Yani Liu
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View article: R-loops and small RNA regulatory interactions: mechanisms and clinical perspectives
R-loops and small RNA regulatory interactions: mechanisms and clinical perspectives Open
An R-loop is a three-stranded nucleic acid structure that serves as a transcriptional intermediate, consisting of an RNA-DNA hybrid and a displaced single-stranded DNA (ssDNA). Small RNAs are RNA molecules shorter than 300 nucleotides that…
View article: Intestinal oxygen and microbiota crosstalk: implications for pathogenesis of gastrointestinal diseases and emerging therapeutic strategies
Intestinal oxygen and microbiota crosstalk: implications for pathogenesis of gastrointestinal diseases and emerging therapeutic strategies Open
The gut microbiota and its hypoxic host environment play a critical role in human health. Despite its importance, the mechanisms maintaining homeostasis and the characteristics defining dysbiosis remain largely undefined. In particular, th…
View article: Improved stroke risk stratification in carotid atherosclerosis: integrating intraplaque neovascularization into Carotid Plaque-RADS
Improved stroke risk stratification in carotid atherosclerosis: integrating intraplaque neovascularization into Carotid Plaque-RADS Open
Integration of the presence of IPN Grade 2 into Carotid Plaque-RADS significantly enhanced its ability for stratifying stroke recurrence risk.
View article: Transapical beating-heart septal myectomy for Fabry cardiomyopathy with left ventricular outflow tract obstruction: a retrospective case series
Transapical beating-heart septal myectomy for Fabry cardiomyopathy with left ventricular outflow tract obstruction: a retrospective case series Open
TA-BSM appears to be a feasible and effective therapeutic option for Fabry cardiomyopathy patients with severe LVOT obstruction refractory to medical therapy. These preliminary findings support the potential role of this novel, minimally i…
View article: An Adaptive BERT-NLP Intelligent Teaching Quality Monitoring Model Integrated with Engineering Supervision Mechanism
An Adaptive BERT-NLP Intelligent Teaching Quality Monitoring Model Integrated with Engineering Supervision Mechanism Open
This study addresses the issues of insufficient real-time performance and poor dynamic adaptability in classroom teaching quality monitoring by proposing an adaptive BERT-NLP intelligent education quality monitoring model integrated with a…
View article: Transapical Beating-Heart Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy With Anomalous Papillary Muscle Insertion
Transapical Beating-Heart Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy With Anomalous Papillary Muscle Insertion Open
Objectives Anomalous papillary muscles (PMs) directly inserted into the anterior mitral valve (MV) constitute an infrequent anomaly in obstructive hypertrophic cardiomyopathy (HCM). This study sought to evaluate the efficacy and safety of …
View article: Substantia Nigra Elasticity Measurement Using Transcranial Shear Wave Elastography: A Potential Biomarker for Parkinson's Disease
Substantia Nigra Elasticity Measurement Using Transcranial Shear Wave Elastography: A Potential Biomarker for Parkinson's Disease Open
Background The diagnosis of Parkinson's disease (PD) lacks reliable biomarkers. This study investigated substantia nigra (SN) elasticity using shear wave elastography (SWE) as a novel diagnostic tool for PD. Objectives To investigate the r…
View article: A novel role of celecoxib in the inhibition of calcium-activated chloride channel ANO1
A novel role of celecoxib in the inhibition of calcium-activated chloride channel ANO1 Open
Celecoxib, a non-steroidal anti-inflammatory drug, is widely used in the clinic for its analgesic and anti-inflammatory effects by inhibiting COX-2. Celecoxib also modulates many ion channels including Nav1.5, Kv7 and Kv2.1 channels. Here …
View article: Effect of tripterine on the pharmacokinetics of cyclosporine A and its mechanism in rats
Effect of tripterine on the pharmacokinetics of cyclosporine A and its mechanism in rats Open
Tripterine is a key active component in Tripterygium wilfordii polyglycosides tablets. Cyclosporine A (CsA) is an immunosuppressive drug that is widely used in organ transplantation. The combined use of Tripterygium wilfordii and CsA can r…
View article: H<sub>2</sub>FPEF and HFA‐PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients
H<sub>2</sub>FPEF and HFA‐PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients Open
Aims H 2 FPEF and HFA‐PEFF scores have demonstrated prognostic value in heart failure (HF) with preserved ejection fraction. This study aimed to explore the value of the H 2 FPEF and HFA‐PEFF scores for HF risk stratification in patients w…
View article: Development and validation of a novel echocardiography-based nomogram for the streamlined classification of cardiac tumors in cancer patients
Development and validation of a novel echocardiography-based nomogram for the streamlined classification of cardiac tumors in cancer patients Open
This study developed a nomogram that involved radiomics and objective indicators based on echocardiography to effectively distinguish between malignant and benign cardiac tumors, thereby improving classification practices and decision-maki…
View article: The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Colorectal Cancer
The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Colorectal Cancer Open
Background: Colorectal cancer (CRC) ranks as the third most common cancer worldwide. Tertiary lymphoid structures (TLSs), organized immune cell aggregates in non-lymphoid tissues, are linked to chronic inflammation and tumorigenesis. Howev…
View article: Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis
Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis Open
The results may provide the rationale for developing GM-based strategies for preventing the onset of RVO.
View article: Systolic anterior motion-mediated mitral regurgitation and surgical management in hypertrophic obstructive cardiomyopathy
Systolic anterior motion-mediated mitral regurgitation and surgical management in hypertrophic obstructive cardiomyopathy Open
Summary Mitral regurgitation mediated by systolic anterior motion is a typical manifestation in patients with hypertrophic obstructive cardiomyopathy. Although septal myectomy is currently the preferred treatment for patients with drug-ref…
View article: How social media exposure constructs social confidence: An empirical study on impact, mechanisms, and multilateral relationships
How social media exposure constructs social confidence: An empirical study on impact, mechanisms, and multilateral relationships Open
Social confidence functions as a vital spiritual force in fostering the positive and healthy evolution of society. This paper explores how social media exposure contributes to the construction of social confidence within the framework of M…
View article: Suboptimal performance of ChatGPT Vision in mitral regurgitation assessment based on color Doppler echocardiography
Suboptimal performance of ChatGPT Vision in mitral regurgitation assessment based on color Doppler echocardiography Open
ChatGPT (OpenAI) has introduced a vision version recently, indicating its potential application in interpreting radiological images. Mitral regurgitation (MR) is the most common valvular heart abnormality, no study has attempted to evaluat…
View article: Early left atrial reverse remodelling in patients with hypertrophic obstructive cardiomyopathy receiving transapical beating-heart septal myectomy
Early left atrial reverse remodelling in patients with hypertrophic obstructive cardiomyopathy receiving transapical beating-heart septal myectomy Open
OBJECTIVES This study aims to investigate the short-term effects of transapical beating-heart septal myectomy (TA-BSM) on left atrial (LA) anatomy and function and its association with clinical indicators in patients with hypertrophic obst…
View article: Diagnostic values of different ultrasonic parameters related to optic nerve sheath for the increased intracranial pressure in patients with brain injury: an observational study
Diagnostic values of different ultrasonic parameters related to optic nerve sheath for the increased intracranial pressure in patients with brain injury: an observational study Open
Background Many studies have suggested that the optic nerve sheath diameter (ONSD) measured by transorbital ultrasound could reflect the increased intracranial pressure (ICP). However, whether the optic nerve subarachnoid space width (ONSA…
View article: Case Report: Mechanical hemolysis resulting from left ventricular outflow tract obstruction after aortic valve replacement relieved by transapical beating-heart septal myectomy
Case Report: Mechanical hemolysis resulting from left ventricular outflow tract obstruction after aortic valve replacement relieved by transapical beating-heart septal myectomy Open
Background Aortic stenosis (AS) in combination with left ventricular outflow tract obstruction (LVOTO) has occasionally been reported. However, making a precise diagnosis and successfully treating this combination is challenging due to the…
View article: Investigation of the differential susceptibility of extraocular muscles in patients diagnosed with ocular myasthenia gravis based on the computerized diplopia test and the Ocular Motor Nerve Palsy Scale
Investigation of the differential susceptibility of extraocular muscles in patients diagnosed with ocular myasthenia gravis based on the computerized diplopia test and the Ocular Motor Nerve Palsy Scale Open
Introduction The pattern of extraocular muscle involvement in ocular myasthenia gravis varies across different reports, diverging from our own observations. Thus, we employed two novel tools to discern this pattern. Methods A retrospective…
View article: A giant left atrial myxoma transits across patent foramen ovale a PFO mimicking biatrial myxoma: a case report
A giant left atrial myxoma transits across patent foramen ovale a PFO mimicking biatrial myxoma: a case report Open
Background Multiple myxomas are rare and often associated with Carney syndrome. We present a giant left atrial myxoma that passes through a patent foramen ovale (PFO), mimicking biatrial myxoma. Case summary A 46-year-old female was admitt…
View article: Improvements of myocardial strain and work in diabetes patients with normal ejection fraction after empagliflozin treatment
Improvements of myocardial strain and work in diabetes patients with normal ejection fraction after empagliflozin treatment Open
Aims/Introduction To assess the effect of empagliflozin treatment on left ventricular (LV), right ventricular (RV) and left atrial (LA) functions in diabetes patients with normal ejection fraction. Materials and Methods The study included …
View article: Relative apical sparing obtained with speckle tracking echocardiography is not a sensitive parameter for diagnosing light-chain cardiac amyloidosis
Relative apical sparing obtained with speckle tracking echocardiography is not a sensitive parameter for diagnosing light-chain cardiac amyloidosis Open
The diagnostic value of relative apical sparing for AL CA was limited with low sensitivity. In clinical practice, the diagnosis of early AL CA patients should not solely rely on relative apical sparing.
View article: Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity
Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity Open
Up to 40% of transplant recipients treated long-term with tacrolimus (TAC) develop post-transplant diabetes mellitus (PTDM). TAC is an important risk factor for PTDM, but is also essential for immunosuppression after transplantation. Long-…