Yusuke Shibuya
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View article: Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study
Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study Open
Epithelial ovarian cancer (EOC) is diagnosed at an advanced stage in over half of the patients and its prognosis remains unfavorable. CA125, one of the most frequent positive tumor markers in patients with EOC, has certain limitations. The…
View article: Asynchronous Batch Bayesian Optimization with Pipelining Evaluations for Experimental Resource$\unicode{x2013}$constrained Conditions
Asynchronous Batch Bayesian Optimization with Pipelining Evaluations for Experimental Resource$\unicode{x2013}$constrained Conditions Open
Bayesian optimization is efficient even with a small amount of data and is used in engineering and in science, including biology and chemistry. In Bayesian optimization, a parameterized model with an uncertainty is fitted to explain the ex…
View article: Area measure of skin conductance in the Concealed Information Test
Area measure of skin conductance in the Concealed Information Test Open
Skin conductance (SC) is one of the indices commonly used in the autonomic Concealed Information Test (CIT), but SC amplitude is sometimes difficult to quantify. This study investigated the applicability of SC area to the CIT as an unambig…
View article: Targeting Metabolic Vulnerability by Combining NAMPT Inhibitors and Disulfiram for Treatment of Recurrent Ovarian Cancer
Targeting Metabolic Vulnerability by Combining NAMPT Inhibitors and Disulfiram for Treatment of Recurrent Ovarian Cancer Open
Ovarian cancer (OV) has the highest mortality rate among gynecological cancers. As the OV progresses, tumor cells spread outside the ovaries to the peritoneal and abdominal cavities, forming cell clusters that float in the ascitic fluid ca…
View article: Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer Open
Ovarian cancer follows a characteristic progression pattern, forming multiple tumor masses enriched with cancer stem cells (CSCs) within the abdomen. Most patients develop resistance to standard platinum-based drugs, necessitating better t…
View article: Lenvatinib plus Pembrolizumab Combination Therapy for Advanced or Recurrent Endometrial Cancer: A Single-Center, Retrospective Analysis
Lenvatinib plus Pembrolizumab Combination Therapy for Advanced or Recurrent Endometrial Cancer: A Single-Center, Retrospective Analysis Open
A multi-kinase inhibitor, lenvatinib, plus an immune checkpoint inhibitor, pembrolizumab, became a viable therapeutic option for advanced or recurrent endometrial cancer in Japan by the end of 2021. The Japanese population has a relatively…
View article: Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer Open
Ovarian cancer follows a characteristic progression pattern, forming multiple tumor masses enriched with cancer stem cells (CSCs) within the abdomen. Most patients develop resistance to standard platinum-based drugs, necessitating better t…
View article: Improvement of discrimination method utilizing effect sizes to identify differential physiological responses in the Concealed Information Test
Improvement of discrimination method utilizing effect sizes to identify differential physiological responses in the Concealed Information Test Open
The concealed information test (CIT) is a memory detection technique that examines whether an examinee knows crime-relevant information. In Japanese field applications, an expert judge whether the examinee recognizes crime-relevant informa…
View article: Diagnostic Performance of Preoperative Imaging in Endometrial Cancer
Diagnostic Performance of Preoperative Imaging in Endometrial Cancer Open
Background: Endometrial cancer is one of the most common gynecological malignancies. Because the findings mentioned in radiogram interpretation reports issued by diagnostic radiologists influence treatment strategies, we aimed to evaluate …
View article: Hierarchical Bayesian Modeling of Autonomic Responses during the Concealed Information Test
Hierarchical Bayesian Modeling of Autonomic Responses during the Concealed Information Test Open
自律神経系生理指標を用いた隠匿情報検査では,皮膚コンダクタンス,規準化脈波容積,心拍数,呼吸などが連続的に測定される。本研究では,これらの生理反応の時系列データを分析するための階層ベイズモデルを提案した。提案手法では,切断正規分布を持つ観測方程式と階層構造を持つ状態方程式からなる状態空間モデルを利用した。提案手法を167名の実験データに適用して,その有効性を示した。提案手法により,データの標準化を要する従来の統計分析では見過ごされていた元の測定単位での典型的な生理反応の大き…
View article: SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling
SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling Open
The overexpression of inhibitor of apoptosis (IAP) proteins is strongly related to poor survival of women with ovarian cancer. Recurrent ovarian cancers resist apoptosis due to the dysregulation of IAP proteins. Mechanistically, Second Mit…
View article: Revisiting the diagnostic value of risk of ovarian malignancy algorithm (ROMA) for differential diagnosis of epithelial ovarian cancer
Revisiting the diagnostic value of risk of ovarian malignancy algorithm (ROMA) for differential diagnosis of epithelial ovarian cancer Open
Objective: Initial treatment decision between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS) for patients diagnosed with advanced ovarian cancer is still challenging.The purp…
View article: Assessing the Significance of Lymphadenectomy in Older Patients with Stage I Endometrial Cancer: A Single-Center, Retrospective Cohort Study
Assessing the Significance of Lymphadenectomy in Older Patients with Stage I Endometrial Cancer: A Single-Center, Retrospective Cohort Study Open
Advantages of lymphadenectomy for early stage endometrial cancer remain controversial. Lymphadenectomy had been routinely omitted for patients aged ≥ 70 years at our institute if lymph node metastasis was unsuspected due to an increased ri…
View article: Recent Trends in Research on the Polygraph Tests
Recent Trends in Research on the Polygraph Tests Open
過去10年間に,隠匿情報検査(Concealed information test, CIT)と呼ばれる情報検出技術について,幾つかの重要な進歩が見られた。本稿では,2010年以降に見られた自律系CITに関する概念的・理論的・技術的進展について概観する。CITの理論的説明については,従来の定位反応説を発展させたものとして反応分離アプローチが提唱された。CITの妥当性に関しては,伝統的な皮膚伝導度反応測度以外の複数指標について確証された。また,幾つかの研究は,生理的信号の測定…
View article: COVID-19 transmission in dental and oral/maxillofacial surgical practice during pandemic: questionnaire survey in 51 university hospitals in Japan
COVID-19 transmission in dental and oral/maxillofacial surgical practice during pandemic: questionnaire survey in 51 university hospitals in Japan Open
COVID-19 clusters are unlikely to occur in dental and oral surgical care settings if appropriate protective measures are implemented.
View article: MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression
MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression Open
MicroRNA-152 (miR-152) expression has been reported to be associated with poor prognosis in patients with endometrial serous carcinoma (ESC). However, the function of miR-152 in ESCs is not fully understood. The present study aimed to inve…
View article: CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents Open
Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase complex, which functions as a chromati…
View article: Within-questionnaire consistency of the differential physiological responses in a Concealed Information Test: hierarchical Bayesian approach
Within-questionnaire consistency of the differential physiological responses in a Concealed Information Test: hierarchical Bayesian approach Open
The concealed information test (CIT) is a psychophysiological memory-detection technique. The judgment to assess whether an examinee recognizes crime-relevant information is based on the difference in autonomic responses between the crime-…
View article: The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy
The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy Open
The impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. The aim of this retrospective analysis was to assess clinicopathological findings and clinical outcome by histo…
View article: Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer
Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer Open
Inhibitor of apoptosis (IAP) proteins are frequently upregulated in ovarian cancer, resulting in the evasion of apoptosis and enhanced cellular survival. Birinapant, a synthetic second mitochondrial activator of caspases (SMAC) mimetic, su…
View article: Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: Insights from simultaneous familial Kawasaki Disease cases
Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: Insights from simultaneous familial Kawasaki Disease cases Open
Recently, an increasing number of SARS-CoV-2 patients with COVID-19 syndrome, which overlaps with Kawasaki Disease (KD), have been reported, supporting the suggestion that infection is one of the triggers of KD. We summarized the reports o…
View article: IAU volume 15 issue 341 Cover and Front matter
IAU volume 15 issue 341 Cover and Front matter Open
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