup>+</sup>IL-17<sup>+</sup> Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection Open
Introduction: Our previous study demonstrated that intrahepatic Th17 cells exacerbated the progression of chronic hepatitis B virus (HBV) infection. Meanwhile, we found a small group of IFN-γ and IL-17 double-positive Th17 cells (IFN-γ+IL-…
View article: Primary Malignant Melanoma of Vagina: A Clinicopathologic Analysis of 6 Cases
Primary Malignant Melanoma of Vagina: A Clinicopathologic Analysis of 6 Cases Open
Introduction/Objective Primary malignant melanoma of vagina (PMMV) has a very high rate of recurrence and poor long-term survival. Less than 250 cases are reported in English literature to date, optimal treatments, risk factors, and progno…
View article: Risk Factors and Neurologic Outcomes in Patients with Traumatic Brain Injury and Coagulopathy Within 72 h After Surgery
Risk Factors and Neurologic Outcomes in Patients with Traumatic Brain Injury and Coagulopathy Within 72 h After Surgery Open
Tao Chang,1,* Xigang Yan,2,* Chao Zhao,3,* Yufu Zhang,4 Bao Wang,4 Li Gao4 1Department of Emergency, The Second Affiliated Hospital of Air Force Medical University, Xi’an, 710038, Shaanxi Province, People’s Republic of China; 2Department o…
View article: Reactive Langerhans Cell Proliferation Mimicking Langerhans Cell Histiocytosis in Association with Sézary Syndrome: A Case Report and Literature Review
Reactive Langerhans Cell Proliferation Mimicking Langerhans Cell Histiocytosis in Association with Sézary Syndrome: A Case Report and Literature Review Open
Jinjing Zhang,1 Shiyu Ma,1 Jinxiang Yu,1 Song Zheng,2 Yuan Miao,3 Pingping Wang,1 Xiaojing Yan1 1Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China; 2…
View article: Surgical Resection of Pancreatic Hepatoid Carcinoma Followed by Combined Transarterial Chemoembolization and Immunotherapy: A Case Report
Surgical Resection of Pancreatic Hepatoid Carcinoma Followed by Combined Transarterial Chemoembolization and Immunotherapy: A Case Report Open
Jintong He,1 Qinying Zhao,2 Qiang Liu,1 Fei Li,1 Long He,1 Mengyi Liu,1 Xiong Yan1 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of E…
View article: Promising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report
Promising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report Open
Pan Hu,1,* Yu Ben,1,* Juan Liu,1 Weicheng Zheng,1 Xiyue Yan,1 Yaping Zhang,2 Wenyu Shi1,2 1Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People&rsquo;s Republic of China; 2Department of He…
View article: Cost-Effectiveness of Ribociclib for Hormone Receptor-Positive HER2-Negative Advanced Breast Cancer
Cost-Effectiveness of Ribociclib for Hormone Receptor-Positive HER2-Negative Advanced Breast Cancer Open
Jiangping Yang,1,* Jiaqi Han,1,* Maolang Tian,1 Kun Tian,2 Wenjun Liao,1 Xi Yan3,4 1Department of Head and Neck Oncology and Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichu…
View article: First Report Cfr and OptrA Co-harboring Linezolid-Resistant Enterococcus faecalis in China
First Report Cfr and OptrA Co-harboring Linezolid-Resistant Enterococcus faecalis in China Open
Qingqing Chen,1,2 Dandan Yin,1,3 Pei Li,1,3 Yan Guo,1,3 Desong Ming,2 Yuling Lin,2 Xiaoli Yan,2 Zhishan Zhang,2 Fupin Hu1,3 1Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People&rsquo;s Republic of China; 2The…
View article: Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury
Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury Open
Yulu Zhang,1,* Songyu Liu,1,* Jinyan Wan,1,* Qiyue Yang,2 Yan Xiang,1 Li Ni,1 Yu Long,1 Mingquan Cui,1 Zhimin Ci,1 Donglei Tang,1 Nan Li1 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People’s Re…
View article: Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects
Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects Open
Hong Zhou,1,* Pan Hu,1,* Xiyue Yan,1 Yaping Zhang,2 Wenyu Shi1,2 1Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic of China; 2Department of Hematology, Affiliated Hospital …
View article: [Anterior subcutaneous internal fixation combined with posterior percutaneous iliosacral screw for treatment of unstable pelvic fractures].
[Anterior subcutaneous internal fixation combined with posterior percutaneous iliosacral screw for treatment of unstable pelvic fractures]. Open
Minimally invasive pelvic stabilization by using anterior subcutaneous INFIX and posterior percutaneous iliosacral screw for treatment of unstable pelvic fractures, can achieve good fracture reduction and definitive stabilization with mini…
View article: Simultaneous Intramuscular And Intranasal Administration Of Chitosan Nanoparticles–Adjuvanted Chlamydia Vaccine Elicits Elevated Protective Responses In The Lung
Simultaneous Intramuscular And Intranasal Administration Of Chitosan Nanoparticles–Adjuvanted Chlamydia Vaccine Elicits Elevated Protective Responses In The Lung Open
Yumeng Li,1 Chuan Wang,1 Zhenjie Sun,1 Jian Xiao,1 Xiaoliang Yan,1 Yuqing Chen,1 Jian Yu,2 Yimou Wu1 1Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institution of Pathogenic Biology, Hengyang Medical College…
View article: Prevalence and identification of type 1 diabetes in Chinese adults with newly diagnosed diabetes
Prevalence and identification of type 1 diabetes in Chinese adults with newly diagnosed diabetes Open
Xiaohan Tang,1–3 Xiang Yan,1–3 Houde Zhou,1,3–4 Xilin Yang,5 Xiaohong Niu,6 Jing Liu,7 Qiuhe Ji,8 Linong Ji,9 Xia Li,1–3 Zhiguang Zhou1–3 On behalf of the National Clinical Research Center for Metabolic Diseases Study Group1Department of M…
View article: Pulmonary Inflammatory Myofibroblastic Tumor: Surgical Resection and Long-Term Surveillance
Pulmonary Inflammatory Myofibroblastic Tumor: Surgical Resection and Long-Term Surveillance Open
Objective: Inflammatory myofibroblastic tumor is a very rare mesenchymal tumor, we share our experience of surgical treatment for inflammatory myofibroblastic tumor. Materials and methods:From January 2005 to January 2015, 32 patients were…
View article: CEACAM6 is associated with osteosarcoma metastasis and facilitates epithelial&ndash;mesenchymal transition in osteosarcoma cells
CEACAM6 is associated with osteosarcoma metastasis and facilitates epithelial–mesenchymal transition in osteosarcoma cells Open
Zeyu Wang,1 Chong Luo,1 Huidan Wang,2 Xia Yan,2 Wei Liu,1 Zengdong Meng1 1Department of Orthopaedics, The First People’s Hospital of Yunnan Province, Dali 650000, Yunnan, People’s Republic of China; 2Medical Faculty, Kunming Un…