Yuji Naito
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View article: Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study
Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study Open
Background/Objectives: This study aimed to identify specific endoscopic findings associated with the development of GC following successful H. pylori eradication. Methods: This prospective multicenter observational study included patients …
View article: Effects of Dietary Fiber Supplementation on Gut Microbiota and Bowel Function in Healthy Adults: A Randomized Controlled Trial
Effects of Dietary Fiber Supplementation on Gut Microbiota and Bowel Function in Healthy Adults: A Randomized Controlled Trial Open
This randomized, double-blind, controlled trial evaluated the effects of 4-week dietary fiber supplementation on gut microbiota, bowel-related quality of life, and secondary outcomes, including sleep and skin condition. A total of 105 heal…
View article: Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial
Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial Open
Chronic kidney disease (CKD) is a life-threatening condition, and constipation is a progressive risk factor. We evaluated changes in uremic toxins, renal function, and the safety of lubiprostone, a selective chloride channel activator, in …
View article: Effects of Blackcurrant Extract and Partially Hydrolyzed Guar Gum Intake on Gut Dysbiosis in Male University Rugby Players
Effects of Blackcurrant Extract and Partially Hydrolyzed Guar Gum Intake on Gut Dysbiosis in Male University Rugby Players Open
Our previous study reported that male university rugby players tended to have a gut with a dysbiotic environment, characterized by abundant pathobiont bacteria and an accumulation of succinate, when compared with age-matched, non-rugby pla…
View article: Corrigendum to “Lansoprazole, a Proton Pump Inhibitor, Mediates Anti-Inflammatory Effect in Gastric Mucosal Cells through the Induction of Heme Oxygenase-1 via Activation of NF-E2-Related Factor 2 and Oxidation of Kelch-Like ECH-Associating Protein 1” [The Journal of Pharmacology and Experimental Therapeutics 331 (2009) 255-264]
Corrigendum to “Lansoprazole, a Proton Pump Inhibitor, Mediates Anti-Inflammatory Effect in Gastric Mucosal Cells through the Induction of Heme Oxygenase-1 via Activation of NF-E2-Related Factor 2 and Oxidation of Kelch-Like ECH-Associating Protein 1” [The Journal of Pharmacology and Experimental Therapeutics 331 (2009) 255-264] Open
View article: 300MO Puxitatug samrotecan (P-Sam, AZD8205) in patients (pts) with HR+/HER2– breast cancer (BC): A first-in-human phase I/IIa dose escalation and expansion study
300MO Puxitatug samrotecan (P-Sam, AZD8205) in patients (pts) with HR+/HER2– breast cancer (BC): A first-in-human phase I/IIa dose escalation and expansion study Open
View article: Synbiotic combination of <i>Bifidobacterium longum</i> BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study
Synbiotic combination of <i>Bifidobacterium longum</i> BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study Open
Gut microbiota and their metabolites are crucial for metabolic regulation, immunomodulation, and brain and mental functions via the brain-gut axis. Synbiotics offer an effective strategy for improving gut health by modulating gut microbiot…
View article: Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on intestinal permeability
Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on intestinal permeability Open
The intestinal barrier represents the first line of host defense. Its dysfunction, defined as increased intestinal permeability, is widely recognized as an important factor in the clinical manifestation of various diseases. Consequently, m…
View article: Analysis of Gut Microbiota and Their Metabolites in CADASIL Patients
Analysis of Gut Microbiota and Their Metabolites in CADASIL Patients Open
Both indole and Streptococcus species have been reported to be associated with atherosclerosis. Our results suggest that alterations in gut microbiota and their metabolites may be associated with the pathophysiology of CADASIL by pr…
View article: Functional independence during hospitalization in patients with intensive care unit-acquired weakness
Functional independence during hospitalization in patients with intensive care unit-acquired weakness Open
[Purpose] To examine the association between intensive care unit-acquired weakness and functional disability, specifically hospitalization-associated disability. [Participants and Methods] This post-hoc analysis of an investigation …
View article: Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study
Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study Open
View article: Association of Serum Bile Acid Profile with Diet and Physical Activity Habits in Japanese Middle-Aged Men
Association of Serum Bile Acid Profile with Diet and Physical Activity Habits in Japanese Middle-Aged Men Open
Background/Objectives: Circulating bile acid (BA) profiles change with lifestyle and are closely related to intestinal BA metabolisms such as deconjugation and conversion to secondary BAs. The composition of BA in the blood is involved in …
View article: Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study)
Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study) Open
Mobilization quantification score dose and muscle mass evaluation with ultrasonography will enable the quantification of the early mobilization intervention. This study will lay the foundation for future randomised studies.
View article: 食物繊維と大腸粘液
食物繊維と大腸粘液 Open
View article: Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis
Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis Open
View article: Effectiveness of Partially Hydrolyzed Guar Gum on Cognitive Function and Sleep Efficiency in Healthy Elderly Subjects in a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study
Effectiveness of Partially Hydrolyzed Guar Gum on Cognitive Function and Sleep Efficiency in Healthy Elderly Subjects in a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study Open
The consumption of functional foods in a daily diet is a promising approach for the maintenance of cognitive health. The present study examines the effects of water-soluble prebiotic dietary-fiber, partially hydrolyzed guar gum (PHGG), on …
View article: 1) Gut Microbiota and Lifestyle-related Diseases: Prospects for Prevention and Treatment
1) Gut Microbiota and Lifestyle-related Diseases: Prospects for Prevention and Treatment Open
View article: Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial
Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial Open
Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) show excessive peristalsis, and antispasmodic agents may be useful therapeutic agents. There are few reports on the use of Kampo medicines for the treatment of IBS-D. Shak…
View article: Role of gut microbiota in inflammatory bowel disease pathogenesis
Role of gut microbiota in inflammatory bowel disease pathogenesis Open
The role of the gut microbiota, especially bacterial flora, in the pathogenesis of inflammatory bowel disease (IBD) is becoming clearer. Advances in gut microbiota analysis and the use of gnotobiotics models have underscored the importance…
View article: Gut Frailty: Its Concept and Pathogenesis
Gut Frailty: Its Concept and Pathogenesis Open
Background: There is still a considerable gap between average life expectancy and healthy life expectancy in Japan. Recent research has revealed that gut frailty may be a worsening factor for various diseases, a cause of chro…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 46/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 46/2023 Open
…utilizing boron-mediated aglycon delivery (BMAD) is presented by Kazunobu Toshima, Daisuke Takahashi, and co-workers in their Research Article (e202307015).Theg lycosylations proceeded smoothly for av ariety of diols,triols, and unprotect…
View article: Conventional versus underwater endoscopic resection for superficial non-ampullary duodenal epithelial tumours
Conventional versus underwater endoscopic resection for superficial non-ampullary duodenal epithelial tumours Open
Background and objective Several endoscopic resection methods have been developed as less invasive treatments for superficial non-ampullary duodenal epithelial tumours. This study aimed to compare outcomes of conventional endoscopic mucosa…
View article: 715 Impact of COVID-19 on lung function and nutritional status in cystic fibrosis: a global observational study
715 Impact of COVID-19 on lung function and nutritional status in cystic fibrosis: a global observational study Open
View article: Correction: Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
Correction: Evidence-based clinical practice guidelines for irritable bowel syndrome 2020 Open
View article: High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study
High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study Open
Paramylon, a characteristic β-glucan of microalgae Euglena gracilis, modulates immune function. However, data on its mechanism of action and use in humans are limited. We conducted a 12-week randomized controlled trial to determine the eff…
View article: Reduction of butyric acid-producing bacteria in the ileal mucosa-associated microbiota is associated with the history of abdominal surgery in patients with Crohn’s disease
Reduction of butyric acid-producing bacteria in the ileal mucosa-associated microbiota is associated with the history of abdominal surgery in patients with Crohn’s disease Open
Fecal microbiota is a significant factor determining the cause, course, and prognosis of Crohn's disease (CD). However, the factors affecting mucosa-associated microbiota (MAM) remain unclear. This retrospective study examined the differen…
View article: Impact of Extra-Corporeal Membrane Oxygenation and Blood Purification Therapy on Early Mobilization in the Intensive Care Unit: Retrospective Cohort Study
Impact of Extra-Corporeal Membrane Oxygenation and Blood Purification Therapy on Early Mobilization in the Intensive Care Unit: Retrospective Cohort Study Open
Objective: To investigate the effect on early mobilization in patients undergoing extra-corporeal membrane oxygenation (ECMO) and acute blood purification therapy in the intensive care unit (ICU).Methods: We conducted this multicenter retr…
View article: Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells
Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells Open
Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity. We previously reported that conjunctival epithelial cel…
View article: Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production Open
View article: Association Between Intensive Care Unit-Acquired Weakness and Early Nutrition and Rehabilitation Intensity in Mechanically Ventilated Patients: A Multicenter Retrospective Observational Study
Association Between Intensive Care Unit-Acquired Weakness and Early Nutrition and Rehabilitation Intensity in Mechanically Ventilated Patients: A Multicenter Retrospective Observational Study Open