Woong‐Yang Park
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View article: The role of APOBEC in early-stage epidermal growth factor receptor-mutant non-small cell lung cancer
The role of APOBEC in early-stage epidermal growth factor receptor-mutant non-small cell lung cancer Open
APOBEC enrichment may present at initial diagnosis of early-stage EGFR mutant NSCLC and is associated with poor post-recurrence TKI PFS and PRS rather than RFS.
View article: P02.08.A A SPATIALLY RESOLVED HUMAN GLIOBLASTOMA ATLAS REVEALS DISTINCT CELLULAR AND MOLECULAR PATTERNS OF ANATOMICAL NICHES
P02.08.A A SPATIALLY RESOLVED HUMAN GLIOBLASTOMA ATLAS REVEALS DISTINCT CELLULAR AND MOLECULAR PATTERNS OF ANATOMICAL NICHES Open
BACKGROUND Glioblastoma (GBM) is the most lethal brain tumor in adults with remarkable cellular plasticity and complex anatomical features. While single-cell RNA sequencing (scRNA-seq) has revealed its cellular heterogeneity, the spatial c…
View article: Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix
Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix Open
Background Cancer metastasis, primarily driven by epithelial-to-mesenchymal transition (EMT), is responsible for most cancer-related mortalities. Traditional pre-clinical models fail to fully capture mesenchymal characteristics due to the …
View article: STRUMP-I: Structure-based machine learning approach to pMHC-I binding prediction using force field energy features
STRUMP-I: Structure-based machine learning approach to pMHC-I binding prediction using force field energy features Open
The adaptive immune system monitors cellular integrity by recognizing short peptides from intracellular proteins presented on Major Histocompatibility Complex class I (MHC-I) molecules, collectively termed peptide-MHC complexes (pMHC), ena…
View article: Identification of GREM-1 and GAS6 as Specific Biomarkers for Cancer-Associated Fibroblasts Derived from Patients with Non-Small-Cell Lung Cancer
Identification of GREM-1 and GAS6 as Specific Biomarkers for Cancer-Associated Fibroblasts Derived from Patients with Non-Small-Cell Lung Cancer Open
Background/Objectives: Cancer-associated fibroblasts (CAFs) play a pivotal role in the tumor microenvironment. We conducted an analysis using RNA sequencing to identify specific markers for CAFs compared to normal fibroblasts (NFs) in non-…
View article: ACE inhibition increases Alzheimer's disease risk by promoting tau phosphorylation
ACE inhibition increases Alzheimer's disease risk by promoting tau phosphorylation Open
Reportedly, over 60% of individuals in the USA aged 65 or older take antihypertensive medications, making it crucial to evaluate their potential impact on dementia. Alzheimers disease (AD), the most prevalent form of dementia, develops ins…
View article: Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritis
Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritis Open
The fluctuating nature of disease activity in systemic lupus erythematosus (SLE), alternating between flares and remissions, poses substantial challenges for its effective management. The use of current biomarkers for monitoring SLE is lim…
View article: Determinant of Aggressive Phenotype in Metastatic Hormone-Sensitive Prostate Cancer Depends on an Intrinsic, Highly Aggressive Cell Cluster: Integrated Single-Cell RNA and Whole Transcriptomic Sequencing Analyses
Determinant of Aggressive Phenotype in Metastatic Hormone-Sensitive Prostate Cancer Depends on an Intrinsic, Highly Aggressive Cell Cluster: Integrated Single-Cell RNA and Whole Transcriptomic Sequencing Analyses Open
Purpose: Although the combination of androgen deprivation therapy with docetaxel or abiraterone acetate and prednisone has become a standard treatment for metastatic hormone-sensitive prostate cancer (mHSPC) and has shown improved overall …
View article: Effects of tcVNS and Multimodal Stimulation on Heart Rate Variability and Stress Regulation
Effects of tcVNS and Multimodal Stimulation on Heart Rate Variability and Stress Regulation Open
Background Transcutaneous cervical vagus nerve stimulation (tcVNS) is a non-invasive neuromodulation that can influence autonomic function and emotional regulation by activating vagal pathways. Similarly, slow breathing exercises and aroma…
View article: HISSTA: a human in situ single-cell transcriptome atlas
HISSTA: a human in situ single-cell transcriptome atlas Open
Motivation Spatial transcriptomics holds great promise for revolutionizing biology and medicine by providing gene expression profiles with spatial information. Until recently, spatial resolution has been limited, but advances in high-throu…
View article: Asian diversity in human immune cells
Asian diversity in human immune cells Open
The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell R…
View article: Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma
Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma Open
Background Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)–based therapy, improving outcomes but with variable individual responses. This st…
View article: Precision Oncology: A Global Perspective on Implementation and Policy Development
Precision Oncology: A Global Perspective on Implementation and Policy Development Open
Despite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full potential for advancing care and prevention remains unrealized. The benefits are currently accessible to only limited patient seg…
View article: Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases
Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases Open
Alternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicin…
View article: Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden
Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden Open
Clonal hematopoiesis of indeterminate potential (CHIP) allows estimation of clonal dynamics and documentation of somatic mutations in the hematopoietic system. Recent studies utilizing large cohorts of the general population and patients h…
View article: Supplementary Figure 4 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Supplementary Figure 4 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine Open
Concept of no-placebo initiative
View article: Supplementary Table 1 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Supplementary Table 1 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine Open
List of regulatory approvals for targeted therapies and associated clinical trials in SCRUM-Japan MONSTAR-SCREEN project
View article: Supplementary Table 2 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Supplementary Table 2 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine Open
List of regulatory approvals for companion diagnostic therapeutics in SCRUM-Japan MONSTAR-SCREEN project
View article: Supplementary Table 3 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Supplementary Table 3 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine Open
Cox multivariate analysis of overall survival
View article: Supplementary Table 4 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Supplementary Table 4 from The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine Open
Summary of umbrella and basket trials evaluating the efficacy of targeted biomarker-driven therapies