Young Hoon Ryu
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View article: Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition
Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition Open
INTRODUCTION With accumulating evidence that motor manifestations in Alzheimer's disease (AD) may emerge from AD pathology independent of other copathologies, we investigated the neural basis of motor dysfunction under the amyloid/tau/neur…
View article: Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis
Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis Open
Our findings established the potential of FDG PET/CT, enhanced with ML, in predicting MetS.
View article: Multifunctional cosmetic potential of extracellular vesicle‑like nanoparticles derived from the stem of <i>Cannabis sativa</i> in treating pigmentation disorders
Multifunctional cosmetic potential of extracellular vesicle‑like nanoparticles derived from the stem of <i>Cannabis sativa</i> in treating pigmentation disorders Open
While natural products and synthetic chemicals are used in functional cosmetics, their potential side effects remain a concern. This has driven the need for safer and more effective agents to treat skin disorders. This has driven the need …
View article: Predicting PET‐Based Amyloid and Tau Pathology Stages With Plasma Biomarkers in Alzheimer's disease
Predicting PET‐Based Amyloid and Tau Pathology Stages With Plasma Biomarkers in Alzheimer's disease Open
Background We aimed to investigate whether the quantitative analysis of plasma biomarkers could distinguish the pathology stages indicated by positron emission tomography (PET)‐based Thal phase of amyloid and Braak stage of tau. Method A t…
View article: Diagnostic Performance of Plasma Biomarkers for A/T/N Image Classification in Alzheimer's disease
Diagnostic Performance of Plasma Biomarkers for A/T/N Image Classification in Alzheimer's disease Open
Background We aimed to validate the ability of Alzheimer’s disease plasma biomarkers to predict clinical diagnosis and the ability to predict image‐based A/T/N biomarkers positivity in Asian population. We also sought to define the optimal…
View article: Correction to: The Development Status of PET Radiotracers for Evaluating Neuroinflammation
Correction to: The Development Status of PET Radiotracers for Evaluating Neuroinflammation Open
[This corrects the article DOI: 10.1007/s13139-023-00831-4.].
View article: The development status of PET radiotracers for evaluating neuroinflammation
The development status of PET radiotracers for evaluating neuroinflammation Open
Neuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determinati…
View article: Longitudinal changes of amyloid (A) and tau (T) image‐based biomarker in Alzheimer’s disease spectrum
Longitudinal changes of amyloid (A) and tau (T) image‐based biomarker in Alzheimer’s disease spectrum Open
Background To investigate long‐term changes in dichotomous profiles of amyloid (A) and tau (T) image‐based biomarker in Alzheimer’s disease (AD) spectrum. Method During the initial visit (V1), a total of 275 participants [96 cognitively un…
View article: Amyloid/Tau/Neurodegeneration (ATN) image‐based biomarker trajectories of Alzheimer’s disease through 5‐year longitudinal follow‐up
Amyloid/Tau/Neurodegeneration (ATN) image‐based biomarker trajectories of Alzheimer’s disease through 5‐year longitudinal follow‐up Open
Background To investigate the progression of Alzheimer’s disease (AD) in image‐based Amyloid/Tau/Neurodegeneration (ATN) biomarkers through 5‐year longitudinal follow‐up. Method Among the participants who completed 18 F‐florbetaben (FBB) f…
View article: Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum
Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum Open
Prolonged total sleep time was associated with tau accumulation in sleep-related cortical and subcortical areas as well as memory dysfunction. It also predicted faster disease progression with tau accumulation. Our study highlights the cli…
View article: Nigrosome 1 visibility and its association with nigrostriatal dopaminergic loss in Parkinson's disease
Nigrosome 1 visibility and its association with nigrostriatal dopaminergic loss in Parkinson's disease Open
Background Nigrosome 1 (NG1), a small cluster of dopaminergic cells in the substantia nigra and visible in the susceptibility map‐weighted magnetic resonance image (SMwI), is severely affected in Parkinson's disease (PD). However, the degr…
View article: Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis
Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis Open
Objective Although growing evidence suggests that perivascular space (PVS) serves as a clearance route for amyloid and tau, the association between enlarged PVS (EPVS) and Alzheimer disease is highly inconsistent across studies. As the con…
View article: Multimodal Imaging Findings of Cerebral Amyloid Angiopathy Related Inflammation With Unusual Clinical Manifestation: A Case Report
Multimodal Imaging Findings of Cerebral Amyloid Angiopathy Related Inflammation With Unusual Clinical Manifestation: A Case Report Open
Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare encephalopathy characterized by the coexistence of a perivascular inflammatory reaction in patients with cerebral amyloid angiopathy. CAA-RI diagnosis is challenging as it…
View article: Prediction of Microsatellite Instability in Colorectal Cancer Using a Machine Learning Model Based on PET/CT Radiomics
Prediction of Microsatellite Instability in Colorectal Cancer Using a Machine Learning Model Based on PET/CT Radiomics Open
Our predictive model incorporating PET radiomic features successfully identified the MSI status of CRC, and it also showed better performance than the conventional PET image parameters.
View article: 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence
18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence Open
Glucose utilization by visceral adipose tissue (VAT) reflects inflammatory activity, which also promotes tumor growth and carcinogenesis. The effect of metabolically active VAT on survival outcomes in breast cancer is unknown. We investiga…
View article: Image‐based primary age‐related tauopathy as a risk of dementia: a five‐year longitudinal study
Image‐based primary age‐related tauopathy as a risk of dementia: a five‐year longitudinal study Open
Background To investigate cognitive and pathological (amyloid and tau) changes of image‐based primary age‐related tauopathy (PART) in a long‐term follow‐up cohort study. Method In this study, a total of 108 patients who were both negative …
View article: Amyloid and tau PET imaging studies as a clinical prognostic marker in Alzheimer’s disease
Amyloid and tau PET imaging studies as a clinical prognostic marker in Alzheimer’s disease Open
Background To investigate prognostic value of amyloid (A) and tau (T) imaging biomarkers in a long term follow up cohort study. Method We included 273 AD spectrum participants [96 cognitive unimpaired (CU), 106 mild cognitive impairment (M…
View article: Prognostic Role of Pre-Treatment [18F]FDG PET/CT in Patients with Anaplastic Thyroid Cancer
Prognostic Role of Pre-Treatment [18F]FDG PET/CT in Patients with Anaplastic Thyroid Cancer Open
Anaplastic thyroid carcinoma (ATC) is a rare but highly lethal disease. Therefore, its diagnosis at an early stage and a rapid and accurate establishment of a proper treatment strategy is warranted. Tumor glycolysis assessed by 18fluorodeo…
View article: Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease
Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease Open
The findings of this prognostic study suggest that tau PET is a promising tool for predicting cognitive change that is superior to amyloid PET and MRI and may support the prognostic process in preclinical and prodromal stages of AD.
View article: MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment
MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment Open
A high degree of MR imaging-visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease-related cognitive impairment. Thus, MR imaging-visible perivascular spaces in …
View article: Combined Model of Aggregation and Network Diffusion Recapitulates Alzheimer's Regional Tau-Positron Emission Tomography
Combined Model of Aggregation and Network Diffusion Recapitulates Alzheimer's Regional Tau-Positron Emission Tomography Open
Background: Alzheimer's disease involves widespread and progressive deposition of misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer polymers and insoluble fibrils. There is mounting evidence for "pr…
View article: Late-Stage <sup>18</sup>F/<sup>19</sup>F Isotopic Exchange for the Synthesis of <sup>18</sup>F-Labeled Sulfamoyl Fluorides
Late-Stage <sup>18</sup>F/<sup>19</sup>F Isotopic Exchange for the Synthesis of <sup>18</sup>F-Labeled Sulfamoyl Fluorides Open
Synthesis of sulfamoyl [18F]fluorides has been a challenging topic owing to the inefficient nucleophilic radiofluorination of sulfamoyl derivatives. Herein, we report an 18F/19F isotopic exchange approach to synthesize various sulfamoyl [1…
View article: Effect of A/T/N imaging biomarkers on impaired odor identification in Alzheimer's disease
Effect of A/T/N imaging biomarkers on impaired odor identification in Alzheimer's disease Open
Background The contribution of A/T/N neuroimaging biomarkers to impaired odor identification ability in the Alzheimer’s disease spectrum was investigated Method We analyzed data from 127 participants who completed Cross‐Cultural Smell Iden…