Yu Sun
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View article: Ultrasoft hydrogel immune millirobot with multimodal locomotion
Ultrasoft hydrogel immune millirobot with multimodal locomotion Open
Advancements in cellular immunotherapy demanded efficient immune cell delivery. To meet this need, we introduced hydrogel-based immune millirobots designed for high immune cell loading and precise tumor targeting. These ultrasoft robots, e…
View article: Task-specific effects of sleep deprivation on cognitive function and EEG brain network in night-shift nurses
Task-specific effects of sleep deprivation on cognitive function and EEG brain network in night-shift nurses Open
In conclusion, these results demonstrate that sleep deprivation elicits task-specific neurocognitive adaptations. Sustained attention appears highly vulnerable, prompting a broad compensatory reorganization of the right-hemispheric attenti…
View article: DTI-Based Structural Connectome Analysis of SCLC Patients After Chemotherapy via Machine Learning
DTI-Based Structural Connectome Analysis of SCLC Patients After Chemotherapy via Machine Learning Open
Small-cell lung cancer (SCLC) is an aggressive malignancy that exhibits high prevalence for brain metastases. Furthermore, chemotherapy and metastasis-preventive approaches are also linked to neurotoxicity, further aggravating cognitive im…
View article: Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone
Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone Open
Bone metastasis causes severe complications for patients suffering from advanced‐stage prostate cancer. Exercise is recommended to help maintain musculoskeletal health during treatment. As primary mechanosensors and regulators of bone home…
View article: Primary ovarian CIC-rearranged sarcoma in a child: a rare case report and review of the literature
Primary ovarian CIC-rearranged sarcoma in a child: a rare case report and review of the literature Open
Introduction CIC-rearranged sarcoma (CRS) is a rare type of high-grade undifferentiated small round cell sarcoma characterized by a range of possible CIC gene rearrangements. It develops predominantly in the deep soft tissues of the limbs …
View article: Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis
Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis Open
Radiotherapy is a cornerstone of breast cancer treatment, but it can unintentionally damage bone, causing bone loss and pain, with no currently effective therapeutic strategy available. While chemically mediated radioprotection is extensiv…
View article: Inverse obstacle scattering with a single moving emitter
Inverse obstacle scattering with a single moving emitter Open
This paper is concerned with time domain forward scattering and inverse scattering problems with a single moving point source as the emitter. Approximate solutions are provided for the forward scattering problem with a moving emitter. Rega…
View article: Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation
Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation Open
Cells transmit extracellular physical signals across the membrane into the nucleus through membrane mechanoreceptors (such as integrins, mechanically gated ion channels) and the cytoskeletal network. This process leads to redistribution of…
View article: Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies
Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies Open
This article describes the isolation, culture, and integration of primary murine osteocytes on a microfluidic platform for in vitro mechanobiology studies. Osteocytes are mechanosensitive cells embedded within the bone matrix and regulate …
View article: A thermodynamic perspective on mammalian neural crest ingression
A thermodynamic perspective on mammalian neural crest ingression Open
The ingression of neural crest cells from an ectodermal to a mesodermal layer is regulated by instructive, directional cues and potentially stochastic, biophysical parameters such as differential cell adhesion and tension heterogeneity. Ho…
View article: Combined effect of body mass index and atherogenic index of plasma on risk of stroke among individuals with abnormal glucose metabolism: Evidence from the China health and retirement longitudinal study
Combined effect of body mass index and atherogenic index of plasma on risk of stroke among individuals with abnormal glucose metabolism: Evidence from the China health and retirement longitudinal study Open
Objective We aimed to explored the association between atherogenic index of plasma (AIP), body mass index (BMI) and stroke risk among people with abnormal glucose metabolism. Methods This study included participants with abnormal glucose m…
View article: Arithmetic properties for sparse sequence of integers and its application in number theory, additive combinatorics and ergodic theory
Arithmetic properties for sparse sequence of integers and its application in number theory, additive combinatorics and ergodic theory Open
Arithmetic properties for sparse sequence of integers and its application in number theory, additive combinatorics and ergodic theory In this project we investigate dynamical and form {⌊𝑛𝑐⌋}, for 1<c<2 as large as possible, arithmetic stat…
View article: Molecular stratification of prostate cancer through sensory perception-related multi-omics analysis reveals chemoresistant mechanisms
Molecular stratification of prostate cancer through sensory perception-related multi-omics analysis reveals chemoresistant mechanisms Open
This study establishes sensory perception-associated molecular subtypes in PCa and links CS1 chemoresistance to immune microenvironment reprogramming via TNF-CCL20 signaling. These findings offer mechanistic insights into PCa progression a…
View article: Robotic Needle Steering for Percutaneous Interventions: Sensing, Modeling, and Control
Robotic Needle Steering for Percutaneous Interventions: Sensing, Modeling, and Control Open
Robotic needle steering plays a critical role in improving the precision and safety of percutaneous interventions across various clinical applications. However, manual needle steering remains challenged by operator‐dependent variability, p…
View article: Multimodal brain network analysis reveals divergent dysconnectivity patterns during mental fatigue: A concurrent EEG-fMRI study
Multimodal brain network analysis reveals divergent dysconnectivity patterns during mental fatigue: A concurrent EEG-fMRI study Open
For the apparent importance of mental fatigue in neuroergonomics, continuous efforts have been made to reveal the underlying neural mechanisms. Using concurrent EEG-fMRI network analysis, this work aims to reveal fatigue-related brain netw…
View article: Surface Charge Affects the Intracellular Fate and Clearance Dynamics of CdSe/ZnS Quantum Dots in Macrophages
Surface Charge Affects the Intracellular Fate and Clearance Dynamics of CdSe/ZnS Quantum Dots in Macrophages Open
The biological effects of nanoparticles are closely related to their intracellular content and location, both of which are influenced by various factors. This study investigates the effects of surface charge on the uptake, intracellular di…
View article: An electrocyte‐inspired moisture‐driven electricity generator for self‐sustained water electrolysis
An electrocyte‐inspired moisture‐driven electricity generator for self‐sustained water electrolysis Open
Harvesting electricity from ubiquitous moisture offers the promise of clean power for self‐sustained systems. Despite extensive efforts, achieving high‐power electricity generation remains challenging. Existing studies mimicking electric e…
View article: Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics
Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics Open
Background Lactate-driven metabolic reprogramming and histone lactylation play pivotal roles in bladder cancer (BLCA) progression, yet their underlying mechanisms and regulatory genes remain poorly understood. Methods Using transcriptomic …
View article: Reference equations for pulmonary function testing in healthy Chinese children aged 4–18 years
Reference equations for pulmonary function testing in healthy Chinese children aged 4–18 years Open
NO.: ChiCTR: 1,800,019,029. Registered 22 October 2018.
View article: Blastocyst selection through an interpretable artificial intelligence method versus traditional morphology grading: study protocol for a randomised controlled trial
Blastocyst selection through an interpretable artificial intelligence method versus traditional morphology grading: study protocol for a randomised controlled trial Open
Introduction The quality of the blastocyst (day 5/6 embryo) selected for transfer is critical for the success of in vitro fertilisation (IVF) treatment. Embryologists perform blastocyst evaluation by observing the morphology of each blasto…
View article: Liquid lens-based endoscopic OCT probe with adjustable focus for 3D imaging in cross-sectionally irregular lumens
Liquid lens-based endoscopic OCT probe with adjustable focus for 3D imaging in cross-sectionally irregular lumens Open
For imaging and inspecting lumens in industrial components, endoscopic optical coherence tomography (OCT), with its high resolution and compact probe, is a promising method. The majority of OCT probes possess a fixed depth of field (DOF) a…
View article: Technology Roadmap of Micro/Nanorobots
Technology Roadmap of Micro/Nanorobots Open
Inspired by Richard Feynman's 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite t…
View article: Research on the Factors Influencing Broken-Bridge Aluminum Exterior Windows with the Goal of Thermal Performance Improvement
Research on the Factors Influencing Broken-Bridge Aluminum Exterior Windows with the Goal of Thermal Performance Improvement Open
The enhancement of the thermal performance of transparent envelopes has been demonstrated to be an effective measure for reducing building energy consumption. To achieve enhanced performance in the domain of building windows, considerable …
View article: Super-Resolution Optical Coherence Tomography Using Diffusion Model-Based Plug-and-Play Priors
Super-Resolution Optical Coherence Tomography Using Diffusion Model-Based Plug-and-Play Priors Open
We propose an OCT super-resolution framework based on a plug-and-play diffusion model (PnP-DM) to reconstruct high-quality images from sparse measurements (OCT B-mode corneal images). Our method formulates reconstruction as an inverse prob…
View article: Research on the Frequency Stability Analysis of Grid-Connected Double-Fed Induction Generator Systems
Research on the Frequency Stability Analysis of Grid-Connected Double-Fed Induction Generator Systems Open
Existing approaches insufficiently analyze the quantitative relationship between frequency stability indices and wind power penetration rates. This limitation impedes rapid and accurate assessments of wind power’s grid integration potentia…