Yoshihiro Ishikawa
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View article: Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart.
Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart. Open
The regulatory mechanisms for inflammatory response in the heart to endotoxin, which causes severe cardiac dysfunction, are not fully understood. We hypothesized the involvement of coxsackie and adenovirus receptor (CXADR), which can promo…
View article: Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV Open
Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen tri…
View article: Evidence for the major role of PH4αEFB in the prolyl 4-hydroxylation of <i>Drosophila</i> collagen IV
Evidence for the major role of PH4αEFB in the prolyl 4-hydroxylation of <i>Drosophila</i> collagen IV Open
Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen tri…
View article: Identifying Mechanism-Based and Mechanism-Agnostic Interventions for Gould Syndrome †
Identifying Mechanism-Based and Mechanism-Agnostic Interventions for Gould Syndrome † Open
Gould syndrome is caused by mutations in the genes encoding collagen IV alpha 1 (COL4A1) and 2 (COL4A2)—fundamental basement membrane components that form collagen α1α1α2(IV) heterotrimers [...]
View article: Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored
Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored Open
Collagen embodies an intriguing paradox in protein biology. Despite being one of the most abundant protein superfamilies in vertebrates and having a seemingly simple structural organization, its biosynthesis is anything but straightforward…
View article: Collagen IV biosynthesis: Intracellular choreography of post-translational modifications
Collagen IV biosynthesis: Intracellular choreography of post-translational modifications Open
Collagen IV, an essential and evolutionarily conserved component of basement membranes, is one of the most extensively post-translationally modified proteins. Despite substantial research on fibrillar collagen biosynthesis, our understandi…
View article: Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure
Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure Open
β-Adrenergic receptor (β-AR) stimulation of the heart, leading to increased cardiac output, is mediated by cyclic AMP (cAMP), which induces protein kinase A (PKA)-mediated phosphorylation of the myofilament proteins troponin I (TnI) and my…
View article: Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation.
Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation. Open
Mutations in the collagen-modifying enzyme lysyl hydroxylase 1 (LH1) cause Warmblood Fragile Foal Syndrome (WFFS) in horses. We investigated the impact of this mutation on collagen structure and function. Our results show that LH1 deficien…
View article: Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure
Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure Open
β-Adrenergic receptor (β-AR) stimulation of the heart, leading to increased cardiac output, is mediated by cyclic AMP (cAMP), which induces protein kinase A (PKA)-mediated phosphorylation of the myofilament proteins troponin I (TnI) and my…
View article: Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming Open
Application of physical forces, ranging from ultrasound to electric fields, is recommended in various clinical practice guidelines, including those for treating cancers and bone fractures. However, the mechanistic details of such treatment…
View article: EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma
EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma Open
Lymph node metastasis, primarily caused by the migration of oral squamous cell carcinoma (OSCC) cells, stands as a crucial prognostic marker. We have previously demonstrated that EP4, a subtype of the prostaglandin E2 (PGE2) receptor, orch…
View article: Analysis of the Impact of Tourmaline and Terahertz-Infused Clothing on Heart Rate Variability
Analysis of the Impact of Tourmaline and Terahertz-Infused Clothing on Heart Rate Variability Open
Introduction: Expanding upon prior investigations that identified advantageous Far Infrared (FIR) properties associated with two minerals, namely tourmaline and terahertz, across diverse domains, including health and medicine. This study e…
View article: Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III
Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III Open
Mutations in the FKBP14 gene encoding the endoplasmic reticulum resident collagen-related proline isomerase FK506 binding protein 22 kDa (FKBP22) result in kyphoscoliotic Ehlers–Danlos Syndrome (EDS), which is characterized by a broad phen…
View article: Physiological functions of calcium signaling via Orai1 in cancer
Physiological functions of calcium signaling via Orai1 in cancer Open
Intracellular calcium (Ca2+) signaling regulates many cellular functions, including cell proliferation and migration, in both normal cells and cancer cells. Store-operated Ca2+ entry (SOCE) is a major mechanism by which Ca2+ is imported fr…
View article: ADVANCED RADIOACTIVE MATERIAL REMOVAL SYSTEM USING SILVER ZEOLITE (4) IMPROVED PERFORMANCE OF METAL FIBER FILTERS
ADVANCED RADIOACTIVE MATERIAL REMOVAL SYSTEM USING SILVER ZEOLITE (4) IMPROVED PERFORMANCE OF METAL FIBER FILTERS Open
Through the research of Filtered Containment Venting System (FCVS), air purification methods have been developed, such as technologies of scrubbing, metal fiber, silver zeolite and mobility. Using these technologies, we have been studying …
View article: Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts
Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts Open
Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs. The impairmen…
View article: Methotrexate-Transferrin-Functionalized Fe(Salen)-Polypyrrole Nanocomposites for Targeted Photo-/Magneto-Thermal Cancer Treatments
Methotrexate-Transferrin-Functionalized Fe(Salen)-Polypyrrole Nanocomposites for Targeted Photo-/Magneto-Thermal Cancer Treatments Open
Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous …
View article: FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis Open
Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary…
View article: Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis
Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis Open
Many studies have revealed numerous potential biomarkers for atherosclerosis, but tissue-specific biomarkers are still needed. Recent lineage-tracing studies revealed that smooth muscle cells (SMCs) contribute substantially to plaque forma…
View article: Aberrant binding of mutant HSP47 affects posttranslational modification of type I collagen and leads to osteogenesis imperfecta
Aberrant binding of mutant HSP47 affects posttranslational modification of type I collagen and leads to osteogenesis imperfecta Open
Heat shock protein 47 (HSP47), encoded by the SERPINH1 gene, is a molecular chaperone essential for correct folding of collagens. We report a homozygous p.(R222S) substitution in HSP47 in a child with severe osteogenesis imperfecta leading…
View article: Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus.
Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus. Open
Objective: COX inhibitors targeting smooth muscle cell (SMC) contraction represent the only pharmacological treatment for patent ductus arteriosus (PDA), but >30% patients are resistant to the current therapies. Intimal thickening (IT), oc…
View article: Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats
Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats Open
Colorectal anastomotic leakage is one of the most feared and fatal complications of colorectal surgery. To date, no external coating material that can prevent anastomotic leakage has been developed. As myoblasts possess anti-inflammatory c…
View article: Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts
Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts Open
There is urgent demand for biologically compatible vascular grafts for both adult and pediatric patients. The utility of conventional nonbiodegradable materials is limited because of their thrombogenicity and inability to grow, while autol…
View article: Sequence-dependent mechanics of collagen reflect its structural and functional organization
Sequence-dependent mechanics of collagen reflect its structural and functional organization Open
Extracellular matrix mechanics influence diverse cellular functions, yet surprisingly little is known about the mechanical properties of their constituent collagen proteins. In particular, network-forming collagen IV, an integral component…