Yuichi Inoue
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View article: Plasma hepcidin level is elevated by water immersion‐induced central fatigue via hepatic inflammatory response in male and female rats
Plasma hepcidin level is elevated by water immersion‐induced central fatigue via hepatic inflammatory response in male and female rats Open
Fatigue is a subjective phenomenon caused by physical or mental overexertion; however, its objective biomarkers specific to the types of fatigue remain unclear. Here, we examined whether plasma hepcidin levels, which are regulated by infla…
View article: A Practical Two-Stage Recipe for Mathematical LLMs: Maximizing Accuracy with SFT and Efficiency with Reinforcement Learning
A Practical Two-Stage Recipe for Mathematical LLMs: Maximizing Accuracy with SFT and Efficiency with Reinforcement Learning Open
Enhancing the mathematical reasoning of Large Language Models (LLMs) is a pivotal challenge in advancing AI capabilities. While Supervised Fine-Tuning (SFT) and Reinforcement Learning (RL) are the dominant training paradigms, a systematic …
View article: Mapping research trends in obsessive-compulsive disorder before and after the COVID-19 pandemic: a bibliometric analysis focusing on its molecular mechanisms
Mapping research trends in obsessive-compulsive disorder before and after the COVID-19 pandemic: a bibliometric analysis focusing on its molecular mechanisms Open
Obsessive-compulsive disorder (OCD) is a psychiatric disorder that primarily develops during adolescence, and is characterized by obsessive thoughts and compulsive behaviors. Although multiple factors including heredity, environment, and a…
View article: 0878 A Two-Year Follow-Up Study on the Course of At-Risk Delayed Sleep-Wake Phase Disorder in the Young Generation
0878 A Two-Year Follow-Up Study on the Course of At-Risk Delayed Sleep-Wake Phase Disorder in the Young Generation Open
Introduction The prevalence of Delayed Sleep-Wake Phase Disorder (DSWPD) in the general population, especially among young people, and its impact on daytime functioning have been studied in various countries. However, there is currently a …
View article: Prevalence Rates of Frequent Dream Recall and Nightmares by Age, Gender and Sleep Duration in 16 Countries
Prevalence Rates of Frequent Dream Recall and Nightmares by Age, Gender and Sleep Duration in 16 Countries Open
The present study aimed to describe the prevalence rates of frequent (i.e., at least weekly) dream recall and nightmares with consideration for differences in age, gender and sleep duration in 16 countries using equivalent assessment metho…
View article: Clinical challenges in narcolepsy: From delayed diagnosis to daytime function impairments during treatment
Clinical challenges in narcolepsy: From delayed diagnosis to daytime function impairments during treatment Open
Improving sleepiness is crucial to optimize the patients' daytime functioning. A treatment system that addresses regional disparities in narcolepsy care is needed, along with increased public awareness, especially in educational settings.
View article: Efficacy and Safety of Intravenous-to-Oral Lascufloxacin Switch Therapy in Community-Onset Pneumonia: A Single-Arm, Open-Label Clinical Trial
Efficacy and Safety of Intravenous-to-Oral Lascufloxacin Switch Therapy in Community-Onset Pneumonia: A Single-Arm, Open-Label Clinical Trial Open
Switch therapy using LSFX presented high efficacy and acceptable safety profiles against mild-to-moderate severity of COP. This strategy of using the same drug in both intravenous and oral formulations is quite innovative. LSFX may potenti…
View article: Pharmacokinetics, safety, and efficacy of daridorexant in Japanese subjects: Results from phase 1 and 2 studies
Pharmacokinetics, safety, and efficacy of daridorexant in Japanese subjects: Results from phase 1 and 2 studies Open
Summary Daridorexant is a dual orexin receptor antagonist for the treatment of insomnia. We report results from the first two randomised, double‐blind clinical studies of daridorexant in Japanese subjects. In the Phase 1 study, daridorexan…
View article: Presenteeism and sleep duration on workdays and days off
Presenteeism and sleep duration on workdays and days off Open
Background Presenteeism refers to being present at work but experiencing reduced productivity due to health problems, and has been known to be related to sleep loss. Workers commonly sleep longer on days off than on workdays, and presentee…
View article: Heron-Bench: A Benchmark for Evaluating Vision Language Models in Japanese
Heron-Bench: A Benchmark for Evaluating Vision Language Models in Japanese Open
Vision Language Models (VLMs) have undergone a rapid evolution, giving rise to significant advancements in the realm of multimodal understanding tasks. However, the majority of these models are trained and evaluated on English-centric data…
View article: Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation
Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation Open
Temperature-dependent translational control of the core clock gene Per2 plays an important role in establishing entrainment of the circadian clock to physiological body temperature cycles. Previously, we found an involvement of the phospha…
View article: Cross‐sectional analyses of factors associated with the presence and aggravation of chronic insomnia by symptom subtypes
Cross‐sectional analyses of factors associated with the presence and aggravation of chronic insomnia by symptom subtypes Open
Aim The aim of this study was to investigate the association of psychological and chronobiological factors with the presence and severity of chronic insomnia by symptom subtypes and their impacts on daytime dysfunctions. Methods Participan…
View article: Efficacy and safety of lascufloxacin for nursing- and healthcare-associated pneumonia: A single-arm, open-label clinical trial
Efficacy and safety of lascufloxacin for nursing- and healthcare-associated pneumonia: A single-arm, open-label clinical trial Open
Oral LSFX is an acceptable treatment option for moderate NHCAP in elderly patients who can take oral medications.
View article: Evaluation of Large Language Models for Decision Making in Autonomous Driving
Evaluation of Large Language Models for Decision Making in Autonomous Driving Open
Various methods have been proposed for utilizing Large Language Models (LLMs) in autonomous driving. One strategy of using LLMs for autonomous driving involves inputting surrounding objects as text prompts to the LLMs, along with their coo…
View article: NuScenes-MQA: Integrated Evaluation of Captions and QA for Autonomous Driving Datasets using Markup Annotations
NuScenes-MQA: Integrated Evaluation of Captions and QA for Autonomous Driving Datasets using Markup Annotations Open
Visual Question Answering (VQA) is one of the most important tasks in autonomous driving, which requires accurate recognition and complex situation evaluations. However, datasets annotated in a QA format, which guarantees precise language …
View article: Anthropometric screening approach for obstructive sleep apnea in Japanese men: development and validation of the ABC scale
Anthropometric screening approach for obstructive sleep apnea in Japanese men: development and validation of the ABC scale Open
Background The existing screening tools for the detection of moderate and severe obstructive sleep apnea (OSA) are tailored to Western individuals. The aim of this study was to formulate and validate a simple anthropometric tool for OSA sc…
View article: The optimal dose of Ramelteon for the better treatment adherence of delayed sleep–wake phase disorder: a dropout rate study
The optimal dose of Ramelteon for the better treatment adherence of delayed sleep–wake phase disorder: a dropout rate study Open
Background Evidence regarding the effectiveness of melatonin receptor agonists in treating delayed sleep–wake phase disorder (DSWPD) remains limited. This study aimed to determine the optimal dose of ramelteon, a melatonin receptor agonist…
View article: Anthropometric screening approach for obstructive sleep apnea in Japanese men: development and validation of the ABC scale
Anthropometric screening approach for obstructive sleep apnea in Japanese men: development and validation of the ABC scale Open
Background The existing screening tools for the detection of moderate and severe obstructive sleep apnea (OSA) are tailored to Western individuals. The aim of this study was to formulate and validate a simple anthropometric tool for OSA sc…
View article: Delayed sleep–wake phase disorder and its related sleep behaviors in the young generation
Delayed sleep–wake phase disorder and its related sleep behaviors in the young generation Open
Delayed sleep–wake phase disorder (DSWPD) is a sleep disorder in which the habitual sleep–wake timing is delayed, resulting in difficulty in falling asleep and waking up at the desired time. Patients with DSWPD frequently experience fatigu…
View article: 0260 Establishment of a polysomnography databank for sleep disorders in Japan
0260 Establishment of a polysomnography databank for sleep disorders in Japan Open
Introduction Polysomnography (PSG) has been suggested to be useful as an objective indicator (biomarker) that contributes to the diagnosis and severity evaluation of various sleep disorders. However, its regular use is still limited to the…
View article: Serum exosomes contain filamentous alpha-synuclein and facilitate the propagation of Parkinson’s pathology
Serum exosomes contain filamentous alpha-synuclein and facilitate the propagation of Parkinson’s pathology Open
Parkinson’s disease (PD) is pathologically characterized by the deposition of a-synuclein (a-syn) containing Lewy bodies/neurites in both the central nervous system (CNS) and the peripheral nervous system (PNS). Recent evidence indicates t…
View article: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm
Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm Open
Body temperature in homeothermic animals does not remain constant but displays a regular circadian fluctuation within a physiological range (e.g., 35°C-38.5°C in mice), constituting a fundamental systemic signal to harmonize circadian cloc…