Yanru Wang
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View article: Breastfeeding challenges experienced by postpartum nurses after maternity leave: a qualitative systematic review
Breastfeeding challenges experienced by postpartum nurses after maternity leave: a qualitative systematic review Open
In this review, the breastfeeding practice of postpartum returning nurses is complex, which affects the breastfeeding experience together with their professional identity. Breastfeeding attitude, breastfeeding support, and breastfeeding co…
View article: A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma
A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma Open
Background The Hedgehog signaling pathway is involved in the carcinogenesis and development of hepatocellular carcinoma(HCC); however, few studies on the prognostic model of the Hedgehog signaling pathway have been found. Methods First, we…
View article: Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of <scp>STXBP1</scp> ‐Related Epileptic Encephalopathy
Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of <span>STXBP1</span> ‐Related Epileptic Encephalopathy Open
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1 , are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement…
View article: Gender and age variations in neuropsychiatric adverse events of cetirizine and levocetirizine: a disproportionality analysis of ICSRs from FAERS and EudraVigilance data
Gender and age variations in neuropsychiatric adverse events of cetirizine and levocetirizine: a disproportionality analysis of ICSRs from FAERS and EudraVigilance data Open
Background This study analyzed neuropsychiatric adverse drug events (ADEs) associated with cetirizine and levocetirizine using data from the FDA Adverse Event Reporting System (FAERS) and EudraVigilance databases to inform safer clinical u…
View article: SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting
SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting Open
Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8 + T cell populations are reduced, the level of which has…
View article: Density functional theory study on the formation mechanism and electronic properties of two-dimensional electron gas in LaInO3/BaSnO3 heterostructures with ferroelectric engineering
Density functional theory study on the formation mechanism and electronic properties of two-dimensional electron gas in LaInO3/BaSnO3 heterostructures with ferroelectric engineering Open
Compared to the well-studied LaAlO3/SrTiO3 heterostructure (HS), the regulation mechanism of ferroelectric on the interfacial properties of LaInO3/BaSnO3 HS remains relatively unexplored. Here, we investigate the interfacial properties of …
View article: Fibrous-layer resident Angptl7+ periosteal stem cells sense injury inflammation to orchestrate fracture repair
Fibrous-layer resident Angptl7+ periosteal stem cells sense injury inflammation to orchestrate fracture repair Open
Periosteum contains abundant Ctsk-lineage skeletal stem cells (P-SSCs) that are key drivers of intramembranous ossification during bone development and maintenance. However, P-SSCs regenerate fractured bones by mediating endochondral ossif…
View article: Cnidium monnieri Polysaccharides Exhibit Inhibitory Effect on Airborne Transmission of Influenza A Virus
Cnidium monnieri Polysaccharides Exhibit Inhibitory Effect on Airborne Transmission of Influenza A Virus Open
Influenza A virus (IAV) continues to present a threat to public health, highlighting the need for safe and multi-target antivirals. In this study, anti-influenza activity, airborne transmission blocking capacity, and immunomodulatory effec…
View article: A TGF-β1/LEF1/β-catenin/JLP network motif regulates autophagy and tubule injury in renal fibrosis
A TGF-β1/LEF1/β-catenin/JLP network motif regulates autophagy and tubule injury in renal fibrosis Open
Sustained injury to renal tubular epithelial cells (TECs), driven by excessive autophagy, is a critical mechanism underlying kidney fibrosis. Our previous work identified JLP-a TEC-expressed scaffolding protein-as an endogenous anti-fibrot…
View article: VvmiR408 positively modulates seedlessness formation by cleaving VvAGL61 in grape berries
VvmiR408 positively modulates seedlessness formation by cleaving VvAGL61 in grape berries Open
Grape seedlessness, a pivotal agronomic trait, is governed by intricate molecular mechanisms that remain partially elucidated. In this study, we identified VvmiR408 as a key regulator targeting VvAGL61 (a class D MADS-box gene) through RLM…
View article: Case Report: An extremely rare case of epithelioid STUMPs
Case Report: An extremely rare case of epithelioid STUMPs Open
Introduction Uterine leiomyomas are the most common benign tumors of the female reproductive system. Epithelioid STUMP is a special and relatively rare type of uterine leiomyoma that may exhibit malignant potential as smooth muscle tumors …
View article: Human Dental Pulp Stem Cells Attenuate Neuroinflammation and Neurological Deficit in a Murine Model of Multiple Sclerosis
Human Dental Pulp Stem Cells Attenuate Neuroinflammation and Neurological Deficit in a Murine Model of Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system mediated by autoimmune demyelination. While treatments targeting the peripheral immune system have been effective in reducing relapse risks for MS pati…
View article: Investigation of the biomechanical changes at the iris-lens interface after vitrectomy with silicone oil tamponade: Insights from ultrasound biomicroscopy
Investigation of the biomechanical changes at the iris-lens interface after vitrectomy with silicone oil tamponade: Insights from ultrasound biomicroscopy Open
This prospective cohort study investigated anterior segment biomechanical alterations and lens stability using ultrasound biomicroscopy (UBM) in 60 eyes (58 patients) undergoing pars plana vitrectomy (PPV) with silicone oil (SO) tamponade …
View article: EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2
EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2 Open
Enhancer of Zeste Homolog 2 (EZH2) is the enzymatic subunit of the Polycomb Repressive Complex 2 (PRC2). It catalyzes H3K27 methylation for epigenetic silencing of tumor suppressors and critically drives prostate cancer (PCa) progression. …
View article: Investigating the mechanisms of ageing and neuroinflammation in age-related hearing loss: A proteomic analysis
Investigating the mechanisms of ageing and neuroinflammation in age-related hearing loss: A proteomic analysis Open
In conclusion, we predict that aging may hinder the microtubule transport pathway, affect the CAMS and acidic glycoprotein pathways, influence the differential expression of proteins, thereby leading to the occurrence and development of AR…
View article: AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis Open
RNA binding proteins could regulate transcription through modulating RNA polymerase II involved transcriptional condensates with the aid of nascent RNA. However, whether this mechanism also contributes to tumorigenesis is still unknown. He…
View article: DNA actively regulates the “safety-belt” dynamics of condensin during loop extrusion
DNA actively regulates the “safety-belt” dynamics of condensin during loop extrusion Open
Condensin plays an essential role in genome folding through its active DNA loop extrusion activity. Condensin contains a binding interface between its Ycg1 HEAT-repeat subunit and the Brn1 kleisin, together forming a "safety-belt" DNA-bind…
View article: MRI-to-PET synthesis via deep learning for amyloid-β quantification in Alzheimer’s disease
MRI-to-PET synthesis via deep learning for amyloid-β quantification in Alzheimer’s disease Open
Objectives Amyloid-β (Aβ) PET is crucial for diagnosing and monitoring Alzheimer’s disease (AD), but its high cost and radiation exposure limit its use. Deep learning techniques make it possible to generate PET from structured MRI data. In…
View article: Integrated Single-Cell and Bulk Transcriptomics Unveils Immune Profiles in Chick Erythroid Cells upon Avian Pathogenic Escherichia coli Infection
Integrated Single-Cell and Bulk Transcriptomics Unveils Immune Profiles in Chick Erythroid Cells upon Avian Pathogenic Escherichia coli Infection Open
Nucleated erythroid cells (NECs) have emerged as active participants in immune responses in addition to their canonical oxygen transport function. The subpopulations and immune heterogeneity of chick erythroid cells (ch-ECs) upon infection…
View article: CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions
CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions Open
Cell fate decisions are orchestrated by intricate gene regulatory networks (GRNs), which govern gene expression with precise spatiotemporal control. However, accurately capturing context‐specific nature of gene regulation remains challengi…
View article: Effect of electroacupuncture on metabolic level and quality of life in patients with obese polycystic ovary syndrome: a randomized controlled trial
Effect of electroacupuncture on metabolic level and quality of life in patients with obese polycystic ovary syndrome: a randomized controlled trial Open
Objective This study aims to investigate the effects of electroacupuncture (EA) intervention on patients with obese polycystic ovary syndrome (PCOS), with specific analysis focusing on the following dimensions: 1) whether EA can reduce pat…
View article: Practical application and evaluation of an integrated training pathway for mental health literacy and clinical communication skills for undergraduate dental students based on simulation-based training
Practical application and evaluation of an integrated training pathway for mental health literacy and clinical communication skills for undergraduate dental students based on simulation-based training Open
Objective To construct and evaluate a comprehensive training pathway based on simulated operation training to improve the mental health literacy and clinical communication skills of junior dental undergraduate students. Methods A quasi-ran…
View article: RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses
RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses Open
Our findings reveal that RIPK3 can mediate MFN2 phosphorylation to promote ER-mitochondria interaction and mitochondrial Ca2+ overload, leading to the induction of cardiac necroptosis.
View article: Photo-cross-linking-assisted deorphanization deciphers GPR50–L-LEN pairing in metabolism
Photo-cross-linking-assisted deorphanization deciphers GPR50–L-LEN pairing in metabolism Open
G-protein-coupled receptors (GPCRs) are transmembrane proteins that transduce extracellular stimuli into intracellular events. While central to physiology and drug discovery, approximately 100 GPCRs remain orphan, limiting insights into th…
View article: Microbial Cell Factories for Phenylethanoid Glycosides: A Review on Engineering Strategies and Perspectives
Microbial Cell Factories for Phenylethanoid Glycosides: A Review on Engineering Strategies and Perspectives Open
Due to the neuroprotective and antioxidant properties, phenylethanoid glycosides (PhGs) are valuable plant-derived compounds. Traditional extraction methods are constrained by low yields and limited resources, prompting the integration of …
View article: The role and mechanism of post-translational modifications (PTMs) in immune-related eye diseases
The role and mechanism of post-translational modifications (PTMs) in immune-related eye diseases Open
Post-translational modifications (PTMs) encompass the spectrum of chemical covalent alterations that proteins undergo after being synthesized from mRNA. These modifications typically involve the covalent bonding of chemical groups or small…