Ya‐Wen Chen
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View article: Alveolar macrophages are early targets of mumps virus 2177
Alveolar macrophages are early targets of mumps virus 2177 Open
Description Mumps virus (MuV) remains active worldwide, despite high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellular targets of MuV in vivo are unknow…
View article: Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids
Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids Open
Retinal ganglion cells (RGCs) are the projection neurons that transmit visual information from the retina to the brain. In many species, a substantial proportion of RGCs are eliminated by programmed cell death during development to regulat…
View article: Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance
Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance Open
Sporoderm-Broken Ganoderma lucidum spore polysaccharides (BGLSPs) have demonstrated therapeutic potential in inflammatory bowel disease (IBD), however, their mechanisms of action in colitis remain unclear. This study aimed to identify the …
View article: Multifunctional liposomes remodeling tumor microenvironment for enhancing Hemoporfin‐mediated photodynamic therapy
Multifunctional liposomes remodeling tumor microenvironment for enhancing Hemoporfin‐mediated photodynamic therapy Open
Photodynamic therapy (PDT) utilizes light and photosensitizer (PS) to generate reactive oxygen species (ROS) to kill cancer cells, presenting a promising strategy as an anti‐cancer treatment. However, the low hydrophilicity and poor target…
View article: Biosynthesis and Regulatory Mechanisms of Fucoxanthin in <em>Isochrysis zhanjiangensis </em>Under Exogenous Glycine Mixotrophic Conditions
Biosynthesis and Regulatory Mechanisms of Fucoxanthin in <em>Isochrysis zhanjiangensis </em>Under Exogenous Glycine Mixotrophic Conditions Open
Glycine is an amino acid that functions as both a carbon and nitrogen source. Glycine mixotrophy enhances microalgal biomass, reduces dependency on light, and optimizes carbon and nitrogen allocation, thereby facilitating the adaptation of…
View article: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer
Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer Open
Background Immunomodulatory agents benefit a small percentage of patients with oral cancer (OC), a subset of head and neck cancer. Cathepsin S (CTSS), a lysosomal protease, has been frequently associated with tumor immunity. This study aim…
View article: RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway
RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway Open
Ribosomal RNA Processing 9 (RRP9) is a gene associated with ribosomal function, and studies have demonstrated that its expression is aberrantly regulated in various tumor types, correlating with tumor progression. However, the specific rol…
View article: Case Report: A very rare case of diffuse large B-cell lymphoma with cardiac and ovarian involvement
Case Report: A very rare case of diffuse large B-cell lymphoma with cardiac and ovarian involvement Open
Background Diffuse large B-cell lymphoma (DLBCL) is the most prevalent type of aggressive lymphoma, commonly spreading to sites such as the lymph nodes, spleen, bone marrow, liver, lungs, and central nervous system. However, metastasis to …
View article: Aromatic Molecular Compatibility Attenuates Influenza Virus-Induced Acute Lung Injury via the Lung–Gut Axis and Lipid Droplet Modulation
Aromatic Molecular Compatibility Attenuates Influenza Virus-Induced Acute Lung Injury via the Lung–Gut Axis and Lipid Droplet Modulation Open
Background: Acute lung injury (ALI) is a major cause of death in patients with various viral pneumonias. Our team previously identified four volatile compounds from aromatic Chinese medicines. Based on molecular compatibility theory, we de…
View article: Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure
Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure Open
Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects. This stud…
View article: Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance
Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance Open
View article: Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications
Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications Open
Human induced pluripotent stem cell (iPSC)-derived lung organoids, engineered to carry targeted genes, offer a robust platform for investigating mechanistic insights in lung research. Although lentiviral vectors (LVVs) are highly effective…
View article: Stratified Impact of Therapies on Anaplastic Thyroid Cancer Outcomes in the Pre-Gene-Targeted Therapy Era
Stratified Impact of Therapies on Anaplastic Thyroid Cancer Outcomes in the Pre-Gene-Targeted Therapy Era Open
Background Anaplastic thyroid cancer (ATC) is a highly lethal disease, often diagnosed with advanced locoregional and distant metastases, resulting in a median survival of just 3–5 months. This study determines the stratified effectiveness…
View article: Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extraction
Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extraction Open
Pole tower grounding bodies are part of the normal structure of the power system, providing relief from fault currents and equalizing overvoltage channels. They are important devices; however, in the harsh environment of the soil, they are…
View article: Engineering sulfonated polymers for the removal of ultra-trace complexed Cr(III) in tris(2-carboxyethyl) isocyanurate photoresist resin monomers
Engineering sulfonated polymers for the removal of ultra-trace complexed Cr(III) in tris(2-carboxyethyl) isocyanurate photoresist resin monomers Open
The semiconductor manufacturing industry imposes stringent requirements on the metal ion content of photoresist resin monomers. Tris(2-carboxyethyl) isocyanurate (H3tci), a critical raw material for photoresist resin monomers, inevitably i…
View article: Alveolar macrophages are early targets of mumps virus
Alveolar macrophages are early targets of mumps virus Open
Formerly a common childhood pathogen, mumps virus (MuV) remains active worldwide, despite relatively high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellu…
View article: Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia Open
Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. Although the ensuing compression to the fetal lung causes lung hypoplasia, specific cellular phenotypes and developmental signaling defects in t…
View article: Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance
Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance Open
Zinc finger protein 263 (ZNF263) is frequently upregulated in various tumor types; however, its function and regulatory mechanism in colorectal cancer (CRC) have not yet been elucidated. In this study, the expression of ZNF263 was systemat…
View article: Halogenated Adenine and Adenosine Natural Products in <i>Streptomyces</i> sp. JCM9888
Halogenated Adenine and Adenosine Natural Products in <i>Streptomyces</i> sp. JCM9888 Open
Ascamycin 1 and dealanylascamycin 2 are adenosine containing nucleoside antibiotics carrying the rare 5’‐ O ‐sulfamoyl ribose motif and a chlorine atom attached to C2 of the adenine ring. Gene knockouts (Δ acmK and Δ acmJ ) in the producin…
View article: <scp>NMC</scp>‐4 Ameliorates Depression‐Like Behavior and Neuroinflammation Caused by Chronic Unpredictable Mild Stress
<span>NMC</span>‐4 Ameliorates Depression‐Like Behavior and Neuroinflammation Caused by Chronic Unpredictable Mild Stress Open
Depression is a prevalent mental disorder, but the side effects of antidepressants also make depressed patients resistant. Effective and safe antidepressants should be developed from traditional herbs, with the aim of reducing the side eff…
View article: A Pan-Cancer Analysis of the Oncogenic Role of Transcription Factor 3 in Human Tumors
A Pan-Cancer Analysis of the Oncogenic Role of Transcription Factor 3 in Human Tumors Open
Background: It has been proposed that transcription factor 3 (TCF3) is involved in the development of lymphocytic malignancies. However, no systematic pan cancer analysis has been conducted, and the role of TCF3 in human cancer prognosis a…
View article: Insight into enhancing the performance of sludge dewatering using a novel flocculant CS-TA prepared through free radical-mediated conjugation
Insight into enhancing the performance of sludge dewatering using a novel flocculant CS-TA prepared through free radical-mediated conjugation Open
Flocculation is one of the most significant conditioning methods for sludge dewatering. In the present study, a novel flocculant CS-TA, which was prepared through free radical-mediated conjugation of tannic acid (TA) and chitosan (CS), was…
View article: Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development Open
View article: Radioactive iodine therapy improves overall survival outcome in oncocytic carcinoma of the thyroid by reducing death risks from noncancer causes: A competing risk analysis of 4641 patients
Radioactive iodine therapy improves overall survival outcome in oncocytic carcinoma of the thyroid by reducing death risks from noncancer causes: A competing risk analysis of 4641 patients Open
Background Oncocytic carcinoma of the thyroid (OCA) is an independent type of thyroid cancer. Radioactive iodine (RAI) therapy was frequently administered to OCA patients, but its contribution to improving survival is indefinite. Methods 4…
View article: Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study
Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study Open
Introduction In light of the public health burden of the COVID-19 pandemic, boosting the safety and immunogenicity of COVID-19 vaccines is of great concern. Numerous Traditional Chinese medicine (TCM) preparations have shown to beneficiall…
View article: High‐Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single‐Nuclei <scp>RNA</scp> Sequencing
High‐Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single‐Nuclei <span>RNA</span> Sequencing Open
Introduction The function of the vocal folds (VFs) is determined by the phenotype, abundance, and distribution of differentiated cells within specific microenvironments. Identifying this histologic framework is crucial in understanding lar…
View article: Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids
Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids Open
Summary To investigate the co-development of vasculature, mesenchyme, and epithelium crucial for organogenesis and the acquisition of organ-specific characteristics, we constructed a human pluripotent stem cell-derived organoid system comp…
View article: Insight into Enhancing the Performance of Sludge Dewatering Using Modified Tannic Acid: Synthesis, Characterization and Application
Insight into Enhancing the Performance of Sludge Dewatering Using Modified Tannic Acid: Synthesis, Characterization and Application Open
View article: Identification of Potential Factors for the Promotion of Fucoxanthin Synthesis by Methyl Jasmonic Acid Treatment of Phaeodactylum tricornutum
Identification of Potential Factors for the Promotion of Fucoxanthin Synthesis by Methyl Jasmonic Acid Treatment of Phaeodactylum tricornutum Open
Fucoxanthin, a vital secondary metabolite produced by marine diatoms, has great economic value and research potential. However, its popularization and application have been greatly restricted due to its low content, difficult extraction, a…
View article: Ecological Benefits and Plant Landscape Creation in Urban Parks: A Study of Nanhu Park, Hefei, China
Ecological Benefits and Plant Landscape Creation in Urban Parks: A Study of Nanhu Park, Hefei, China Open
Plant landscape creation in urban parks is an important aspect of urban ecological construction under the goal of “carbon neutrality”. In this study, the plant community of Nanhu Park in Hefei City was considered the research subject, and …