Yoshito Itoh
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View article: The effects of different traction devices on colorectal endoscopic submucosal dissection outcomes
The effects of different traction devices on colorectal endoscopic submucosal dissection outcomes Open
Background: Endoscopic submucosal dissection (ESD) enables en bloc resection of large colorectal lesions, but it remains challenging due to thin walls and poor operability. Traction devices like SureClip traction band (SCTB, Micro-tech) an…
View article: Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study
Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study Open
Background/Objectives: This study aimed to identify specific endoscopic findings associated with the development of GC following successful H. pylori eradication. Methods: This prospective multicenter observational study included patients …
View article: Nivolumab plus Ipilimumab versus Lenvatinib or Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: CheckMate 9DW Japanese Subgroup Analysis
Nivolumab plus Ipilimumab versus Lenvatinib or Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: CheckMate 9DW Japanese Subgroup Analysis Open
Introduction: In the preplanned interim analysis of the phase 3 CheckMate 9DW trial, first-line nivolumab plus ipilimumab demonstrated significant overall survival (OS) benefit versus lenvatinib or sorafenib (hazard ratio [HR] = 0.79; 95% …
View article: Differences in complications between colonoscopy and esophagogastroduodenoscopy in Japan using large-scale health insurance claims data
Differences in complications between colonoscopy and esophagogastroduodenoscopy in Japan using large-scale health insurance claims data Open
Analyses of colonoscopy (CS) and esophagogastroduodenoscopy (EGD) complications is crucial for further promoting use of endoscopy. This study analyzed rates of severe complications of CS compared with those of EGD using big data. As a stud…
View article: Pure Well-differentiated Adenocarcinoma as a Safe Factor for Lymph Node Metastasis and Recurrence of T1 Colorectal Cancer
Pure Well-differentiated Adenocarcinoma as a Safe Factor for Lymph Node Metastasis and Recurrence of T1 Colorectal Cancer Open
PWDA can predict safety against LNM and recurrence in patients with T1 colorectal cancer.
View article: An Additional 30-s Observation of the Right-Sided Colon Using a Novel Endoscopic System with Texture and Color Enhancement Imaging Decreases Polyp Miss Rates: A Multicenter Study
An Additional 30-s Observation of the Right-Sided Colon Using a Novel Endoscopic System with Texture and Color Enhancement Imaging Decreases Polyp Miss Rates: A Multicenter Study Open
Background/Objectives: White light imaging (WLI) of colonoscopy has a 26% adenoma miss rate. We aimed to evaluate the effectiveness of an additional 30 s (Add-30s) observation of the right-sided colon using a novel system (EVIS X1; Olympus…
View article: Gel Immersion Endoscopic Submucosal Dissection Using a Scissor‐type Knife for Superficial Non‐ampullary Duodenal Epithelial Tumors
Gel Immersion Endoscopic Submucosal Dissection Using a Scissor‐type Knife for Superficial Non‐ampullary Duodenal Epithelial Tumors Open
Objectives This study aimed to compare the short‐term therapeutic outcomes between conventional endoscopic submucosal dissection (C‐ESD) and gel immersion ESD (GI‐ESD) for superficial non‐ampullary duodenal epithelial tumors (SNADETs). Met…
View article: Improvement of Colonoscopic Image Quality Using a New LED Endoscopic System with Specialized Noise Reduction
Improvement of Colonoscopic Image Quality Using a New LED Endoscopic System with Specialized Noise Reduction Open
Background/Objectives: A new LED endoscopy system featuring advanced noise-reduction technology, the EP-8000 with the EC-860ZP colonoscope (Fujifilm), was introduced in 2024. We evaluated the improvements in colonoscopic image quality of t…
View article: H&E Style Translation Using CycleGAN for Deep Ultraviolet-Excitation Fluorescence Images of Pancreatic Endoscopic Ultrasound-Fine Needle Aspiration/Biopsy Toward Slide-Free Rapid Pathology
H&E Style Translation Using CycleGAN for Deep Ultraviolet-Excitation Fluorescence Images of Pancreatic Endoscopic Ultrasound-Fine Needle Aspiration/Biopsy Toward Slide-Free Rapid Pathology Open
Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is critical for determining treatment strategies for patients with pancreatic cancer. However, conventional pathological examination using hematoxylin and eosin (H&E) s…
View article: The Comparison Between Low‐ and High‐Concentration Injection Solution Ability for Colorectal Endoscopic Submucosal Dissection
The Comparison Between Low‐ and High‐Concentration Injection Solution Ability for Colorectal Endoscopic Submucosal Dissection Open
Background and Aim Injection solution is important for achieving submucosal elevation in endoscopic submucosal dissection (ESD) and various viscous solutions categorized as low‐concentration injection solution (LCS) or high‐concentration i…
View article: Peroral Endoscopic Tumor Resection for Esophageal Leiomyoma with Accumulation of Fluorine-18-Fluorodeoxyglucose: A Case Report
Peroral Endoscopic Tumor Resection for Esophageal Leiomyoma with Accumulation of Fluorine-18-Fluorodeoxyglucose: A Case Report Open
Introduction: Esophageal leiomyomas are relatively common benign esophageal submucosal tumors (SMTs). Generally, benign tumors do not accumulate fluorine-18-fluorodeoxyglucose (FDG), but it is not rare for FDG to accumulate in uterine, duo…
View article: Risk Factors, Clinical Course, and Management of Delayed Perforation After Colorectal Endoscopic Submucosal Dissection: A Large-Scale Multicenter Study
Risk Factors, Clinical Course, and Management of Delayed Perforation After Colorectal Endoscopic Submucosal Dissection: A Large-Scale Multicenter Study Open
This study identified DP incidence and risk factors after colorectal ESD, with some cases requiring surgery. Endoscopic treatment may prevent surgery.
View article: Oleic acid enhances the proliferation of gallbladder cancer cells via the GPR120/ERK pathway
Oleic acid enhances the proliferation of gallbladder cancer cells via the GPR120/ERK pathway Open
Gallbladder cancer (GBC) is a highly aggressive malignancy exhibiting a correlation between increased body mass index and increased risk of developing GBC. In obese individuals, the release of free fatty acids from the adipose tissue into …
View article: Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells
Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in the world. Neoadjuvant chemotherapy (NAC) has become a standard treatment for patients scheduled for surgical resection, but the high rate of postoperative recurren…
View article: Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer
Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer Open
Cancer cachexia is a complex disorder characterized by skeletal muscle loss, which may influence the prognosis of patients with cancer. The cachexia index (CXI) is a new index for cachexia. The present study aimed to assess whether the CXI…
View article: Endoscopic hemostasis with a self‐assembling peptide gel during endoscopic submucosal dissection and cold‐snare polypectomy in the duodenum: Prospective exploratory study (with video)
Endoscopic hemostasis with a self‐assembling peptide gel during endoscopic submucosal dissection and cold‐snare polypectomy in the duodenum: Prospective exploratory study (with video) Open
Objectives A novel self‐assembling peptide gel (SAPG) was recently developed for hemostasis during endoscopic resection (ER) as an alternative for electrocoagulation and clip placement. Therefore, this exploratory study aimed to evaluate t…
View article: Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease
Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease Open
Background: Various noninvasive tests can be used to identify high-risk groups of patients with metabolic dysfunction–associated steatotic liver disease/steatohepatitis (MASLD). In this study, we compared the diagnostic performance of seru…
View article: Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol
Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol Open
Introduction Non-alcoholic fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a phenotype of the metabolic syndrome in the liver and is clearly associated with metabolic abnormalities suc…
View article: Seasonal Variations and a Demographic Analysis of Digital Evacuation Incidence for Constipation Management: A Japanese Population-based Cohort Study
Seasonal Variations and a Demographic Analysis of Digital Evacuation Incidence for Constipation Management: A Japanese Population-based Cohort Study Open
Objective Digital evacuation (DE) is an intervention used to address severe constipation. Literature exists on easily administered laxatives; however, reports on mildly invasive DE usage are limited. This study aimed to elucidate the funda…
View article: Factors involved in gastroesophageal varix‐related events in patients with hepatitis C virus‐related compensated and decompensated cirrhosis after direct‐acting antiviral therapy
Factors involved in gastroesophageal varix‐related events in patients with hepatitis C virus‐related compensated and decompensated cirrhosis after direct‐acting antiviral therapy Open
Aim The incidence of and factors involved in gastroesophageal varix‐related events in hepatitis C virus‐related cirrhosis patients, including decompensated cirrhosis, after direct‐acting antiviral therapy are unclear. Methods We conducted …
View article: Viscosity Characteristics of Ideal Lubricants to Reduce Stress on Intestinal Mucosa During Balloon‐Assisted Enteroscopy
Viscosity Characteristics of Ideal Lubricants to Reduce Stress on Intestinal Mucosa During Balloon‐Assisted Enteroscopy Open
Balloon‐assisted enteroscopy (BAE) is highly invasive and carries a higher risk of complications such as pain and perforation during enteroscope insertion. Applying lubricants to the small intestinal mucosa and reducing the dynamic frictio…
View article: Prognostic performance of a two‐step method using the Fibro‐Scope system for metabolic dysfunction‐associated steatotic liver disease
Prognostic performance of a two‐step method using the Fibro‐Scope system for metabolic dysfunction‐associated steatotic liver disease Open
Aim Fibro‐Scope is an artificial intelligence/neural network system for the noninvasive diagnosis of hepatic fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease. We aimed to examine the diagnostic performance…
View article: Clinical Utility of Genetic Variants in <i>PNPLA3</i> and <i>TM6SF2</i> to Predict Liver‐Related Events in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Clinical Utility of Genetic Variants in <i>PNPLA3</i> and <i>TM6SF2</i> to Predict Liver‐Related Events in Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Background and Aims Fibrosis‐4 (FIB‐4) index and genetic polymorphisms have been used in assessing the risk of liver‐related events (LRE) in metabolic dysfunction‐associated steatotic liver disease (MASLD). To establish a more efficient pr…
View article: High‐Performance Dedicated Snares with Tip Attachments can Overcome Current Disadvantages in Cold Snare Polypectomy
High‐Performance Dedicated Snares with Tip Attachments can Overcome Current Disadvantages in Cold Snare Polypectomy Open
Cold snare polypectomy (CSP) has the disadvantage of a lower histopathological complete resection rate (HCRR) because blunt resection using CSP‐dedicated snares (DSs) causes mucosal retraction into the sheath during capture/resection. In t…
View article: Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation
Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation Open
Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that se…
View article: Non-polypoid Colorectal Lesions Detection and False Positive Detection by Artificial Intelligence under Blue Laser Imaging and Linked Color Imaging
Non-polypoid Colorectal Lesions Detection and False Positive Detection by Artificial Intelligence under Blue Laser Imaging and Linked Color Imaging Open
AI finetuned by appropriate LS detected non-reddish and non-polypoid polyps under LCI.