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View article: PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8 <sup>+</sup> T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma
PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8 <sup>+</sup> T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) demonstrates suboptimal responses to current immune checkpoint inhibitors (ICIs), with objective response rates (ORRs) of merely 15–20%. The molecular mechanisms underlying these low ORRs remai…
View article: Perineural Invasion Worsens Long-Term Outcomes of Pancreatic Neuroendocrine Tumors Following Surgical Resection
Perineural Invasion Worsens Long-Term Outcomes of Pancreatic Neuroendocrine Tumors Following Surgical Resection Open
Background To define the impact of perineural invasion (PNI) on long-term survival of patients following curative-intent resection of pancreatic neuroendocrine tumors (pNETs). Patients and Methods Patients with pNETs who underwent curative…
View article: The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study
The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study Open
The association of inflammation and telomere length (TL) have drawn much attention. However, the association between the C-reactive protein-to-lymphocyte ratio (CLR) and TL has never been reported before. The authors aimed to investigate t…
View article: SAT-190 Efficacy And Safety Of Weekly PEGylated Recombinant Human Growth Hormone (Jintrolong) In Prepubertal Children With Turner Syndrome: 3-year Results From A Multicenter, Randomized Study In China
SAT-190 Efficacy And Safety Of Weekly PEGylated Recombinant Human Growth Hormone (Jintrolong) In Prepubertal Children With Turner Syndrome: 3-year Results From A Multicenter, Randomized Study In China Open
Disclosure: J. Chen: None. Y. Lv: None. H. Du: None. Y. Ma: None. L. Han: None. F. Luo: None. G. Li: None. L. Chen: None. B. Cao: None. M. Qin: None. C. Su: None. L. Wei: None. Q. Wang: None. P. Li: None. Z. Xu: None. R. Xie: None. X. Chen…
View article: Genome sequencing and experimental validation reveal the biocontrol activity of endophytic Bacillus velezensis XY3 against Colletotrichum fructicola
Genome sequencing and experimental validation reveal the biocontrol activity of endophytic Bacillus velezensis XY3 against Colletotrichum fructicola Open
Tea anthracnose, caused by Colletotrichum spp., is a prevalent foliar disease in the primary tea-planting regions of China. The conventional chemical control of tea anthracnose results in excessive fungicide residues, which constrain the e…
View article: Integrating Microbial Source Tracking to Unravel Impacts of Wastewater Discharge on Spatial Distribution of Riverine Microbial Community
Integrating Microbial Source Tracking to Unravel Impacts of Wastewater Discharge on Spatial Distribution of Riverine Microbial Community Open
Microbial communities play a pivotal role in material cycling, energy flow, and pollutant degradation within river ecosystems. Thus, gaining a clear understanding of how wastewater discharge affects microbial community structure and functi…
View article: Skin-adaptive focused flexible micromachined ultrasound transducers for wearable cardiovascular health monitoring
Skin-adaptive focused flexible micromachined ultrasound transducers for wearable cardiovascular health monitoring Open
Continuous monitoring of cardiovascular vital signs can reduce the incidence and mortality of cardiovascular diseases, yet cannot be implemented by current technologies because of device bulkiness and rigidity. Here, we report self-adhesiv…
View article: Diagnosing Faults of Pneumatic Soft Actuators Based on Multimodal Spatiotemporal Features and Ensemble Learning
Diagnosing Faults of Pneumatic Soft Actuators Based on Multimodal Spatiotemporal Features and Ensemble Learning Open
Soft robots demonstrate significant advantages in applications within complex environments due to their unique material properties and structural designs. However, they also face challenges in fault diagnosis, such as nonlinearity, time va…
View article: Design and experimentation of the nested pneumatic soft actuator for hand exoskeleton
Design and experimentation of the nested pneumatic soft actuator for hand exoskeleton Open
Frequent repetitive manual tasks in the manufacturing industry have contributed to a rise in hand motor dysfunction, negatively affecting both health and work efficiency. While rigid hand exoskeleton robots are effective, they are often he…
View article: A DeepSeek-powered locally deployed closed-loop system for enhancing quality control in electronic nursing documentation: development and clinical validation
A DeepSeek-powered locally deployed closed-loop system for enhancing quality control in electronic nursing documentation: development and clinical validation Open
Objectives To develop a locally deployed DeepSeek-powered closed-loop system for electronic nursing documentation quality control (QC) and evaluate its clinical efficacy through a multidimensional validation framework. Materials and Method…
View article: Visible Light‐Driven Photoredox Synthesis of Sulfonylated Benzimidazoisoquinolines via 10 <i>H</i>‐Phenothiazine‐Catalyzed Electron Donor–Acceptor Complexes
Visible Light‐Driven Photoredox Synthesis of Sulfonylated Benzimidazoisoquinolines via 10 <i>H</i>‐Phenothiazine‐Catalyzed Electron Donor–Acceptor Complexes Open
An unmodified 10 H ‐phenothiazine is directly utilized as an efficient photocatalyst to enable ready access to sulfonylated benzo[4,5]imidazo[2,1‐ a ]isoquinoline derivatives from N ‐allyl benzimidazoles and sulfonyl chlorides. The reactio…
View article: The relationship between estimated pulse wave velocity and 28-day mortality in patients with sA-AKI: a retrospective cohort analysis of the MIMIC-IV database
The relationship between estimated pulse wave velocity and 28-day mortality in patients with sA-AKI: a retrospective cohort analysis of the MIMIC-IV database Open
ePWV serves as an independent predictor of 28-day mortality in patients with SA-AKI. This metric offers prognostic insights to help clinicians identify high-risk patients early, enabling timely interventions and better clinical outcomes.
View article: The relationship between estimated pulse wave velocity and 28-day mortality in patients with acute kidney injury combined with congestive heart failure: a retrospective cohort analysis of the MIMIC-IV database
The relationship between estimated pulse wave velocity and 28-day mortality in patients with acute kidney injury combined with congestive heart failure: a retrospective cohort analysis of the MIMIC-IV database Open
ePWV was significantly associated with 28-day risk of death in patients with AKI-CHF and was a standalone forecasting factor of it.
View article: Immunomodulation and bone repair of 3D printed Seb/PCL scaffolds containing PDA coating
Immunomodulation and bone repair of 3D printed Seb/PCL scaffolds containing PDA coating Open
3D-printed polycaprolactone (PCL) scaffolds are widely used for bone tissue engineering but suffer from deficiencies such as difficulty in cell adhesion, lack of osteogenic activity, and immunomodulatory capacity. Enhancing the biological …
View article: Copper‐Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment
Copper‐Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment Open
Hepatic cancer is the leading cause of worldwide death due to lack of effective chemotherapy drugs. Cuproptosis is a novel regulated cell death and offers a new potential mechanism to eliminate hepatic cancer. In this study, it is found th…
View article: Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements
Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements Open
Although perinatal depression (PND) has garnered increasing attention, few specific pharmacological treatments exist, particularly for breastfeeding mothers concerned about antidepressant safety. The misconception that “natural is harmless…
View article: SelfMedHPM: Self Pre-training With Hard Patches Mining Masked Autoencoders For Medical Image Segmentation
SelfMedHPM: Self Pre-training With Hard Patches Mining Masked Autoencoders For Medical Image Segmentation Open
In recent years, deep learning methods such as convolutional neural network (CNN) and transformers have made significant progress in CT multi-organ segmentation. However, CT multi-organ segmentation methods based on masked image modeling (…
View article: Arbovirus Infections and Epigenetic Mechanisms; a Potential Therapeutic Target
Arbovirus Infections and Epigenetic Mechanisms; a Potential Therapeutic Target Open
Arboviruses are a group of arthropod‐borne viral pathogens that pose a significant threat to the public health system. The clinical manifestations associated with these viruses range from self‐limiting infections to life‐threatening disord…
View article: Establishing predictive models for malignant and inflammatory pulmonary nodules using clinical data and CT imaging features
Establishing predictive models for malignant and inflammatory pulmonary nodules using clinical data and CT imaging features Open
Our novel subgrouping models were able to effectively distinguish between inflammatory and malignant lung nodules using a reduced feature set. Our models could facilitate the accurate diagnosis of patients with potentially malignant lesion…
View article: Harnessing Self-Condensing Vinyl Copolymerization for Well-Defined Redox-Active Hyperbranched Polymers Enabled by Flow Chemistry
Harnessing Self-Condensing Vinyl Copolymerization for Well-Defined Redox-Active Hyperbranched Polymers Enabled by Flow Chemistry Open
The increased adoption of renewable power necessitates the development of grid-scale storage solutions, with aqueous redox flow batteries (RFBs) at the forefront. Despite their potential, performance degradation due to crossover typically …
View article: Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration Open
Subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells has demonstrated therapeutic potential in macular degeneration. However, its efficiency is limited in wet age-related macular degen…
View article: A Review of Research on the Employment Effects of China's Digital Economy
A Review of Research on the Employment Effects of China's Digital Economy Open
The development of digital economy has profoundly affected the scale, structure and quality of employment in China. Academic research around the employment effect of digital economy is increasing, but related studies are scattered and have…