Yoichi Tagami
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View article: Familial fibrotic hypersensitivity pneumonitis: A distinct clinical phenotype with shorter leukocyte telomere length
Familial fibrotic hypersensitivity pneumonitis: A distinct clinical phenotype with shorter leukocyte telomere length Open
Familial fibrotic HP may represent a distinct clinical phenotype characterized by shorter telomeres, with LTL emerging as a potential biomarker for disease severity.
View article: Oral Antifibrotic Agents for the Treatment of Progressive Pulmonary Fibrosis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Oral Antifibrotic Agents for the Treatment of Progressive Pulmonary Fibrosis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Open
Introduction: Progressive pulmonary fibrosis (PPF) is a form of interstitial lung disease characterized by irreversible fibrotic progression and deteriorating lung function. Although antifibrotic agents approved for idiopathic pulmonary fi…
View article: Second acute exacerbation of fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis
Second acute exacerbation of fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis Open
Unlike the first AE, no significant difference in the second AE incidence was observed between fibrotic HP and IPF groups. Additionally, KL-6 levels measured 4 weeks after the first AE were identified as a risk factor for the second AE in …
View article: Clinical study of 20 cases of refractory Mycobacterium avium complex pulmonary disease treated with amikacin liposomal inhalation suspension
Clinical study of 20 cases of refractory Mycobacterium avium complex pulmonary disease treated with amikacin liposomal inhalation suspension Open
Backgrounds: Several guidelines have recently indicated amikacin liposome inhalation suspension (ALIS) as a new treatment option for refractory Mycobacterium avium complex pulmonary disease (MAC-PD). There are a few reports on the efficacy…
View article: Transbronchial Mediastinal Cryobiopsy in Diagnosing Sarcoidosis: A Three-Case Report
Transbronchial Mediastinal Cryobiopsy in Diagnosing Sarcoidosis: A Three-Case Report Open
Recent reports suggest that a transbronchial mediastinal cryobiopsy (TMC) offers a better diagnostic performance for benign diseases than endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) because it can obtain la…
View article: ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases
ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases Open
View article: Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease
Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease Open
View article: Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease
Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease Open
Serum heme oxygenase (HO)-1 level has been reported as a clinically reliable diagnostic biomarker for acute exacerbation (AE) of interstitial lung disease (ILD); however, its utility for predicting mortality among these patients is unclear…
View article: The clinical impact of comorbidities among patients with idiopathic pulmonary fibrosis undergoing anti-fibrotic treatment: A multicenter retrospective observational study
The clinical impact of comorbidities among patients with idiopathic pulmonary fibrosis undergoing anti-fibrotic treatment: A multicenter retrospective observational study Open
Background Among patients with idiopathic pulmonary fibrosis (IPF), few studies have investigated the clinical impact of anti-fibrotic treatment (AFT) with and without comorbidities. The aim of the study was to determine whether Charlson C…
View article: ＜Editors' Choice＞ Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia.
＜Editors' Choice＞ Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia. Open
Acute exacerbation (AE) of interstitial pneumonia (IP) shows poor prognosis, due to the typical histological pattern of diffuse alveolar damage superimposed upon lung fibrosis. The previous reports comparing clinical features between AE of…
View article: ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease
ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease Open
Background. The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD…
View article: Adverse events induced by durvalumab and tremelimumab combination regimens: a systematic review and meta-analysis
Adverse events induced by durvalumab and tremelimumab combination regimens: a systematic review and meta-analysis Open
Background: Immune checkpoint inhibitors (ICIs) have shown remarkable therapeutic outcomes among cancer patients. Durvalumab plus tremelimumab (DT) is under investigation as a new ICI combination therapy, and its efficacy has been reported…
View article: Assessment of diagnostic utility of serum hemeoxygenase-1 measurement for acute exacerbation of interstitial pneumonias
Assessment of diagnostic utility of serum hemeoxygenase-1 measurement for acute exacerbation of interstitial pneumonias Open
The present study aimed to evaluate whether serum heme oxygenase (HO)-1 could be a reliable blood biomarker for diagnosing acute exacerbations (AEs) of both idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia (SIP)…
View article: ILD-GAP combined with the Charlson Comorbidity Index score (ILD-GAPC) as a prognostic prediction model in patients with idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, and collagen vascular disease-related interstitial pneumonia
ILD-GAP combined with the Charlson Comorbidity Index score (ILD-GAPC) as a prognostic prediction model in patients with idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, and collagen vascular disease-related interstitial pneumonia Open
Background The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-…
View article: Adverse events induced by nivolumab and ipilimumab combination regimens
Adverse events induced by nivolumab and ipilimumab combination regimens Open
Background: No meta-analysis has assessed the pooled frequencies of adverse events (AEs) induced by concomitant nivolumab plus ipilimumab regimen for anticancer-medications-naïve malignancies. Furthermore, no meta-analysis has compared det…
View article: Clinical importance of serum heme oxygenase-1 measurement in patients with acute exacerbation of idiopathic pulmonary fibrosis triggered by coronavirus disease 2019
Clinical importance of serum heme oxygenase-1 measurement in patients with acute exacerbation of idiopathic pulmonary fibrosis triggered by coronavirus disease 2019 Open
View article: Multiple respiratory complications in a patient with Charcot-Marie-Tooth disease with MFN2 mutation
Multiple respiratory complications in a patient with Charcot-Marie-Tooth disease with MFN2 mutation Open
View article: Pembrolizumab monotherapy versus pembrolizumab plus chemotherapy in patients with non‐small‐cell lung cancer: A multicenter retrospective trial
Pembrolizumab monotherapy versus pembrolizumab plus chemotherapy in patients with non‐small‐cell lung cancer: A multicenter retrospective trial Open
Background Pembrolizumab alone or in combination with chemotherapy is a standard treatment for patients with non‐small‐cell lung cancer (NSCLC) with high programmed death‐ligand 1 (PD‐L1) expression. However, no study has compared the effi…
View article: Comparison of Clinical Features between the High and Low Serum KL-6 Patients with Acute Exacerbation of Interstitial Lung Diseases
Comparison of Clinical Features between the High and Low Serum KL-6 Patients with Acute Exacerbation of Interstitial Lung Diseases Open
Background. Serum Krebs von den Lungen-6 (KL-6) measurement is widely used to assess disease activity or prognosis in patients with interstitial lung diseases (ILDs). However, the clinical differences between high and low serum KL-6 levels…
View article: Best regimens for treating chemo‐naïve incurable squamous non‐small cell lung cancer with a programmed death‐ligand 1 tumor proportion score of 1%–49%: A network meta‐analysis
Best regimens for treating chemo‐naïve incurable squamous non‐small cell lung cancer with a programmed death‐ligand 1 tumor proportion score of 1%–49%: A network meta‐analysis Open
Background Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related mortality worldwide. It is advisable to select the appropriate treatment based on characteristics of the cancer such as pathology, mutations, and programm…
View article: The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease
The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease Open
Background. The purpose of this retrospective study was to clarify whether the presence of honeycombing on computed tomography (CT) can affect the prognosis of patients with acute exacerbations (AEs) of interstitial lung diseases (ILDs). M…
View article: P8‐55: A review of cases of gene panel testing using next‐generation sequencers at our hospital
P8‐55: A review of cases of gene panel testing using next‐generation sequencers at our hospital Open
therefore probable candidates for ICIs.
View article: P8‐54: Is combination chemotherapy with ICI and cytotoxic agents always better than monotherapy with ICI in patients with advanced NSCLC?
P8‐54: Is combination chemotherapy with ICI and cytotoxic agents always better than monotherapy with ICI in patients with advanced NSCLC? Open
therefore probable candidates for ICIs.
View article: P16‐27: A deep learning approach using chest X‐ray data for screening drug‐induced interstitial lung disease
P16‐27: A deep learning approach using chest X‐ray data for screening drug‐induced interstitial lung disease Open
exacerbations (p = 0.039).Furthermore, patients with sarcopenia demonstrated a significantly shorter median OS compared to those without the same (9.2 vs. 13.3 months; p = 0.029).Conclusions: Sarcopenia predicted chemotherapy-triggered ILD…
View article: P8‐154: Pulmonary epithelioid hemangioendothelioma in adult young man
P8‐154: Pulmonary epithelioid hemangioendothelioma in adult young man Open
Background and Aims: Bronchoscopic techniques like endobronchial ultrasound (EBUS) and EUS-B (endoscopic ultrasound with bronchoscope) has a key role in diagnosing and or staging mediastinal and central lesions of the lung.EBUS is still in…
View article: P8‐69: Clinical study of chemotherapy with an immune checkpoint inhibitor combination chemotherapy in advanced small cell lung cancer
P8‐69: Clinical study of chemotherapy with an immune checkpoint inhibitor combination chemotherapy in advanced small cell lung cancer Open
occurred in 23patients, including two cases of pneumonitis.No grade 3 or higher adverse event was observed.Conclusion: Atezolizumab showed promising anti-tumor activity regardless of PD-L1 expression status with a manageable safety profile…
View article: P8‐67: A retrospective study of recurrence patterns in chemoradiotherapy using volumetric modulated arc therapy for locally advanced non‐small cell lung cancer
P8‐67: A retrospective study of recurrence patterns in chemoradiotherapy using volumetric modulated arc therapy for locally advanced non‐small cell lung cancer Open
occurred in 23patients, including two cases of pneumonitis.No grade 3 or higher adverse event was observed.Conclusion: Atezolizumab showed promising anti-tumor activity regardless of PD-L1 expression status with a manageable safety profile…
View article: Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study
Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study Open
Lung lesions of Hodgkin's lymphoma (HL) are rare and difficult to diagnose by nonsurgical biopsy. We herein present the case of a 72‐year‐old Japanese male who presented with accumulation of lung infiltrates and masses bilaterally on the l…
View article: I. Diagnosis and Pharmacotherapy for Cough and Sputum
I. Diagnosis and Pharmacotherapy for Cough and Sputum Open
[in Japanese]
View article: Clinical subtyping for patients with acute exacerbations of interstitial lung diseases guided by serum KL-6 measurement
Clinical subtyping for patients with acute exacerbations of interstitial lung diseases guided by serum KL-6 measurement Open
Introduction: Serum Krebs von den Lungen-6 (KL-6) measurement is widely used to assess disease activity or prognosis in patients with interstitial lung diseases (ILDs). However, the clinical differences between high and low serum KL-6 leve…