Angela Yee‐Moon Wang
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View article: Cardiac Impact of Dapagliflozin in Advanced Chronic Kidney Disease: Rationale and Design of the Renal Lifecycle Trial Cardiac Imaging Sub-studies
Cardiac Impact of Dapagliflozin in Advanced Chronic Kidney Disease: Rationale and Design of the Renal Lifecycle Trial Cardiac Imaging Sub-studies Open
Background Patients with chronic kidney disease (CKD) are frequently hospitalized for heart failure. Sodium glucose co-transporter 2 (SGLT2)-inhibitors improve cardiorenal outcomes in CKD and heart failure, at least in estimated glomerular…
View article: Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts
Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts Open
Background Prior prediction equations for heart failure (HF) omitted cardiac biomarkers and used select populations. We assessed the added value of NT‐proBNP (NT‐terminal pro‐brain natriuretic peptide) and hsTnT (high‐sensitivity troponin …
View article: Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis Open
Background Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. Methods This was an individual participant data meta-analysis including 54 international cohorts contribut…
View article: Project Sleep: A Digital Sleep Single Session Intervention to Improve Sleep Problems in Young People
Project Sleep: A Digital Sleep Single Session Intervention to Improve Sleep Problems in Young People Open
This project investigates initial feasibilty, acceptability, and proximal outcomes for Project Sleep, a single-session intervention designed to mitigate sleep problems among young people.
View article: Justice in healthcare resource allocation: Prioritizing the worse-off
Justice in healthcare resource allocation: Prioritizing the worse-off Open
During the COVID-19 pandemic, severe shortages of healthcare resources like ventilators and vaccines laid deep-seated moral dilemmas in distribution. Utilitarianism, which seeks to maximize overall societal welfare, often led to allocating…
View article: Cultural influences on convenience spending: A behavioral economics comparison of American and Taiwanese consumers
Cultural influences on convenience spending: A behavioral economics comparison of American and Taiwanese consumers Open
Why do some cultures gladly pay more for convenience, while others opt to invest time and energy to save money? This study examines the influence of cultural values on daily financial choices, with a specific focus on food delivery consump…
View article: Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection
Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection Open
The gut microbiome's pivotal role in health and disease is well established. SARS-CoV-2 infection often causes gastrointestinal symptoms and is associated with changes of the microbiome in both human and animal studies. While hamsters serv…
View article: Design of a Personalized Adaptive Human-Machine Interaction System for a Single Pilot
Design of a Personalized Adaptive Human-Machine Interaction System for a Single Pilot Open
With the rapid development of the aerospace industry, there is a trend towards transitioning from two-person to single-pilot crewing. However, to ensure safety during flight operations, it is crucial to adhere to the principle that the wor…
View article: US Attorney Demands CHEST Assurance of “Viewpoint Diversity”
US Attorney Demands CHEST Assurance of “Viewpoint Diversity” Open
No abstract available. Article truncated after 150 words. NBC News is reporting on a Facebook posting of a letter from the acting U.S. attorney for the District of Columbia to the editor of a CHEST. The letter implies that the medical jour…
View article: Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier Open
Barriers of the central nervous system (CNS), such as the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), regulate the two-way exchange of material between the blood and CNS. These barriers pose a considerable chal…
View article: Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease
Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease Open
Background Several clinical trials have shown beneficial effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) w…
View article: Patient pathway analysis of rifampicin-resistant TB diagnostic and treatment delays
Patient pathway analysis of rifampicin-resistant TB diagnostic and treatment delays Open
BACKGROUNDBarriers to the diagnosis and treatment of rifampicin-resistant TB (RR-TB) have not been fully elucidated. This study aimed to map the diagnostic and treatment delays among patients with RR-TB in China and investigate related fac…
View article: Homemade formulas for nutrition support in chronic kidney disease: A narrative review of the opportunity for education, research, and innovation
Homemade formulas for nutrition support in chronic kidney disease: A narrative review of the opportunity for education, research, and innovation Open
Protein‐energy wasting is common in people with chronic kidney disease (CKD), especially in those undergoing kidney replacement therapy. Oral nutrition supplements and enteral nutrition are strategies that have been shown to improve nutrit…
View article: Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes, smoking, and lung cancer
Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes, smoking, and lung cancer Open
Emerging evidence highlights the role of thyroid hormones in cancer, although findings are controversial. Research on thyroid-related traits in lung carcinogenesis is limited. Using UK Biobank data, we performed bidirectional Mendelian ran…
View article: Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection
Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection Open
The gut microbiome’s pi votal role in health and disease is well-established. SARS-CoV-2 infection often causes gastrointestinal symptoms and is associated with changes of the microbiome in both human and animal studies. While hamsters ser…
View article: Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report
Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report Open
Background Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically import…
View article: Kernel Looping: Eliminating Synchronization Boundaries for Peak Inference Performance
Kernel Looping: Eliminating Synchronization Boundaries for Peak Inference Performance Open
Token generation speed is critical to power the next wave of AI inference applications. GPUs significantly underperform during token generation due to synchronization overheads at kernel boundaries, utilizing only 21% of their peak memory …
View article: Lymphotoxin-driven meningeal BAFF/CXCL13 imbalance and grey matter injury
Lymphotoxin-driven meningeal BAFF/CXCL13 imbalance and grey matter injury Open
In people living with multiple sclerosis (pwMS), brain leptomeningeal immune aggregates associate with subpial cortical pathology and disease progression, but the mechanism leading to this pathology is unknown. Moreover, biomarkers for bra…
View article: Assessing fecal metaproteomics workflow and small protein recovery using DDA and DIA PASEF mass spectrometry
Assessing fecal metaproteomics workflow and small protein recovery using DDA and DIA PASEF mass spectrometry Open
Aim: This study aims to evaluate the impact of experimental workflow on fecal metaproteomic observations, including the recovery of small and antimicrobial proteins often overlooked in metaproteomic studies. The overarching goal is to prov…