Edmund Tsui
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View article: Report of a case of nasal-type extranodal NK/T-cell lymphoma with ciliary body involvement and literature review of interleukin-10 and interleukin-6 in intraocular T-cell lymphoma
Report of a case of nasal-type extranodal NK/T-cell lymphoma with ciliary body involvement and literature review of interleukin-10 and interleukin-6 in intraocular T-cell lymphoma Open
Purpose: To present a presumed case of NK/T-cell lymphoma with ciliary body involvement, emphasizing key clinical findings and diagnostic testing that facilitated differentiation from anterior uveitis. Methods: Retrospective case report an…
View article: Development of the advised protocol for OCT study terminology and elements anterior segment OCT extension reporting guidelines (APOSTEL-AS): Study protocol
Development of the advised protocol for OCT study terminology and elements anterior segment OCT extension reporting guidelines (APOSTEL-AS): Study protocol Open
Background Anterior segment optical coherence tomography (AS-OCT) is emerging as a valuable diagnostic, monitoring and predictive tool. Clinical utility has been suggested for ophthalmic disorders such as glaucoma, corneal disease, catarac…
View article: Immune Checkpoint Inhibitor-Associated Uveitis: Predictors and Survival Impact
Immune Checkpoint Inhibitor-Associated Uveitis: Predictors and Survival Impact Open
In 5966 patients treated with immune checkpoint inhibitors, uveitis was rare (0.49%) but linked to combination therapy, greater cumulative exposure, and prior uveitis. Uveitis occurrence was correlated with longer survival, suggesting heig…
View article: Machine Learning for Predicting Recurrent Course in Uveitis Using Baseline Clinical Characteristics
Machine Learning for Predicting Recurrent Course in Uveitis Using Baseline Clinical Characteristics Open
Machine learning models, particularly random Forest, effectively identified patients at low risk of uveitis recurrence, offering high specificity. However, sensitivity remained limited, highlighting challenges in predicting infrequent even…
View article: Proposed Nomenclature for Landmarks in Anterior-Segment OCT
Proposed Nomenclature for Landmarks in Anterior-Segment OCT Open
Importance Anterior-segment optical coherence tomography (AS-OCT) has broad clinical and research utility. The utility of quantitative data derived from AS-OCT is, however, dependent on the quality and consistency of the cumulative evidenc…
View article: Time to Progression to Proliferative Diabetic Retinopathy in Patients With Type 2 Diabetes
Time to Progression to Proliferative Diabetic Retinopathy in Patients With Type 2 Diabetes Open
Importance Risk stratification of patients at risk of progression to proliferative diabetic retinopathy (PDR) enables earlier detection and more efficient allocation of health care resources. Objective To develop survival models to predict…
View article: Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics
Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics Open
The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importa…
View article: Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection
Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection Open
Purpose To describe a case of acute multifocal retinitis (AMR) and retinal vasculitis associated with Rickettsia typhi . Methods Case report. Results A 37-year-old previously healthy female presented with acute bilateral panuveitis that wa…
View article: Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors
Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors Open
Ophthalmic immune-related adverse events (Eye-irAEs) from immune checkpoint inhibitors can cause visual morbidity. The absence of standardized definitions for Eye-irAEs not only impedes the development of evidence-based treatments but also…
View article: Establishment of a Standard Technique for Determining Laser Flare Photometry Values during Assessment of Intraocular Inflammation
Establishment of a Standard Technique for Determining Laser Flare Photometry Values during Assessment of Intraocular Inflammation Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Large Language Models May Help Patients Understand Peer-Reviewed Scientific Articles About Ophthalmology: Development and Usability Study
Large Language Models May Help Patients Understand Peer-Reviewed Scientific Articles About Ophthalmology: Development and Usability Study Open
Background Adequate health literacy has been shown to be important for the general health of a population. To address this, it is recommended that patient-targeted medical information is written at a sixth-grade reading level. To make well…
View article: Evidence-based guidelines for drug dosing in intravitreal injections in silicone oil-filled eyes: Pharmacokinetics, safety, and optimal dosage
Evidence-based guidelines for drug dosing in intravitreal injections in silicone oil-filled eyes: Pharmacokinetics, safety, and optimal dosage Open
We evaluate the pharmacokinetics, safety, and optimal dosages of intravitreal agents in silicone oil (SO)-filled eyes, addressing challenges in administering such therapies. We assessed the pharmacological properties and safety profiles of…
View article: Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide
Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide Open
Purpose To identify weather variables associated with pathogens contributing to infectious conjunctivitis globally. Methods Sample collection and pathogen identification from patients with acute infectious conjunctivitis was performed from…
View article: Biomarker Detection and Validation for Corneal Involvement in Patients With Acute Infectious Conjunctivitis
Biomarker Detection and Validation for Corneal Involvement in Patients With Acute Infectious Conjunctivitis Open
Importance Infectious conjunctivitis can lead to corneal involvement and result in ocular morbidity. The identification of biomarkers associated with corneal involvement has the potential to improve patient care. Objective To identify biom…
View article: Managing a patient with uveitis in the era of artificial intelligence: Current approaches, emerging trends, and future perspectives
Managing a patient with uveitis in the era of artificial intelligence: Current approaches, emerging trends, and future perspectives Open
The integration of artificial intelligence (AI) with healthcare has opened new avenues for diagnosing, treating, and managing medical conditions with remarkable precision. Uveitis, a diverse group of rare eye conditions characterized by in…
View article: Large Language Models May Help Patients Understand Peer-Reviewed Scientific Articles About Ophthalmology: Development and Usability Study (Preprint)
Large Language Models May Help Patients Understand Peer-Reviewed Scientific Articles About Ophthalmology: Development and Usability Study (Preprint) Open
BACKGROUND Adequate health literacy has been shown to be important for the general health of a population. To address this, it is recommended that patient-targeted medical information is written at a sixth-grade reading level. To make wel…
View article: Development of the Advised Protocol for OCT Study Terminology and Elements Anterior Segment OCT extension reporting guidelines (APOSTEL-AS): Study protocol
Development of the Advised Protocol for OCT Study Terminology and Elements Anterior Segment OCT extension reporting guidelines (APOSTEL-AS): Study protocol Open
Background Anterior segment optical coherence tomography (AS-OCT) is emerging as a valuable diagnostic, monitoring and predictive tool. Clinical utility has been suggested for ophthalmic disorders such as glaucoma, corneal disease, catarac…
View article: Pathogen Surveillance for Acute Infectious Conjunctivitis
Pathogen Surveillance for Acute Infectious Conjunctivitis Open
Importance Acute infectious conjunctivitis is a common ocular condition with major public health consequences. Objective To assess regional variations and microbial etiologies of acute infectious conjunctivitis to guide treatment. Design, …
View article: The Use of Large Language Models to Generate Education Materials about Uveitis
The Use of Large Language Models to Generate Education Materials about Uveitis Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Heterogenous pathogen profile associated with acute conjunctivitis in Nepal
Heterogenous pathogen profile associated with acute conjunctivitis in Nepal Open
Background Infectious conjunctivitis is common in Nepal. Materials and Methods This prospective study recruited 60 patients with presumed acute infectious conjunctivitis from the B.P. Koirala Lions Center for Ophthalmic Studies in Kathmand…
View article: THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS
THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS Open
Purpose: To describe the clinical characteristics and multimodal imaging features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey–yellow chorioretinal lesions surrounded by smaller satellite do…