Yuri Rueda
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View article: Characterization of the Lipidome of Neurons in Mouse Brain Nuclei using Imaging Mass Spectrometry
Characterization of the Lipidome of Neurons in Mouse Brain Nuclei using Imaging Mass Spectrometry Open
Understanding the molecular composition of the brain at cellular level is essential for deciphering the metabolic alterations associated with brain diseases. Furthermore, the different prevalence of some neurological diseases between males…
View article: Using the Synergy between HPLC-MS and MALDI-MS Imaging to Explore the Lipidomics of Clear Cell Renal Cell Carcinoma
Using the Synergy between HPLC-MS and MALDI-MS Imaging to Explore the Lipidomics of Clear Cell Renal Cell Carcinoma Open
Lipid imaging mass spectrometry (LIMS) has been tested in several pathological contexts, demonstrating its ability to segregate and isolate lipid signatures in complex tissues, thanks to the technique's spatial resolution. However, it cann…
View article: Tri-Reagent Homogenate Is a Suitable Starting Material for UHPLC-MS Lipidomic Analysis
Tri-Reagent Homogenate Is a Suitable Starting Material for UHPLC-MS Lipidomic Analysis Open
Background: Transcriptomic and lipidomic dual analyses usually initiate with independent extractive procedures. That entails a difficulty in aligning results from both omics platforms, especially in the case of highly heterogeneous tissues…
View article: High-Resolution Human Kidney Molecular Histology by Imaging Mass Spectrometry of Lipids
High-Resolution Human Kidney Molecular Histology by Imaging Mass Spectrometry of Lipids Open
[Image: see text] For many years, traditional histology has been the gold standard for the diagnosis of many diseases. However, alternative and powerful techniques have appeared in recent years that complement the information extracted fro…
View article: A simple and reproducible method for quantification of human tear lipids with ultrahigh-performance liquid chromatography-mass spectrometry.
A simple and reproducible method for quantification of human tear lipids with ultrahigh-performance liquid chromatography-mass spectrometry. Open
IPA precipitation is an excellent procedure for extracting lipids from small tear volumes for quantitative large-scale, untargeted lipid profiling, which may be useful for identifying lipid biomarkers in tears from patients with different …
View article: High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice
High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice Open
High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD). The concurrence of experimental factors as fat content and source or total caloric i…
View article: Adenosine: Direct and Indirect Actions on Gastric Acid Secretion
Adenosine: Direct and Indirect Actions on Gastric Acid Secretion Open
Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed…
View article: Expression of Adenosine A2B Receptor and Adenosine Deaminase in Rabbit Gastric Mucosa ECL Cells
Expression of Adenosine A2B Receptor and Adenosine Deaminase in Rabbit Gastric Mucosa ECL Cells Open
Adenosine is readily available to the glandular epithelium of the stomach. Formed continuously in intracellular and extracellular locations, it is notably produced from ATP released in enteric cotransmission. Adenosine analogs modulate chl…