Yusuke Sakaguchi
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View article: EXTH-11. Development of Topically Applied Fluorescent Probes for Intraoperative Diagnosis of Primary Central Nervous System Lymphoma
EXTH-11. Development of Topically Applied Fluorescent Probes for Intraoperative Diagnosis of Primary Central Nervous System Lymphoma Open
BACKGROUND Ring-enhancing lesions observed on gadolinium-enhanced MRI often include primary central nervous system lymphoma (PCNSL), metastatic brain tumors, and glioblastoma. Preoperative differentiation of these lesions remains challengi…
View article: Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models
Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models Open
Canine MSC derived EVs cultured in serum-free medium using AEX were successfully collected. Sustained release of canine MSC derived EVs suppresses cavity formation in the spinal cord after SCI and promotes improvement in motor function.
View article: Discontinuing renin-angiotensin system inhibitors after incident hyperkalemia and clinical outcomes: target trial emulation
Discontinuing renin-angiotensin system inhibitors after incident hyperkalemia and clinical outcomes: target trial emulation Open
Although renin-angiotensin system inhibitors (RASi) are the mainstay in the management of heart failure with reduced ejection fraction, chronic kidney disease, and other cardiovascular conditions, they are often discontinued due to hyperka…
View article: Psychological and Physical Stress Response and Incidence of Irregular Menstruation in Female University Employees: A Retrospective Cohort Study
Psychological and Physical Stress Response and Incidence of Irregular Menstruation in Female University Employees: A Retrospective Cohort Study Open
Psychological and physical stress response predicted irregular menstruation.
View article: Plant-Dominant Low-Protein Diets: A Promising Dietary Strategy for Mitigating Disease Progression in People with Chronic Kidney Disease—A Comprehensive Review
Plant-Dominant Low-Protein Diets: A Promising Dietary Strategy for Mitigating Disease Progression in People with Chronic Kidney Disease—A Comprehensive Review Open
Chronic kidney disease (CKD) is a global health crisis affecting over 10% of the population, with mortality rates increasing significantly. Current management strategies, including expensive medications and renal replacement therapies, hig…
View article: A Novel Heterozygous and Pathogenic Variant of the <i>HNF1B</i> Gene Associated with Autosomal Dominant Tubulointerstitial Kidney Disease with a Broad Spectrum of Extrarenal Phenotypes
A Novel Heterozygous and Pathogenic Variant of the <i>HNF1B</i> Gene Associated with Autosomal Dominant Tubulointerstitial Kidney Disease with a Broad Spectrum of Extrarenal Phenotypes Open
We encountered a family with hereditary renal failure, renal medullary cysts, pancreatic hypoplasia, hypomagnesemia, liver enzyme abnormalities, and diabetes mellitus (DM). We identified a novel heterozygous variant of HNF1B (NM_000458.4:c…
View article: 10122- NI-9 DEEP-LEARNING-BASED RECONSTRUCTION OF DIFFUSION WEIGHTED IMAGES OF MALIGNANT BRAIN TUMORS.
10122- NI-9 DEEP-LEARNING-BASED RECONSTRUCTION OF DIFFUSION WEIGHTED IMAGES OF MALIGNANT BRAIN TUMORS. Open
BACKGROUND Diffusion Kurtosis Imaging (DKI) is increasingly used to diagnose malignant brain tumors by assessing non-Gaussian diffusion of water molecules, reflecting tissue microstructure. It aids in preoperative molecular classification …
View article: Introduction of AI Technology for Objective Physical Function Assessment
Introduction of AI Technology for Objective Physical Function Assessment Open
Objective physical function assessment is crucial for determining patient eligibility for treatment and adjusting the treatment intensity. Existing assessments, such as performance status, are not well standardized, despite their frequent …
View article: Comparison of Vision Transformers and Convolutional Neural Networks in Medical Image Analysis: A Systematic Review
Comparison of Vision Transformers and Convolutional Neural Networks in Medical Image Analysis: A Systematic Review Open
View article: Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells
Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells Open
While fatty acid oxidation (FAO) in mitochondria is a primary energy source for quiescent lymphocytes, the impact of promoting FAO in activated lymphocytes undergoing metabolic reprogramming remains unclear. Here, we demonstrate that pemaf…
View article: Breakfast Frequency and Smoking Initiation in University Students: A Retrospective Cohort Study
Breakfast Frequency and Smoking Initiation in University Students: A Retrospective Cohort Study Open
Smoking causes various health problems. Limited studies have reported a clinical effect of skipping breakfast on smoking initiation among adolescents. This retrospective cohort study aimed to assess the dose-dependent association between s…
View article: Endogenous activation of peroxisome proliferator-activated receptor-α in proximal tubule cells in counteracting phosphate toxicity
Endogenous activation of peroxisome proliferator-activated receptor-α in proximal tubule cells in counteracting phosphate toxicity Open
This study revealed the activation of peroxisome proliferator-activated receptor-α and fatty acid β-oxidation in proximal tubular epithelial cells as an endogenous mechanism to protect the kidney from phosphate toxicity. These findings hig…
View article: #1397 Predictive factors for bioprosthetic valve stenosis and prognostic factors for survival following TAVR in hemodialysis patients with severe AS
#1397 Predictive factors for bioprosthetic valve stenosis and prognostic factors for survival following TAVR in hemodialysis patients with severe AS Open
Background and Aims Transcatheter aortic valve replacement (TAVR) is a promising option for the treatment of severe aortic valve stenosis (AS) in patients undergoing hemodialysis. Although the incidence of bioprosthetic valve deterioration…
View article: A bibliometric analysis of the 100 most-cited clinical articles in the research of intracranial artery stenosis and intracranial atherosclerosis
A bibliometric analysis of the 100 most-cited clinical articles in the research of intracranial artery stenosis and intracranial atherosclerosis Open
Background: Intracranial arterial stenosis (ICAS), caused by intracranial atherosclerosis, is one of the major causes of ischemic stroke. This study identified the top 100 most-cited publications on ICAS through a bibliometric analysis. Me…
View article: Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications
Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications Open
Surgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary tre…
View article: Development of a heat‐stable alkaline phosphatase reporter system for <i>cis</i>‐regulatory analysis and its application to 3D digital imaging of <scp><i>Xenopus</i></scp> embryonic tissues
Development of a heat‐stable alkaline phosphatase reporter system for <i>cis</i>‐regulatory analysis and its application to 3D digital imaging of <span><i>Xenopus</i></span> embryonic tissues Open
Xenopus is one of the essential model systems for studying vertebrate development. However, one drawback of this system is that, because of the opacity of Xenopus embryos, 3D imaging analysis is limited to surface structures, explant cultu…
View article: Association between urinary uric acid excretion and kidney outcome in patients with CKD
Association between urinary uric acid excretion and kidney outcome in patients with CKD Open
View article: The association between embedded catheter implantation and hospitalization costs for peritoneal dialysis initiation: a retrospective cohort study
The association between embedded catheter implantation and hospitalization costs for peritoneal dialysis initiation: a retrospective cohort study Open
Background Compared with the conventional peritoneal dialysis (PD) catheter insertion, embedding PD catheter implantation is one of the procedures for planned PD initiation. However, facilities where embedded PD catheter implantation is av…
View article: NIMG-80. SKULL BASE CHORDOMA: CORRELATION OF18F-FDG PET/CT FINDINGS WITH PATHOLOGICAL FEATURES AND CLINICAL COURSE
NIMG-80. SKULL BASE CHORDOMA: CORRELATION OF18F-FDG PET/CT FINDINGS WITH PATHOLOGICAL FEATURES AND CLINICAL COURSE Open
OBJECTIVE This study aimed to evaluate 18F-fluorodeoxyglucose (FDG)-PET/CT findings, histopathological results, and clinical outcomes in patients with skull base chordoma. METHODS This retrospective study included patients who underwent fi…
View article: Interstitial Eosinophilic Aggregates and Kidney Outcome in Patients with CKD
Interstitial Eosinophilic Aggregates and Kidney Outcome in Patients with CKD Open
Background Interstitial eosinophilic aggregates are observed in various kidney diseases, but their clinical implications remain unknown. We assessed the association between interstitial eosinophilic aggregates and kidney outcomes and furth…
View article: Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the <scp>CREDENCE</scp> trial
Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the <span>CREDENCE</span> trial Open
Aim To identify the mediators between canagliflozin and renoprotection in patients with type 2 diabetes at a high risk of end‐stage kidney disease (ESKD). Methods In this post hoc analysis of the CREDENCE trial, the effect of canagliflozin…
View article: Association of Longitudinal B-Type Natriuretic Peptide Monitoring With Kidney Failure in Patients With CKD: A Cohort Study
Association of Longitudinal B-Type Natriuretic Peptide Monitoring With Kidney Failure in Patients With CKD: A Cohort Study Open
View article: Hepatic phosphate uptake and subsequent nerve-mediated phosphaturia are crucial for phosphate homeostasis following portal vein passage of phosphate in rats
Hepatic phosphate uptake and subsequent nerve-mediated phosphaturia are crucial for phosphate homeostasis following portal vein passage of phosphate in rats Open
View article: Plant-Dominant Low Protein Diet: A Potential Alternative Dietary Practice for Patients with Chronic Kidney Disease
Plant-Dominant Low Protein Diet: A Potential Alternative Dietary Practice for Patients with Chronic Kidney Disease Open
Dietary protein restriction has long been a cornerstone of nutritional therapy for patients with chronic kidney diseases (CKD). However, the recommended amount of dietary protein intake is different across guidelines. This is partly becaus…
View article: A Randomized Controlled Trial of Whole-Body Vibration on Gait Ability and Balance among Older Hemodialysis Patients
A Randomized Controlled Trial of Whole-Body Vibration on Gait Ability and Balance among Older Hemodialysis Patients Open
Background Gait abnormality is a serious problem among hemodialysis patients. Whole-body vibration is a simple exercise that induces sustained muscular contractions through mechanical vibrations. This training improved gait ability in olde…
View article: A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects
A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects Open
The LAMA5 gene encodes laminin α5, an indispensable component of glomerular basement membrane and other types of basement membrane. A homozygous pathological variant in LAMA5 is known to cause a systemic developmental syndrome including gl…
View article: Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial
Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial Open
View article: Association between Time-Updated Eosinophil Counts and Progression of CKD
Association between Time-Updated Eosinophil Counts and Progression of CKD Open
Patients with chronic kidney disease (CKD) have high blood eosinophil count but its clinical implication is uncertain. Since eosinophils may induce tubulointerstitial injury and arteriosclerosis, eosinophilia might be related to poor clini…
View article: Preoperative hypomagnesemia as a possible predictive factor for postoperative increase of transvalvular pressure gradient in hemodialysis patients treated with transcatheter aortic valve implantation
Preoperative hypomagnesemia as a possible predictive factor for postoperative increase of transvalvular pressure gradient in hemodialysis patients treated with transcatheter aortic valve implantation Open
Among bone-mineral metabolism markers, preoperative hypomagnesemia was associated with the increase of MPG after TAVI, suggesting that hypomagnesemia could predict post-TAVI valve dysfunction in HD patients. Further studies with larger sam…
View article: Skipping Breakfast and Incidence of Frequent Alcohol Drinking in University Students in Japan: A Retrospective Cohort Study
Skipping Breakfast and Incidence of Frequent Alcohol Drinking in University Students in Japan: A Retrospective Cohort Study Open
Frequency of alcohol drinking is a potential predictor of binge drinking of alcohol, a serious social problem for university students. Although previous studies have identified skipping breakfast as a predictor of various health-compromisi…