Yaqin Chai
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View article: Dynamic Handwriting Features for Cognitive Assessment in Inflammatory Demyelinating Diseases: A Machine Learning Study
Dynamic Handwriting Features for Cognitive Assessment in Inflammatory Demyelinating Diseases: A Machine Learning Study Open
Cognitive impairment is common but often overlooked in patients with inflammatory demyelinating diseases such as multiple sclerosis and neuromyelitis optica spectrum disorder. The conventional assessments may fail to detect subtle deficits…
View article: Reading Recognition in the Wild
Reading Recognition in the Wild Open
To enable egocentric contextual AI in always-on smart glasses, it is crucial to be able to keep a record of the user's interactions with the world, including during reading. In this paper, we introduce a new task of reading recognition to …
View article: A Programmed DNA Dynamic Assembly‐Guided Molecular Amplifier for Authentic Information Decryption
A Programmed DNA Dynamic Assembly‐Guided Molecular Amplifier for Authentic Information Decryption Open
Nucleic acid‐based cryptographic approaches are an innovative emerging field for information process. However, the poor reproducibility and interference from bioenvironment of the existing decryption led to different binary translation acc…
View article: Decoding the Moving Mind: Multi-Subject fMRI-to-Video Retrieval with MLLM Semantic Grounding
Decoding the Moving Mind: Multi-Subject fMRI-to-Video Retrieval with MLLM Semantic Grounding Open
Decoding dynamic visual information from brain activity remains challenging due to inter-subject neural heterogeneity, limited per-subject data availability, and the substantial temporal resolution gap between fMRI signals (0.5 Hz) and vid…
View article: Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress
Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress Open
Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-2…
View article: Difference in mortality risk predicted by leukocyte and lymphocyte levels in COVID-19 patients infected with the Wild-type, Delta, and Omicron strains
Difference in mortality risk predicted by leukocyte and lymphocyte levels in COVID-19 patients infected with the Wild-type, Delta, and Omicron strains Open
This study aimed to investigate the changing trends, level differences, and prognostic performance of the leukocyte and lymphocyte levels of patients infected with the Wild strains, Delta strains and Omicron strains to provide a reference …
View article: Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence
Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence Open
We report for the first time the phenomenon of continuously color-tunable ECL from individual Au NCs confined in a porous hydrogel matrix. The color-tunable ECL property arises from the dynamic surface reconstruction of Au NCs and co-react…
View article: Dual-layer 3D DNA nanostructure: The next generation of ultrafast DNA nanomachine for microRNA sensing and intracellular imaging
Dual-layer 3D DNA nanostructure: The next generation of ultrafast DNA nanomachine for microRNA sensing and intracellular imaging Open
The working efficiency of traditional 3D DNA nanomachines is extremely restricted due to the complex DNA components modified on nanoparticles in the same spatial height. Herein, an ultrafast dual-layer 3D DNA nanomachine (UDDNM) based on c…
View article: Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells
Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells Open
We designed two functionalized tetrahedral DNA nanostructures (f-TDN1 and f-TDN2), which could assemble into giant DNA networks triggered by APE1, achieving sensitive detection and intracellular imaging of APE1 as well as gene therapy.
View article: Programmable mismatch-fueled high-efficiency DNA signal amplifier
Programmable mismatch-fueled high-efficiency DNA signal amplifier Open
We proposed an ingenious mismatch-enhanced catalytic multiple-arm DNA junction assembly (M-CMDJA) which possesses more negative reaction standard free energy (Δ G ) as the driving force, resulting in quite high conversion efficiency and mu…
View article: Programmable High‐Speed and Hyper‐Efficiency DNA Signal Magnifier
Programmable High‐Speed and Hyper‐Efficiency DNA Signal Magnifier Open
Herein, a programmable dual‐catalyst hairpin assembly (DCHA) for realizing the synchronous recycle of two catalysts is developed, displaying high reaction rate and outstanding conversion efficiency beyond traditional nucleic acid signal am…
View article: A core–brush 3D DNA nanostructure: the next generation of DNA nanomachine for ultrasensitive sensing and imaging of intracellular microRNA with rapid kinetics
A core–brush 3D DNA nanostructure: the next generation of DNA nanomachine for ultrasensitive sensing and imaging of intracellular microRNA with rapid kinetics Open
This study designed a highly loaded and integrated core–brush 3D DNA nanomachine for miRNA imaging and sensing, which easily solves the major technical challenges of traditional Au-based 3D nanomachines: low loading capacity and low execut…
View article: A DNA nanopillar as a scaffold to regulate the ratio and distance of mimic enzymes for an efficient cascade catalytic platform
A DNA nanopillar as a scaffold to regulate the ratio and distance of mimic enzymes for an efficient cascade catalytic platform Open
A rigid 3D DNA nanopillar was used to investigate the influence of spatial organization on the cascade activity in multienzyme systems, realizing controllable regulation of the mimic enzyme ratio and spacing for efficient cascade catalytic…