Lingyi Kong
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View article: KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis
KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis Open
Metastasis significantly impacts the mortality rate of non-small cell lung cancer (NSCLC) patients. Numerous microtubule-targeting agents (MTAs) reveal anti-metastatic efficacy, but the mechanism remains unclear. In this research, we emplo…
View article: Design principles of practical industrial-scale layered oxide cathodes with air/water stability for sustainable sodium-ion batteries
Design principles of practical industrial-scale layered oxide cathodes with air/water stability for sustainable sodium-ion batteries Open
Low-cost manganese-based oxides as promising cathodes for sodium-ion batteries still face significant challenges, including irreversible phase transition, air/water sensitivity, and low initial charge capacity. Herein, we precisely design …
View article: High Energy Density Heterostructured Sodium Layered Oxide Cathodes Enabled by Mechanical‐Chemical Coupling Effect
High Energy Density Heterostructured Sodium Layered Oxide Cathodes Enabled by Mechanical‐Chemical Coupling Effect Open
Designing cobalt‐free manganese‐based oxide cathode materials with high energy density and excellent stability is of great significance and a challenge. Here, we construct a P2/O3 core–shell heterostructured layered oxide cathode material …
View article: Glycemic Level Modifies the Relationship between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes Mellitus-Complicated Pregnancies
Glycemic Level Modifies the Relationship between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes Mellitus-Complicated Pregnancies Open
OBJECTIVETo examine whether glycemic level modifies the association between gestational weight gain (GWG) and pregnant outcomes in type 2 diabetes mellitus-complicated pregnancies.RESEARCH DESIGN AND METHODSIn this multicenter retrospectiv…
View article: Glycemic Level Modifies the Relationship Between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes–Complicated Pregnancies
Glycemic Level Modifies the Relationship Between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes–Complicated Pregnancies Open
OBJECTIVE To examine whether glycemic level modifies the association between gestational weight gain (GWG) and pregnancy outcomes in type 2 diabetes–complicated pregnancies. RESEARCH DESIGN AND METHODS This multicenter retrospective study …
View article: Glycemic Level Modifies the Relationship between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes Mellitus-Complicated Pregnancies
Glycemic Level Modifies the Relationship between Maternal Gestational Weight Gain and Neonatal Birth Weight in Type 2 Diabetes Mellitus-Complicated Pregnancies Open
OBJECTIVETo examine whether glycemic level modifies the association between gestational weight gain (GWG) and pregnant outcomes in type 2 diabetes mellitus-complicated pregnancies.RESEARCH DESIGN AND METHODSIn this multicenter retrospectiv…
View article: Optimal gestational weight gain in women with pregestational type 2 diabetes: a population-based cohort study in China
Optimal gestational weight gain in women with pregestational type 2 diabetes: a population-based cohort study in China Open
The current GWG guidelines may not fully suit T2DM pregnancies, particularly for overweight and obese women, highlighting the need for BMI-specific recommendations to optimize maternal and neonatal outcomes.
View article: Seasonal cycles of snow algal blooms intensify surface melting on Antarctic ice shelves
Seasonal cycles of snow algal blooms intensify surface melting on Antarctic ice shelves Open
Antarctic ice shelves play a pivotal role in global sea-level regulation, yet their sensitivity to temperature variations, freeze-thaw cycles, and biotic factors such as snow algae remains under-explored. This study addresses the critical …
View article: Gestational diabetes mellitus and adverse pregnancy outcomes increased on pandemic lockdown: a retrospective analysis
Gestational diabetes mellitus and adverse pregnancy outcomes increased on pandemic lockdown: a retrospective analysis Open
The pandemic lockdown adversely affected pregnancy outcomes. Therefore, targeted screening and clinical management for specific populations should be prioritized.
View article: Enhancing immunogenicity and release of in situ-generated tumor vesicles for autologous vaccines
Enhancing immunogenicity and release of in situ-generated tumor vesicles for autologous vaccines Open
In situ vaccination (ISV) strategies offer an innovative approach to cancer immunotherapy by utilizing drug combinations directly at tumor sites to elicit personalized immune responses. Tumor cell-derived extracellular vesicles (TEVs) in I…
View article: LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36
LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36 Open
Limb expression 1-like protein (LIX1L) is an essential player in liver disorders, but its function in metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC) progression remains obscure. Here, …
View article: Cycles of snow algal blooms and snowmelt intensify Antarctic ice shelf melting
Cycles of snow algal blooms and snowmelt intensify Antarctic ice shelf melting Open
Antarctic ice shelves play a pivotal role in global sea-level regulation, yet their sensitivity to temperature variations, freeze-thaw cycles, and biotic factors such as snow algae remains under-explored. This study addresses the critical …
View article: Reviving Sodium Tunnel Oxide Cathodes Based on Structural Modulation and Sodium Compensation Strategy Toward Practical Sodium‐Ion Cylindrical Battery
Reviving Sodium Tunnel Oxide Cathodes Based on Structural Modulation and Sodium Compensation Strategy Toward Practical Sodium‐Ion Cylindrical Battery Open
As a typical tunnel oxide, Na 0.44 MnO 2 features excellent electrochemical performance and outstanding structural stability, making it a promising cathode for sodium‐ion batteries (SIBs). However, it suffers from undesirable challenges su…
View article: Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis
Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis Open
Mixed lineage kinase domain-like pseudokinase (MLKL) initiates necroptosis and could serve as a therapeutic target related to a series of human diseases. Proteolysis-targeting chimeras (PROTACs) are useful tools for degrading pathological …
View article: Lefamulin Overcomes Acquired Drug Resistance via Regulating Mitochondrial Homeostasis by Targeting ILF3 in Hepatocellular Carcinoma
Lefamulin Overcomes Acquired Drug Resistance via Regulating Mitochondrial Homeostasis by Targeting ILF3 in Hepatocellular Carcinoma Open
Acquired resistance represents a critical clinical challenge to molecular targeted therapies such as tyrosine kinase inhibitors (TKIs) treatment in hepatocellular carcinoma (HCC). Therefore, it is urgent to explore new mechanisms and thera…
View article: The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis Open
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the common site of metastasis. The pulmonary microenvironment plays a pivotal role in the coloni…
View article: Stereoselective Synthesis of <i>β, γ‐</i>Fused Bicyclic <i>γ</i>‐Ureasultams via an Intramolecular Mannich and aza‐Michael Addition Cascade
Stereoselective Synthesis of <i>β, γ‐</i>Fused Bicyclic <i>γ</i>‐Ureasultams via an Intramolecular Mannich and aza‐Michael Addition Cascade Open
A novel approach has been developed for the synthesis of bicyclic β, γ ‐fused bicyclic γ ‐ureasultams containing two consecutive chiral centers through an intramolecular Mannich and aza‐Michael addition cascade of alkenyl sulfamides. The s…
View article: Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors
Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors Open
The coexistence of ferroptosis and other modes of death has great advantages in the treatment of cancers. A series of glutathione peroxidase 4 (GPX4) and cyclin-dependent kinase (CDK) dual inhibitors were designed and synthesized, given th…