Yu Liu
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View article: Enzyme‐Assisted Selective Biosynthesis of Polyrotaxane Assemblies in Living Cells for Precision Supramolecular Phototherapy
Enzyme‐Assisted Selective Biosynthesis of Polyrotaxane Assemblies in Living Cells for Precision Supramolecular Phototherapy Open
In contrast to conventional bottom‐up self‐organization in an abiotic environment, it remains a formidable challenge to construct mechanically interlocked and biologically active supramolecules in cells and organisms. Notably, the in‐situ …
View article: Myocardial rhythm-mediated lipid metabolic dysfunction participates in adverse cardiac remodeling in offspring exposed to PM2.5 during conception
Myocardial rhythm-mediated lipid metabolic dysfunction participates in adverse cardiac remodeling in offspring exposed to PM2.5 during conception Open
Adverse pregnancy air pollution exposure is associated with abnormal cardiovascular development and function in early life. However, the effects of maternal inhalation exposure to PM2.5 on cardiac dysfunction and related molecular mechanis…
View article: Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis
Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis Open
Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of cancer. This review comprehensively examines the metabolic functions of MAOB within its dual implication…
View article: Dysfunctional locus coeruleus-cerebellum-cortex pathways in chronic low back pain: A resting-state functional magnetic resonance imaging and machine learning study
Dysfunctional locus coeruleus-cerebellum-cortex pathways in chronic low back pain: A resting-state functional magnetic resonance imaging and machine learning study Open
Our results suggest that impaired LC-cerebellar-cortical circuits mediate the modulation of emotions and chronic pain. Critically, support vector machine and logistic regression models demonstrated the potential of LC connectivity patterns…
View article: Genome-Wide Analysis of the Thiamine Biosynthesis Gene Families in Common Bean Reveals Their Crucial Roles Conferring Resistance to Fusarium Wilt
Genome-Wide Analysis of the Thiamine Biosynthesis Gene Families in Common Bean Reveals Their Crucial Roles Conferring Resistance to Fusarium Wilt Open
Fusarium wilt, caused by Fusarium oxysporum f. sp. phaseoli (Fop), is a major constraint to global common bean (Phaseolus vulgaris L.) production. Thiamine (vitamin B1), an essential coenzyme in plant metabolism, has recently emerged as a …
View article: Recent Advances and Challenges in Biomolecule-Based Laccase Mimics for Environmental Applications
Recent Advances and Challenges in Biomolecule-Based Laccase Mimics for Environmental Applications Open
Natural laccase is an environmentally friendly biocatalyst in the degradation of a broad range of toxic pollutants because its catalysis reaction does not require or produce toxic reactants and byproducts. However, its inherent limitations…
View article: Correction to “Zwitterionic Polysulfamide Drug Nanogels with Microwave Augmented Tumor Accumulation and On‐Demand Drug Release for Enhanced Cancer Therapy”
Correction to “Zwitterionic Polysulfamide Drug Nanogels with Microwave Augmented Tumor Accumulation and On‐Demand Drug Release for Enhanced Cancer Therapy” Open
View article: Injectable magnetic hydrogel induces multi-programmed cell death and deep tumor regression in magnetic hyperthermia therapy in hepatocellular carcinoma
Injectable magnetic hydrogel induces multi-programmed cell death and deep tumor regression in magnetic hyperthermia therapy in hepatocellular carcinoma Open
View article: Identification of antigen-specific functional CD8+ T cells using an optofluidic system independent of epitope information
Identification of antigen-specific functional CD8+ T cells using an optofluidic system independent of epitope information Open
View article: From Ulcer to Amputation: A Systematic Review of Prognostic Models for Diabetic Foot Ulcer Amputation
From Ulcer to Amputation: A Systematic Review of Prognostic Models for Diabetic Foot Ulcer Amputation Open
Risk prediction model research for diabetic foot ulcer progression to amputation remains in its early stages. Future efforts should prioritize prospectively developing and externally validating models with robust performance and low bias, …
View article: Effects of Clinacanthus nutans Extracts on Cell Proliferation and Apoptosis in Triple-Negative Breast Cancer: Mechanistic Insights
Effects of Clinacanthus nutans Extracts on Cell Proliferation and Apoptosis in Triple-Negative Breast Cancer: Mechanistic Insights Open
CnE inhibits TNBC cell proliferation, suppresses tumor growth, The mechanism likely involves multiple biological processes and pathways, Key pathways included apoptosis, ferroptosis, and necroptosis signaling.
View article: A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers
A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers Open
Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a compre…
View article: Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis
Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis Open
Glaesserella parasuis (GPS) is a Gram-negative, pathogenic bacterium that colonizes the upper respiratory tract of piglets and causes Glässer’s disease with peritonitis under stress conditions. The mechanism underlying GPS-induced peritoni…
View article: Advances of mRNA vaccines in genitourinary cancers
Advances of mRNA vaccines in genitourinary cancers Open
The rapid advancements and declining costs of mRNA technology have led to a significant rise in the use of mRNA-based interventions recently. Unlike traditional drug design schemes, mRNA vaccines rely on next-generation sequencing (NGS) re…
View article: Research on the Response Characteristics of Core Grounding Current Signals in Power Transformers Under Different Operating Conditions
Research on the Response Characteristics of Core Grounding Current Signals in Power Transformers Under Different Operating Conditions Open
This study delves into the response characteristics of core grounding current signals in power transformers across different operating conditions, aiming to enhance the accuracy of transformer condition assessment. Existing detection techn…
View article: Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation
Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation Open
The cyclic oligonucleotide-based antiphage signaling system (CBASS) is a bacterial immune mechanism that was evolutionarily linked to the eukaryotic cGAS–STING pathway, which protects against phage infection through abortive cell death. CB…
View article: Effect of Laser Scanning Speed on Microstructure and Wear Resistance of TiC-TiB2-Reinforced 316L Laser-Clad Coatings
Effect of Laser Scanning Speed on Microstructure and Wear Resistance of TiC-TiB2-Reinforced 316L Laser-Clad Coatings Open
To enhance the wear resistance of laser-clad coatings, this study investigates the underlying modulation mechanisms of scanning speed on the microstructure and properties of TiC-TiB2-reinforced 316L stainless steel composite coatings. TiC/…
View article: Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery
Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery Open
Gut biological information, including microbiota and metabolites, shows increasing associations with diseases such as inflammatory bowel disease, obesity, and diabetes. Precise sampling and modulation of biological information have become …
View article: Effects of Salinity Fluctuation on Antimicrobial Resistance and Virulence Factor Genes of Low and High Nucleic Acid-Content Bacteria in a Marine Environment
Effects of Salinity Fluctuation on Antimicrobial Resistance and Virulence Factor Genes of Low and High Nucleic Acid-Content Bacteria in a Marine Environment Open
Salinity, as one of the critical environmental factors in marine ecosystems, has complex and wide-ranging biological effects. However, the effects of salinity fluctuation on antibiotic resistance genes (ARGs) and virulence factor genes (VF…
View article: DNA large fragment deleting by compact, sequence-motif-free and specific TaqTth-hpRNA assisted with the microhomology-mediated end joining pathway
DNA large fragment deleting by compact, sequence-motif-free and specific TaqTth-hpRNA assisted with the microhomology-mediated end joining pathway Open
A DNA editing tool TaqTth-hpRNA was developed in this study, composed of a compact recombinant TaqTth nuclease (832 aa) and a simple hairpin-RNA guiding probe (hpRNA). In vitro biochemical studies showed the TaqTth-hpRNA efficiently cleave…
View article: Ionic liquid-mediated integration of NM88B in PVDF membranes: Synergistic enhancement of permeability and photocatalytic performance
Ionic liquid-mediated integration of NM88B in PVDF membranes: Synergistic enhancement of permeability and photocatalytic performance Open
NH2-MIL-88B (Fe) (NM88B), a promising photocatalyst for wastewater remediation, is hindered by particle agglomeration and unsustainable solvent usage in membrane fabrication. In this study, a green approach was developed through the integr…
View article: Microstructure and Mechanical Properties of Laser-Clad Inconel 718 Coatings on Continuous Casting Mold Copper Plate
Microstructure and Mechanical Properties of Laser-Clad Inconel 718 Coatings on Continuous Casting Mold Copper Plate Open
Mold copper plates (Cr–Zr–Cu alloy) frequently fail due to severe wear under high-temperature conditions during continuous casting. To solve this problem, Inconel 718 coatings were prepared on the plate surface via laser cladding to enhanc…
View article: A general approach to qualitatively and graphically characterize the diffuse behavior of interstitial nonmetallic atoms in multi‐principal element alloys based on site preference
A general approach to qualitatively and graphically characterize the diffuse behavior of interstitial nonmetallic atoms in multi‐principal element alloys based on site preference Open
It is urgent to establish a series of reasonable and general approaches to qualitatively and graphically characterize the four core effects of multi‐principal element alloys (MPEAs) based on the inherent site preference. In this contributi…
View article: Effect of B4C Content on Microstructure and Wear Resistance of Laser-Cladding-Enhanced 316 Stainless Steel Coatings
Effect of B4C Content on Microstructure and Wear Resistance of Laser-Cladding-Enhanced 316 Stainless Steel Coatings Open
This study investigates the effects of B4C content (2.5, 5, 7.5, and 10 wt.%) on the microstructure and wear resistance of laser cladding 316 stainless steel coatings on a 2Cr12MoV steel substrate. The coating was prepared by laser claddin…
View article: Multicolor Luminescent Supramolecular Bidirectional Shuttles Driven by Light
Multicolor Luminescent Supramolecular Bidirectional Shuttles Driven by Light Open
Possessing special photophysical behavior, supramolecular space‐confined assembly is widely applied in bioimaging, information anti‐counterfeiting, and luminescent materials. Herein, two different multicolor luminescent supramolecular bidi…
View article: Harnessing Photoredox Cascade to Enhance Photodynamic Oncotherapy by Nanoformulated Macrocyclic Photosensitizer
Harnessing Photoredox Cascade to Enhance Photodynamic Oncotherapy by Nanoformulated Macrocyclic Photosensitizer Open
View article: Expedient access to bora-butenolide bioisosteres by counteranion-mediated trans-hydroboration of alkynes
Expedient access to bora-butenolide bioisosteres by counteranion-mediated trans-hydroboration of alkynes Open
The hydroboration of alkynes is a textbook example of a syn -selective concerted addition reaction, while trans -selective additions of borane to alkynes remain to be developed. We herein report a transition metal-free anti -addition of pi…
View article: Potential scalp acupuncture and brain stimulation targets for common neurological disorders: evidence from neuroimaging studies
Potential scalp acupuncture and brain stimulation targets for common neurological disorders: evidence from neuroimaging studies Open
View article: Apelin/APJ alleviates diabetic nephropathy by improving glomerular endothelial cells dysfunction via SIRT3‑KLF15
Apelin/APJ alleviates diabetic nephropathy by improving glomerular endothelial cells dysfunction via SIRT3‑KLF15 Open
Glomerular basement membrane (GBM) thickening, the earliest morphological change of diabetic nephropathy (DN), is related to glomerular endothelial cells (GECs) dysfunction which increase extracellular matrix (ECM) synthesizing. Apelin, th…
View article: Antiviral covalent ACE2 vesicle spray
Antiviral covalent ACE2 vesicle spray Open