Yakeel T. Quiroz
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View article: Association between basal forebrain volume and age in the presenilin‐1 E280A autosomal dominant Alzheimer's disease kindred
Association between basal forebrain volume and age in the presenilin‐1 E280A autosomal dominant Alzheimer's disease kindred Open
INTRODUCTION The basal forebrain (BF), a key cholinergic hub, undergoes atrophy in Alzheimer's disease (AD), contributing to cognitive decline. However, its age‐related differences and early vulnerability in autosomal dominant AD (ADAD) re…
View article: The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium
The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium Open
On October 22nd, 2025, Brain Aging Symposium took place at Harvard Medical School bringing together leading researchers from academia and partner organizations to discuss recent advances in measuring and monitoring human brain aging trajec…
Contribution of local amyloid-β and tau burden to hypometabolism in autosomal-dominant Alzheimer’s disease Open
Glucose hypometabolism is observed in early Alzheimer’s disease. However, there are regional discrepancies in hypometabolism and Alzheimer’s pathological markers. We examined the local and global contributions of amyloid-β and tau patholog…
Thalamus but not basal forebrain and hippocampus atrophy in prodromal carriers of the Columbian mutation for autosomal dominant Alzheimer’s disease – a Bayesian confirmatory analysis Open
Background In sporadic Alzheimer's Disease (AD), the cholinergic basal forebrain degenerates early, but seems to be preserved in the Colombian PSEN1 ‐E280A genetic mutation for familial AD. In two cross‐sectional studies analyzing basal fo…
Sex Differences in Associations Between White Matter Microstructure and Cognitive Performance in the Boston Latino Aging Study Open
Background White matter deterioration is a potential early indicator of neurodegenerative diseases, often preceding cognitive symptoms. These critical brain tracts, essential for inter‐regional communication, are particularly susceptible t…
Estimated age of amyloid plaque onset and impact of APOE4 in longitudinally assessed presenilin 1 E280A autosomal dominant Alzheimer’s disease mutation carriers Open
Background We previously estimated the age of amyloid plaque onset at 28.2 years using florbetapir PET measurements of cerebral amyloid deposition in a cross‐sectional study of a convenience sample of PSEN1 E280A carriers and non‐carriers,…
Association among cerebral glucose metabolism, mild behavioral impairment and cognition in autosomal‐dominant Alzheimer’s disease Open
Background Neuropsychiatric symptoms, affecting 60%‐90% of dementia patients, are increasingly recognized early manifestations of disease. Mild behavioral impairment (MBI) is an emerging construct characterized by decreased motivation, aff…
Associations Among Handgrip Strength, Brain Pathology, and Cognition in Autosomal Dominant Alzheimer’s disease Open
Objective Grip strength decline, and cognitive impairment are prevalent in aging and may reflect shared underlying biological processes. This study examined associations between handgrip strength, brain pathology and cognition in individua…
View article: Distinct early cortical thickness patterns in heterozygous APOE3‐Christchurch carriers and age‐matched controls
Distinct early cortical thickness patterns in heterozygous APOE3‐Christchurch carriers and age‐matched controls Open
Background The APOE3‐Christchurch (APOE3 Ch ) variant has been linked to protection against Alzheimer’s disease (AD), even in the presence of substantial genetic and pathological risk factors. Although the exact mechanisms underlying this …
Muscle Function and Cognitive Performance in Autosomal Dominant AlzheimerDisease Insights from the PSEN1‐E280A Colombian Kindred Open
Background Carriers of the PSEN1‐E280A variant, the largest known autosomal dominant Alzheimer's disease (ADAD) cohort, typically experience mild cognitive impairment by age 44 and dementia by 49. Emerging evidence suggests gait speed (GS)…
View article: Distinct early cortical thickness patterns in heterozygous APOE3‐Christchurch carriers and age‐matched controls
Distinct early cortical thickness patterns in heterozygous APOE3‐Christchurch carriers and age‐matched controls Open
Background The APOE3‐Christchurch (APOE3 Ch ) variant has been linked to protection against Alzheimer's disease (AD), even in the presence of substantial genetic and pathological risk factors. Although the exact mechanisms underlying this …
Perceived social support and cognitive performance in preclinical autosomal dominant Alzheimer's disease Open
Background Perceived social support is an individual's sense of available emotional support from family and social networks. In neurodegenerative diseases, it has been explored as a potential protective factor against cognitive decline. Id…
The interactive influence of cortical amyloid levels and apathy symptoms on Digital Clock Test performance Open
Background The Digital Clock Test (DCT) is a novel, digitized version of the Clock Drawing Test that is sensitive to Alzheimer’s disease (AD) pathological burden (i.e., amyloid, tau) and cognitive impairment, yet provides a wealth of addit…
Impact of baseline amyloid and depressive symptom trajectory on longitudinal digital clock scores in community dwelling older adults Open
Background The digital clock drawing test (DCT) is a computerized measure examining executive functioning, information processing, and visuospatial abilities. DCT scores have been shown to discriminate well between mild cognitive impairmen…
Plasma biomarkers of neuroinflammation and neurodegeneration in relation to cerebral glucose hypometabolism in autosomal‐dominant Alzheimer’s disease Open
Background Cerebral glucose hypometabolism, measured with 18 F‐fluorodeoxyglucose (FDG) PET, is a hallmark of Alzheimer’s disease (AD). While FDG‐PET changes are highly effective at differentiating dementia types, the pathological bases fo…
LC‐EC Tract Degeneration is associated with Entorhinal Tau and Memory in Autosomal‐dominant Alzheimer’s Disease Open
Background The locus coeruleus (LC) is among the earliest regions accumulating tau in sporadic and autosomal dominant Alzheimer’s disease (AD‐AD), preceding tau in the entorhinal cortex (EC). A proposed mechanism of tau progression is alon…
Does Mood Matter: The impact of affective symptoms on the Digital Clock Test scores, a portable and sensitive screen for cognitive impairment Open
Background The Digital Clock Test (DCT) is a novel, computerized version of the clock drawing test (CDT). It has been shown to discriminate well between mild cognitive impairment and Alzheimer's disease (AD) dementia and has been associate…
Associations between Mild Behavioral Impairment and Functional Impairment in Cognitively Unimpaired Community‐dwelling Older Latinos Open
Background Latinos are 1.5 times more likely than non‐Latino Whites to be diagnosed with Alzheimer's Disease and Related Dementias (ADRD). Mild Behavioral Impairment (MBI), characterized by new neuropsychiatric symptoms in adults over 50, …
Plasma biomarkers of neuroinflammation and neurodegeneration in relation to cerebral glucose hypometabolism in autosomal‐dominant Alzheimer's disease Open
Background Cerebral glucose hypometabolism, measured with 18 F‐fluorodeoxyglucose (FDG) PET, is a hallmark of Alzheimer's disease (AD). While FDG‐PET changes are highly effective at differentiating dementia types, the pathological bases fo…
Mapping Strategies for Recruiting and Retaining US Hispanic/Latino Populations in AD/ADRD Clinical Trials and Longitudinal Research: A Scoping Review Open
Background Latinos represent the largest racial/ethnic minoritized group in the United States, yet their participation in Alzheimer's disease and related dementias (AD/ADRD) clinical trials and longitudinal research remains disproportionat…
View article: Associations between frequency of physical exercise and global cognition among community‐dwelling Latino older adults from the Boston Latino Aging Study
Associations between frequency of physical exercise and global cognition among community‐dwelling Latino older adults from the Boston Latino Aging Study Open
Background Latinos are 1.5 times more likely than non‐Latino Whites to develop Alzheimer's Disease and Related Dementias (ADRD). This increased risk is partly attributable to a higher prevalence of risk factors, though the exact connection…
Association among cerebral glucose metabolism, mild behavioral impairment and cognition in autosomal‐dominant Alzheimer's disease Open
Background Neuropsychiatric symptoms, affecting 60%‐90% of dementia patients, are increasingly recognized early manifestations of disease. Mild behavioral impairment (MBI) is an emerging construct characterized by decreased motivation, aff…
The Latin American Spanish Preclinical Alzheimer's Cognitive Composite (LAS‐PACC5): Adapted for Spanish‐Speaking Latino Populations Open
Background Validated cognitive assessments in Spanish are critical for evaluating Latino populations at risk for Alzheimer's disease (AD). To address this need, we developed a Latin American Spanish version of the Preclinical Alzheimer's C…
Early changes in basal forebrain volume and cognitive function in preclinical autosomal dominant Alzheimer's disease Open
Background The basal forebrain (BF), home to cholinergic neurons essential for attention and memory undergoes structural changes in sporadic Alzheimer's Disease and in at‐risk individuals, contributing to cognitive decline. To investigate …
Serum Lipidome as an Early Peripheral Indicator in Familial Alzheimer’s Disease Open
Protein biomarkers in biofluids are highly sensitive indicators of prodromal cognitive impairment yet remain limited for primary prevention. Lipids, essential to brain structure and function, offer untapped prognostic value. Here, we ident…
A scoping review of interventions for Hispanic caregivers of persons living with dementia Open
Dementia disproportionately affects Hispanic/Latino caregivers, and while some interventions exist, their consideration of intersectional factors remains unclear. Guided by PROGRESS‐Plus, a framework of health equity factors that affect be…
View article: Self-Reported Insomnia and Poor Sleep Quality Are Associated with Self-Reported Cognitive Changes in Older Adults
Self-Reported Insomnia and Poor Sleep Quality Are Associated with Self-Reported Cognitive Changes in Older Adults Open
Older adults are vulnerable to changes in sleep with age. Poor sleep quality is associated with self-reported cognitive changes, which can occur before the onset of objective cognitive decline associated with Mild Cognitive Impairment and …
Thalamus not basal forebrain is atrophied in non‐demented PSEN1 E280A carriers Open
INTRODUCTION A previous study of non‐demented presenilin‐1 (PSEN1) E280A carriers found basal forebrain and hippocampus, but not the thalamus, to be preserved. This study tested the hypothesis of preservation in an independent PSEN1 E280A …
Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic Open
Greater tau pathology amplified the association between living alone and increased loneliness among CU older adults during the COVID-19 pandemic. AD pathological brain changes may play an unrecognized role in late-life loneliness.