Yafei Li
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View article: GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation Open
Hepatitis E virus (HEV) is a viral hepatitis pathogen that poses a significant threat to global human health, representing a serious yet long-overlooked public health concern. In this study, we identified glucose-regulated protein 75 (GRP7…
View article: Transition of pseudorabies virus from latency to reactivation state selectively triggered by pathogenic bacteria
Transition of pseudorabies virus from latency to reactivation state selectively triggered by pathogenic bacteria Open
Pseudorabies virus (PRV) causes severe morbidity and mortality in pigs and must be eradicated from pig populations. The increasing PRV infections in humans—resulting in severe encephalitis, neurological sequelae, and death since 2017 in Ch…
View article: Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis
Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis Open
Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight hepari…
View article: Characterization of fosS, a novel fosfomycin-modifying enzyme gene identified in Staphylococcus haemolyticus
Characterization of fosS, a novel fosfomycin-modifying enzyme gene identified in Staphylococcus haemolyticus Open
The efficacy of fosfomycin is increasingly challenged by emerging resistance mechanisms, primarily involving fosfomycin-modifying enzymes and target (MurA) alterations. This study aimed to elucidate the novel mechanism underlying fosfomyci…
View article: Latent profile analysis of college students’ healthy lifestyles and its association with physical activity
Latent profile analysis of college students’ healthy lifestyles and its association with physical activity Open
Objective This study investigates the latent profiles of healthy lifestyles among college students and examines their associations with physical activity levels, thereby establishing a scientific foundation for developing targeted interven…
View article: Circular RNA hsa_circ_0000118 promotes atrial fibrosis by regulating the microRNA‑34a‑5p/Smad4 axis
Circular RNA hsa_circ_0000118 promotes atrial fibrosis by regulating the microRNA‑34a‑5p/Smad4 axis Open
The regulatory functions and underlying mechanisms of circular RNAs (circRNAs/circs) in atrial fibrillation (AF) are largely unknown. The present study aimed to assess the prognostic roles and potential biological functions of hsa_circ_000…
View article: Figure S8 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S8 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
Tumor volume of AAV-SFTA1P and AAV-NC treatment group
View article: Figure S3 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S3 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The gene expression correlations between SFTA1P and downstream target genes of TGF-β signaling pathway.
View article: Data from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Data from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
SFTA1P is a pseudogene-derived long noncoding RNA and has become a master regulator in tumor carcinogenesis and progression processes. SFTA1P has been reported as a potential diagnostic and prognostic biomarker in non–small cell lung cance…
View article: Table S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Table S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
Primers and RNA oligonucleotides sequences used in this study.
View article: Figure S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The expression patterns and subcellular localization of SFTA1P in lung cancer cell lines.
View article: Figure S2 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S2 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
Effects of SFTA1P on lung squamous cell carcinoma cell proliferation, apoptosis, and migration in vitro
View article: Figure S7 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S7 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The expression of YTHDC1 level in shNC and shYTHDC1 in A549 and H1299 cells, detected by qRT-PCR and western blotting.
View article: Figure S5 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S5 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The protein expression of E-cadherin and Vimentin were evaluated by WB in H1299 cells after treated with siRNA targeting SFTA1P and BAY-1143572 (1μM).
View article: Figure S6 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S6 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The m6A RNA modification sites in SFTA1P sequence identified by using SRAMP prediction server (http://www.cuilab.cn/sramp)
View article: Figure S4 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb
Figure S4 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb Open
The relationship of TGFBR2, PI3K−Akt signaling pathway protein expression levels and SFTA1P
View article: Unraveling the Compound Eye Design of the Diurnal Moth Histia flabellicornis (Lepidoptera: Zygaenidae)
Unraveling the Compound Eye Design of the Diurnal Moth Histia flabellicornis (Lepidoptera: Zygaenidae) Open
Lepidoptera typically exhibit a dichotomy in compound eye design: diurnal butterflies possess apposition eyes for high resolution in bright light, whereas nocturnal moths have superposition eyes for enhanced sensitivity under dim condition…
View article: Identification of differentially expressed genes and proteins related to diapause in Lymantria dispar: Insights for the mechanism of diapause from transcriptome and proteome analyses
Identification of differentially expressed genes and proteins related to diapause in Lymantria dispar: Insights for the mechanism of diapause from transcriptome and proteome analyses Open
Spongy moth ( Lymantria dispar Linnaeus) is a globally recognized quarantine leaf-eating pest. Spongy moths typically enter diapause after completing embryonic development and overwinter in the egg stage. They spend three-quarters of their…
View article: CNN–Patch–Transformer-Based Temperature Prediction Model for Battery Energy Storage Systems
CNN–Patch–Transformer-Based Temperature Prediction Model for Battery Energy Storage Systems Open
Accurate predictions of the temperature of battery energy storage systems (BESSs) are crucial for ensuring their efficient and safe operation. Effectively addressing both the long-term historical periodic features embedded within long look…
View article: Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH
Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH Open
Background and Objectives: Identifying carriers of Pathogenic/Likely Pathogenic Variants in patients with dementia is crucial for risk stratification, particularly in individuals with a family history. This study developed and validated a …
View article: Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment
Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment Open
Tumor microenvironment (TME) refers to the local environment in which various cancer cells grow, encompassing tumor cells, adjacent non-tumor cells, and associated non-cellular elements, all of which collectively promote cancer occurrence …
View article: Gradient-Guided Credit Assignment and Joint Optimization for Dependency-Aware Spatial Crowdsourcing
Gradient-Guided Credit Assignment and Joint Optimization for Dependency-Aware Spatial Crowdsourcing Open
Dependency-aware spatial crowdsourcing (DASC) addresses the unique challenges posed by subtask dependencies in spatial task assignment. This paper investigates the task assignment problem in DASC and proposes a two-stage Recommend and Matc…
View article: The type of pathogen is associated with organ failure and legacy dysfunction in patients with sepsis
The type of pathogen is associated with organ failure and legacy dysfunction in patients with sepsis Open
Introduction Is there a difference in pathogen infection among sepsis patients with different organ dysfunction and Post-sepsis persistent organ dysfunction? Is this related to survival? It is currently unclear. Methods This study reviewed…
View article: [Mediating effect of sleep duration between depression symptoms and myopia in middle school students].
[Mediating effect of sleep duration between depression symptoms and myopia in middle school students]. Open
Sleep duration serves as a partial mediator between depression symptoms and myopia in middle school students.
View article: Sleep disturbances among older adults from the Russian Far East experiencing social loss: is there a sex difference?
Sleep disturbances among older adults from the Russian Far East experiencing social loss: is there a sex difference? Open
Our findings emphasize that social loss is a risk factor for sleep disturbances, while social interaction serves as a buffering factor for sleep disturbances in elderly females experiencing social loss. This suggests that providing targete…