Yen‐Hung Lin
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View article: Comparison of Bacteriology Between Geriatric and Adult Rhinosinusitis with and Without NPs
Comparison of Bacteriology Between Geriatric and Adult Rhinosinusitis with and Without NPs Open
Background: In this study, we attempted to compare the bacteriology of chronic rhinosisusitis (CRS) with and without nasal polyps between geriatric and adult patients. Methods: This retrospective cross-sectional study included 751 patients…
View article: SUN-224 Interrogating the Distinction Between Low-Renin Hypertension and Primary Aldosteronism Using Angiotensin Converting Enzyme Inhibition
SUN-224 Interrogating the Distinction Between Low-Renin Hypertension and Primary Aldosteronism Using Angiotensin Converting Enzyme Inhibition Open
Disclosure: C. Tsai: None. J.M. Brown: None. S.P. Salle: None. A.J. Newman: None. V. Wu: None. Y. Lin: None. A. Vaidya: None. Background: Primary aldosteronism (PA) is a form of low-renin hypertension (LRH) characterized by inappropriate a…
View article: Diagnostic efficacy of magnifying endoscopy with blue laser imaging for laryngopharyngeal reflux
Diagnostic efficacy of magnifying endoscopy with blue laser imaging for laryngopharyngeal reflux Open
Objectives We aimed to analyze the utility of magnifying endoscopy with blue laser imaging (ME-BLI) in diagnosing laryngopharyngeal reflux (LPR). Methods The study enrolled 106 patients based on LPR-related symptoms. Using the reflux sympt…
View article: Clinical and Economic Evaluation of a Real-Time Chest X-Ray Computer-Aided Detection System for Misplaced Endotracheal and Nasogastric Tubes and Pneumothorax in Emergency and Critical Care Settings: Protocol for a Cluster Randomized Controlled Trial
Clinical and Economic Evaluation of a Real-Time Chest X-Ray Computer-Aided Detection System for Misplaced Endotracheal and Nasogastric Tubes and Pneumothorax in Emergency and Critical Care Settings: Protocol for a Cluster Randomized Controlled Trial Open
Background Advancements in artificial intelligence (AI) have driven substantial breakthroughs in computer-aided detection (CAD) for chest x-ray (CXR) imaging. The National Taiwan University Hospital research team previously developed an AI…
View article: Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism
Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism Open
Background The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary aldosteronism (PA). New guidelines recommend using these tests to predict the likelihood of unil…
View article: Real-World Characteristics and Treatment Patterns of Patients With Transthyretin Amyloid Cardiomyopathy: Protocol for a Multicountry Disease Registry Study
Real-World Characteristics and Treatment Patterns of Patients With Transthyretin Amyloid Cardiomyopathy: Protocol for a Multicountry Disease Registry Study Open
Background Transthyretin amyloid cardiomyopathy (ATTR-CM) is a systemic amyloidosis disorder with early clinical manifestations similar to other heart conditions, which complicates its diagnosis and management. The disease’s insidious natu…
View article: Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis
Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis Open
Background: In the context of the COVID-19 pandemic, there is growing concern about the virus’s effects on individuals with existing endocrine disorders such as primary aldosteronism (PA). Objectives: This study explores the potential rela…
View article: Proteomic signatures to detect unilateral primary aldosteronism in hypertensive patients
Proteomic signatures to detect unilateral primary aldosteronism in hypertensive patients Open
Context Primary aldosteronism (PA) is a major cause of hypertension and cardiovascular disease; however, diagnosing PA remains challenging. Objective We investigated whether deep proteomic analyses could be used to diagnose unilateral PA i…
View article: Blood pressure targets, medication considerations and special concerns in elderly hypertension: Focus on atherosclerotic cardiovascular diseases, atrial fibrillation, heart failure, and aortic stenosis
Blood pressure targets, medication considerations and special concerns in elderly hypertension: Focus on atherosclerotic cardiovascular diseases, atrial fibrillation, heart failure, and aortic stenosis Open
The management of hypertension in the elderly, particularly concerning atherosclerotic cardiovascular disease (ASCVD) and comorbidities, is crucial given its prevalence and impact on morbidity and mortality. It is important to individualiz…
View article: Definition, prevalence, and economic impacts of hypertension on the elderly population
Definition, prevalence, and economic impacts of hypertension on the elderly population Open
Arterial hypertension is the most important modifiable risk factor for cardiovascular disease and a leading cause of death. The incidence of hypertension increases with age, with a lifetime risk of more than 90% for elderly individuals. Wi…
View article: <b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b>
<b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b> Open
The association between KCNJ5 mutations and the risk of developing new-onset diabetes mellitus (NODM) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudin…
View article: Unilateral Primary Aldosteronism Lacking <i>KCNJ5</i> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus
Unilateral Primary Aldosteronism Lacking <i>KCNJ5</i> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus Open
The association between KCNJ5 mutations and the risk of developing new-onset diabetes mellitus (NODM) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudin…
View article: <b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b>
<b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b> Open
The association between KCNJ5 mutations and the risk of developing new-onset diabetes mellitus (NODM) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudin…
View article: C-terminal FGF-23 production coupling with aldosterone via FAM20C and predicting cardiovascular events in primary aldosteronism
C-terminal FGF-23 production coupling with aldosterone via FAM20C and predicting cardiovascular events in primary aldosteronism Open
This study examined the involvement of fibroblast growth factor-23 (FGF-23) in primary aldosteronism (PA), a condition characterized by elevated aldosterone levels and hypertension. We recruited patients with unilateral PA (uPA) and observ…
View article: 2025 Update Consensus of <sup>99m</sup>Tc-Pyrophosphate Scintigraphy in the Transthyretin Cardiac Amyloidosis from the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China.
2025 Update Consensus of <sup>99m</sup>Tc-Pyrophosphate Scintigraphy in the Transthyretin Cardiac Amyloidosis from the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China. Open
This 2025 updated consensus outlines the diagnostic strategy for transthyretin amyloid cardiomyopathy (ATTR-CM). Given that ATTR-CM is a significant contributor to heart failure, this article emphasizes the importance of making an early an…
View article: Effect of Tafamidis on Clinical and Functional Parameters in Transthyretin Amyloid Cardiomyopathy
Effect of Tafamidis on Clinical and Functional Parameters in Transthyretin Amyloid Cardiomyopathy Open
Tafamidis improves clinical outcomes and limits the progression of cardiac remodeling in ATTR-CM.
View article: Validating Machine Learning Models Against the Saline Test Gold Standard for Primary Aldosteronism Diagnosis
Validating Machine Learning Models Against the Saline Test Gold Standard for Primary Aldosteronism Diagnosis Open
In our discussion, we address both the strengths and limitations of our study. Although the machine learning models demonstrated superior performance in predicting primary aldosteronism, the generalizability of these findings may be limite…
View article: Implication of heart rhythm complexity in predicting long-term outcomes in pulmonary hypertension
Implication of heart rhythm complexity in predicting long-term outcomes in pulmonary hypertension Open
Pulmonary hypertension (PH) is a serious disease, however simple tools to predict outcomes are lacking. In our previous investigation, we found that heart rate variability (HRV) and heart rhythm complexity (HRC) were associated with the de…
View article: 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part II.
2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part II. Open
For the primary prevention of atherosclerotic cardiovascular disease (ASCVD), the recommended treatment target for each modifiable risk factor is as follows: reducing body weight by 5-10%; blood pressure < 130/80 mmHg (systolic pressure < …
View article: 2023 TSOC-TACVPR-TACPAH Consensus Statement of the Rehabilitation on Patients with Pulmonary Hypertension.
2023 TSOC-TACVPR-TACPAH Consensus Statement of the Rehabilitation on Patients with Pulmonary Hypertension. Open
In the past, patients with pulmonary hypertension (PH) were advised to avoid exercise due to concerns that it might strain cardiac function and exacerbate symptoms. However, recent evidence indicates that structured exercise programs can e…
View article: Neck triangle nerve enlargement in hereditary transthyretin amyloidosis correlates with changes in the autonomic, cardiac, and gastrointestinal systems
Neck triangle nerve enlargement in hereditary transthyretin amyloidosis correlates with changes in the autonomic, cardiac, and gastrointestinal systems Open
Background Hereditary transthyretin amyloidosis (ATTRv) is a hereditary disease that affects multiple bodily systems. Although sonography generally reveals enlargement of nerves in the limbs, the brachial plexus, and vagus nerve, the clini…
View article: Use of technetium-99m-pyrophosphate single-photon emission computed tomography/computed tomography in monitoring therapeutic changes of RNA interference therapeutics in patients with hereditary transthyretin amyloid cardiomyopathy
Use of technetium-99m-pyrophosphate single-photon emission computed tomography/computed tomography in monitoring therapeutic changes of RNA interference therapeutics in patients with hereditary transthyretin amyloid cardiomyopathy Open
Our results demonstrated a significant decrease in volumetric H/L ratio in hereditary ATTR-CA patients receiving RNA interference therapeutics.
View article: Blood pressure targets, medication consideration and unique concerns in elderly hypertension IV: Focus on frailty, orthostatic hypotension, and resistant hypertension
Blood pressure targets, medication consideration and unique concerns in elderly hypertension IV: Focus on frailty, orthostatic hypotension, and resistant hypertension Open
Hypertension increases the risk of cardiovascular disease in the elderly. Although treating hypertension can reduce the risk of cardiovascular disease and its related mortality, it is also challenging because these patients could have frai…