Yuan Zhang
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View article: A Multicenter, Randomized, Controlled Clinical Trial on the Efficacy and Safety of Eucalyptol, Limonene, and Pinene Enteric Capsules in the Treatment of Chronic Rhinosinusitis With Nasal Polyps Postoperatively
A Multicenter, Randomized, Controlled Clinical Trial on the Efficacy and Safety of Eucalyptol, Limonene, and Pinene Enteric Capsules in the Treatment of Chronic Rhinosinusitis With Nasal Polyps Postoperatively Open
Background Eucalyptol, limonene, and pinene enteric capsules (ELP) are typical mucoactive drugs used in chronic rhinosinusitis with nasal polyps (CRSwNP). However, reliable evidence regarding its efficacy in this population remains limited…
View article: Cost‐effectiveness of subcutaneous immunotherapy for house dust mite‐induced allergic rhinitis in China
Cost‐effectiveness of subcutaneous immunotherapy for house dust mite‐induced allergic rhinitis in China Open
Background Limited cost‐effectiveness studies have evaluated the long‐term efficacy of subcutaneous immunotherapy (SCIT). Objective This study's objective was to analyze the cost‐effectiveness of house dust mite‐specific SCIT (HDM‐SCIT), i…
View article: Variability of Diagnostic Outcomes in Nasal Allergen Challenge: The Role of Combined Subjective and Objective Indicators
Variability of Diagnostic Outcomes in Nasal Allergen Challenge: The Role of Combined Subjective and Objective Indicators Open
Background Nasal allergen challenge (NAC) is currently the only available test to confirm nasal responsiveness to allergens and is a core diagnostic tool for allergic rhinitis. NAC is currently diagnosed by combining existing subjective me…
View article: Post-pandemic mental health: Understanding the global psychological burden and charting future research priorities
Post-pandemic mental health: Understanding the global psychological burden and charting future research priorities Open
The coronavirus disease 2019 pandemic has left an indelible mark on global mental health, with widespread psychological consequences that persist beyond the acute phase of the virus. This review synthesizes current evidence on the post-pan…
View article: Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint
Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint Open
Acylcarnitine accumulation is a characteristic of RA FLS metabolic fingerprint and could be linked to mitochondrial dysfunction. In patients with early RA, acylcarnitine content in serum decreases after successful anti-rheumatic treatment.…
View article: Efficacy and Safety of Combined Pharmacotherapies in Moderate‐to‐Severe Allergic Rhinitis: A Network Meta‐Analysis
Efficacy and Safety of Combined Pharmacotherapies in Moderate‐to‐Severe Allergic Rhinitis: A Network Meta‐Analysis Open
Background Combination pharmacotherapies are often selected for moderate‐to‐severe allergic rhinitis (AR), particularly when monotherapies do not control symptoms effectively. However, few studies have compared the efficacy and safety of d…
View article: Accelerated global burden of depressive disorders during the COVID-19 pandemic from 2019 to 2021
Accelerated global burden of depressive disorders during the COVID-19 pandemic from 2019 to 2021 Open
A thorough and current analysis of the burden and evolving trends in depressive disorders during the COVID-19 pandemic from 2019 to 2021 remains unavailable. Employing the Global Burden of Disease (GBD) 2021 database, we evaluated the burd…
View article: Immunomodulating platelet-mimicking nanoparticles for AIE-based enhanced photodynamic immunotherapy against lung cancer
Immunomodulating platelet-mimicking nanoparticles for AIE-based enhanced photodynamic immunotherapy against lung cancer Open
Lung cancer has become the leading cause of cancer related death worldwidely. Nowadays, immune checkpoint inhibitor (ICI) plays an important part in the treatment of lung cancer. However, immunologically cold tumor microenvironment (TME) h…
View article: Variant distribution and characterization of hereditary hemorrhagic telangiectasia in Chinese patients
Variant distribution and characterization of hereditary hemorrhagic telangiectasia in Chinese patients Open
Background Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder with variable manifestations, including recurrent epistaxis, telangiectasias, arteriovenous malformations, and family history. It is caused by heteroz…
View article: Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis
Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis Open
The incidence of PMOP was closely associated with fecal microbial compositions and intestinal functional changes. The present findings supported potential applications of gut microbiome analysis for early diagnosis of PMOP, and provided po…
View article: TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis Open
Taken together, the results of our study demonstrated that DAM-like cells were present in the acute phase of TBI in mice. TREM2 might influence DAM-like cell transformation by modulating the glycolysis of microglia. Our results provide a n…
View article: Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies
Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies Open
Ambient air pollution poses a significant yet manageable threat to human health. The growing consensus on the impact of ambient air pollutants on allergic rhinitis (AR) emphasizes the importance of prevention, control, and treatment strate…
View article: Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling
Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling Open
Proximity labeling techniques like TurboID and APEX2 have become pivotal tools in spatial omics research for studying protein interactions. However, the biochemical mechanisms underlying these reactive species-mediated labelings, particula…
View article: Comparative diagnostic efficacy of two-dimensional shear wave and transient elastography in predicting the risk of esophagogastric varices and histological staging in patients with primary biliary cholangitis
Comparative diagnostic efficacy of two-dimensional shear wave and transient elastography in predicting the risk of esophagogastric varices and histological staging in patients with primary biliary cholangitis Open
2D-SWE exhibited comparable performance to TE in predicting the risk of esophagogastric varices and histological staging.
View article: Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial
Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial Open
Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the…
View article: Research on Teaching Reform of Landscape Engineering Course based on the Concept of CDIO
Research on Teaching Reform of Landscape Engineering Course based on the Concept of CDIO Open
With the advancement of new engineering construction, it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs. In order to solve the …
View article: TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis Open
Background Traumatic brain injury (TBI) is characterized by high mortality and disability rates. Disease-associated microglia (DAM) are a newly discovered subtype of microglia. However, their presence and function in the acute phase of TBI…
View article: Blood and local eosinophil levels in chronic rhinitis: Observations during seasonal allergen exposure and non-exposure
Blood and local eosinophil levels in chronic rhinitis: Observations during seasonal allergen exposure and non-exposure Open
Blood eosinophil levels varied in patients with different subtypes of rhinitis. Patients with high blood eosinophil levels had more severe overall nasal and ocular symptoms, and that blood eosinophils levels were significantly higher in pa…
View article: Cancer Cachexia-related Monocytic MDSCs Impair T-cell Negative Selection and Predict Immune-related Adverse Events
Cancer Cachexia-related Monocytic MDSCs Impair T-cell Negative Selection and Predict Immune-related Adverse Events Open
Background Cancer cachexia is prevalent in multiple cancers and is associated with chemotherapy toxicity. However, data on the relationship between immune-related adverse events (irAEs) and cachexia are limited. Methods A murine model of o…
View article: Current challenges with adherence to pharmacotherapy in allergic rhinitis
Current challenges with adherence to pharmacotherapy in allergic rhinitis Open
KEYWORDS: Adherenceallergic rhinitisallergen-specific immunotherapybiologicspharmacotherapyreal-world evidence
View article: Echocardiographic assessment of left cardiac structure and function in ART-naïve people living with HIV/AIDS
Echocardiographic assessment of left cardiac structure and function in ART-naïve people living with HIV/AIDS Open
Background: Patients with human immunodeficiency virus (HIV) are at a significantly higher risk of cardiovascular disease (CVD) compared to HIV-negative people. Left heart dysfunction is the most common cardiac complication in people livin…