Dora Y. Ho
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View article: Impending arterial thrombosis in pediatric liver transplantation: Initial experience with alteplase - A case report
Impending arterial thrombosis in pediatric liver transplantation: Initial experience with alteplase - A case report Open
Thrombolytic therapy with alteplase is a possible and effective alternative in managing eHAT, particularly where conventional options are not indicated or limited.
View article: The Evolving Landscape of Viral Infections in Immunocompromised Hosts
The Evolving Landscape of Viral Infections in Immunocompromised Hosts Open
There has arguably never been a more dynamic and challenging time to be a clinician or researcher in the field of transplant and immunocompromised infectious diseases [...]
View article: Treating Adenovirus Infection in Transplant Populations: Therapeutic Options Beyond Cidofovir?
Treating Adenovirus Infection in Transplant Populations: Therapeutic Options Beyond Cidofovir? Open
Adenovirus (AdV) infections can lead to significant morbidity and increased mortality in immunocompromised populations such as hematopoietic stem cell and solid organ transplant recipients. This review evaluates currently available and eme…
View article: Managing infectious challenges in the age of molecular‐targeted therapies for adult hematological malignancies
Managing infectious challenges in the age of molecular‐targeted therapies for adult hematological malignancies Open
Over the last decade, the therapeutic landscape for hematological malignancies (HMs) has witnessed a remarkable surge in the development of novel biological and small‐molecule‐targeted immunomodulatory agents. These therapies have drastica…
View article: Dynamics and prognostic value of plasma cell-free DNA PCR in patients with invasive aspergillosis and mucormycosis
Dynamics and prognostic value of plasma cell-free DNA PCR in patients with invasive aspergillosis and mucormycosis Open
Aspergillus species and Mucorales agents are the primary etiologies of invasive fungal disease (IFD). Biomarkers that predict outcomes are needed to improve care. Patients diagnosed with invasive aspergillosis and mucormycosis using plasma…
View article: Neuroinvasive <i>Francisella tularensis</i> Infection: Report of 2 Cases and Review of the Literature
Neuroinvasive <i>Francisella tularensis</i> Infection: Report of 2 Cases and Review of the Literature Open
Background Neuroinvasive infection with Francisella tularensis, the causative agent of tularemia, is rare. Establishing clinical suspicion is challenging if risk factors or clinical features classically associated with tularemia are absent…
View article: Case Report: Relapsing Leptospirosis in an Immunocompromised Host
Case Report: Relapsing Leptospirosis in an Immunocompromised Host Open
Leptospirosis is typically a self-limited febrile illness; when it occurs, meningitis usually develops early in the course. Here, we describe a patient who had engaged in freshwater activities in Kauai that was immunocompromised due to a h…
View article: Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients
Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients Open
Herpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infectio…
View article: 14. Monkeypox viral detection from different body sites. Northern California, June–July 2022
14. Monkeypox viral detection from different body sites. Northern California, June–July 2022 Open
Background Unlike prior outbreaks of monkeypox, the 2022 outbreak is unique because lesions have been predominantly noted in the anogenital area, especially among persons identifying as gay, bisexual, or other men who have sex with men. Th…
View article: Invasive mold infection of the gastrointestinal tract: A case series of 22 immunocompromised patients from a single academic center
Invasive mold infection of the gastrointestinal tract: A case series of 22 immunocompromised patients from a single academic center Open
Invasive mold infection (IMI) of the gastrointestinal (GI) tract is a rare complication in immunocompromised patients that carries a high mortality rate. It is most often described in the setting of disseminated disease. Early diagnosis an…
View article: Skull base osteomyelitis in patients with head and neck cancer: Diagnosis, management, and outcomes in a case series of 23 patients
Skull base osteomyelitis in patients with head and neck cancer: Diagnosis, management, and outcomes in a case series of 23 patients Open
Background Skull base osteomyelitis (SBO) is an infection of the central cranial bones, most commonly resulting from contiguous spread of infection from adjacent head and neck structures. SBO is a well‐recognized complication of treatment …
View article: Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis
Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis Open
Histoplasmosis-associated hemophagocytic lymphohistiocytosis is a rate but lethal disease in immunocompromised hosts. Unusual clinical presentations make diagnosing invasive fungal infection even more challenging. Here we present a case of…
View article: Clinical Accuracy and Impact of Plasma Cell-Free DNA Fungal Polymerase Chain Reaction Panel for Noninvasive Diagnosis of Fungal Infection
Clinical Accuracy and Impact of Plasma Cell-Free DNA Fungal Polymerase Chain Reaction Panel for Noninvasive Diagnosis of Fungal Infection Open
This is the accepted manuscript version of the work published in its final form as Senchyna, Fiona; Hogan, Catherine A; Murugesan, Kanagavel; Moreno, Angel; Ho, Dora Y; Subramanian, Aruna; Schwenk, Hayden T; Budvytiene, Indre; Costa, Helio…
View article: Appropriate Vancomycin Use and Incidence of Vancomycin-Resistant Enterococci in Liver Transplant Recipients
Appropriate Vancomycin Use and Incidence of Vancomycin-Resistant Enterococci in Liver Transplant Recipients Open
Liver transplant recipients (LTRs) are at risk for vancomycin-resistant Enterococcus (VRE) infections which can lead to significant morbidity or mortality. Antibiotic exposure, including vancomycin, is associated with greater risk of VRE i…
View article: Influence of immunosuppression on seroconversion against SARS‐CoV‐2 in two kidney transplant recipients
Influence of immunosuppression on seroconversion against SARS‐CoV‐2 in two kidney transplant recipients Open
Solid organ transplant recipients are at risk for infectious complications due to chronic immunosuppression. The outbreak of coronavirus disease 2019 (COVID‐19) in the United States has raised growing concerns for the transplant patient po…
View article: Missed diagnosis and misdiagnosis of infectious diseases in hematopoietic cell transplant recipients: an autopsy study
Missed diagnosis and misdiagnosis of infectious diseases in hematopoietic cell transplant recipients: an autopsy study Open
Key Points Infectious diseases are the second most common cause of death in HCT recipients, but some are first identified only by autopsy. Autopsy is underutilized and should be performed regularly to help improve infection-related morbidi…
View article: 1735. Epidemiology of Invasive Fungal Infections During Induction Chemotherapy in Adults With Newly Diagnosed Acute Myeloid Leukemia Without Antifungal Prophylaxis: A Retrospective Cohort Study
1735. Epidemiology of Invasive Fungal Infections During Induction Chemotherapy in Adults With Newly Diagnosed Acute Myeloid Leukemia Without Antifungal Prophylaxis: A Retrospective Cohort Study Open
Background While invasive fungal infections (IFIs) are common in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy, little current data exist on the epidemiology of IFIs in this patient population given widesprea…
View article: A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation
A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation Open
Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West…
View article: Respiratory Viral Infections in Transplant Recipients
Respiratory Viral Infections in Transplant Recipients Open
Respiratory viral infections (RVIs) are common among the general population; however, these often mild viral illnesses can lead to serious morbidity and mortality among recipients of hematopoietic stem cell and solid organ transplantation.…
View article: 1573. Discrepancies Between Premortem and Postmortem Diagnoses of Infectious Diseases Found on Autopsy in Hematopoietic Cell Transplantation Recipients at a High-Volume Academic Transplant Center
1573. Discrepancies Between Premortem and Postmortem Diagnoses of Infectious Diseases Found on Autopsy in Hematopoietic Cell Transplantation Recipients at a High-Volume Academic Transplant Center Open
BACKGROUND: Hematopoietic cell transplantation (HCT) is a potentially curative treatment option for patients with hematologic malignancies and other diseases but carries a significant risk of infection-related morbidity and mortality. Many…
View article: 1541. Infectious Complications in Adult Patients with Hemophagocytic Lymphohistiocytosis: A Single-Center Experience
1541. Infectious Complications in Adult Patients with Hemophagocytic Lymphohistiocytosis: A Single-Center Experience Open
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare hematologic disorder which is characterized by excessive immune activation. In adults, it is typically secondary to an underlying process such as autoimmune disease, infection,…
View article: Fatal <i>Emmonsia</i> sp. Infection and Fungemia after Orthotopic Liver Transplantation
Fatal <i>Emmonsia</i> sp. Infection and Fungemia after Orthotopic Liver Transplantation Open
We report a fatal case of disseminated Emmonsia sp. infection in a 55-year-old man who received an orthotopic liver transplant. The patient had pneumonia and fungemia, and multisystem organ failure developed. As human habitats and the numb…
View article: Donor-Derived Coccidioides immitis Endocarditis and Disseminated Infection in the Setting of Solid Organ Transplantation
Donor-Derived Coccidioides immitis Endocarditis and Disseminated Infection in the Setting of Solid Organ Transplantation Open
Background. Endocarditis is a rare manifestation of infection with Coccidioides. This is the first reported case of donor-derived Coccidioides endocarditis obtained from a heart transplant. Methods. We present a unique case of donor-derive…