Xin Zhao
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View article: Inhibitory effects of Lactobacillus fermentum TKSN02 isolated from Xinjiang cheese on obesity induced by high-fat diet in mice and its gut microbiota modulation effects
Inhibitory effects of Lactobacillus fermentum TKSN02 isolated from Xinjiang cheese on obesity induced by high-fat diet in mice and its gut microbiota modulation effects Open
This study aimed to investigate the anti-obesity effects of Lactobacillus fermentum TKSN02 and its role in modulating gut microbiota. Biochemical assays, tissue section analysis, and qPCR were employed to evaluate serum and tissue paramete…
View article: An optimized protocol for plant extracellular vesicle isolation from Ophiopogon japonicus root: a comparative evaluation based on miRNA cargo
An optimized protocol for plant extracellular vesicle isolation from Ophiopogon japonicus root: a comparative evaluation based on miRNA cargo Open
Background: Plant extracellular vesicles (PEVs), hold significant therapeutic potential due to their roles in intercellular communication and cross-kingdom regulation, primarily mediated by their miRNA cargo. However, isolating high-purity…
View article: Case Report: A case of surgical and enzyme replacement therapy for type I Gaucher disease complicating femoral shaft pathological fracture
Case Report: A case of surgical and enzyme replacement therapy for type I Gaucher disease complicating femoral shaft pathological fracture Open
Gaucher disease (GD) is an inherited lysosomal storage disorder caused by glucocerebrosidase (GCase) deficiency. A 35-year-old male patient was admitted to our hospital due to left thigh pain and restricted mobility for 10 h. Following com…
View article: Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization
Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization Open
Cardiovascular progenitors (CPs) are responsible for generating diverse cardiac cell populations, exhibiting significant transcriptional heterogeneity. However, the mechanisms regulating fate plasticity among heterogeneous CP subpopulation…
View article: Network of anxiety and depression symptoms in older Chinese adults living alone: a cross-sectional study
Network of anxiety and depression symptoms in older Chinese adults living alone: a cross-sectional study Open
Background With the rapid aging of China’s population, the proportion of older adults living alone has increased significantly, bringing their mental health concerns into sharp focus. This study aims to explore the network structure of anx…
View article: Preparation and evaluation of a novel composite phase change material for drilling in hydrate formations
Preparation and evaluation of a novel composite phase change material for drilling in hydrate formations Open
In the process of gas hydrate drilling, the drilling fluid is prone to intruding into the formation, changes the formation temperature, pressure, and chemical conditions of hydrate occurrence, causes the formation hydrate decomposition aro…
View article: Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals
Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals Open
Antibody-drug conjugates (ADCs) represent a novel class of biopharmaceuticals comprising monoclonal antibodies covalently conjugated to cytotoxic agents via engineered chemical linkers. This combination enables targeted delivery of cytotox…
View article: Smoking and High‐Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects
Smoking and High‐Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects Open
Smoking and high‐altitude (HA) exposure both adversely affect human health, with smoking linked to various cancers and high‐altitude environments causing physiological and neurological changes. Although the effects of smoking and HA exposu…
View article: Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury Open
Cellular senescence is a key element in the development of chronic kidney disease (CKD) following acute kidney injury (AKI). However, the mechanisms behind cellular senescence remain unclear. Here, we establish an association between Panne…
View article: Process Optimization of Stir‐Fried <scp><i>Inonotus hispidus</i></scp> Based on the Box–Behnken Design‐Response Surface Method and the Component Variations During the Stir‐Frying Process
Process Optimization of Stir‐Fried <span><i>Inonotus hispidus</i></span> Based on the Box–Behnken Design‐Response Surface Method and the Component Variations During the Stir‐Frying Process Open
The present study was designed to optimize the processing of Inonotus hispidus ( I. hispidus ) by single‐factor studies and response surface methodology (RSM). Stir‐frying temperature, stir‐frying time, and rotational speed of the stir‐fry…
View article: The overgrowth of structure-function coupling in premature brain during infancy
The overgrowth of structure-function coupling in premature brain during infancy Open
Although the rapid growth of brain structure and function during infancy has been well documented, relatively little is known about how these two developmental processes couple-an aspect that exhibits distinct patterns in adult brain. In t…
View article: Anti‐Obesity Effects of <scp><i>Leuconostoc mesenteroides</i></scp> 4‐Fermented Lemon Peel Filtrate on <scp>HFD</scp>‐Induced Obese Mice via <scp>NFκB</scp>/ <scp>PPAR</scp>‐γ Pathway
Anti‐Obesity Effects of <span><i>Leuconostoc mesenteroides</i></span> 4‐Fermented Lemon Peel Filtrate on <span>HFD</span>‐Induced Obese Mice via <span>NFκB</span>/ <span>PPAR</span>‐γ Pathway Open
Obesity is a major health problem associated with Type 2 diabetes, non‐alcohol fatty liver disease (NAFLD), and atherosclerosis. Functional lactic acid bacteria‐fermented products have been reported to have potential anti‐obese effect. The…
View article: <i>Limosilactobacillus fermentum</i> XY18 Relieves CCl<sub>4</sub>‐Induced Acute Liver Injury in Mice by Antioxidant and Anti‐Inflammatory
<i>Limosilactobacillus fermentum</i> XY18 Relieves CCl<sub>4</sub>‐Induced Acute Liver Injury in Mice by Antioxidant and Anti‐Inflammatory Open
This study investigated whether Limosilactobacillus fermentum XY18 (LF‐XY18) prevents carbon tetrachloride (CCl 4 )‐induced mice acute liver injury (ALI) by alleviating oxidative stress and inflammation. LF‐XY18 reduced liver weight, impro…
View article: Association between incidence of hypomagnesemia and better prognosis of NSCLC: A case on the immortal time bias
Association between incidence of hypomagnesemia and better prognosis of NSCLC: A case on the immortal time bias Open
Background Previous studies predominantly reported that the occurrence of hypomagnesemia was associated with improved cancer prognoses. However, utilizing publicly available data, we demonstrated the presence of bias in this association, a…
View article: Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report
Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report Open
Acute Q fever, caused by Coxiella burnetii, is a zoonotic infection presenting with non-specific symptoms such as high fever, severe headache and myalgia, making it challenging to diagnose. Traditional diagnostic methods often fall short d…
View article: Clinical effects of anweiyang capsule and Pinellia decoction for eradication of Helicobacter pylori and healing of peptic ulcers
Clinical effects of anweiyang capsule and Pinellia decoction for eradication of Helicobacter pylori and healing of peptic ulcers Open
Peptic ulcers are a prevalent and often chronic condition within the digestive system, frequently prone to recurrence. This study aims to evaluate the clinical effects of Anweiyang capsule combined with Pinellia Heart-Draining Decoction on…
View article: An isolated salt-tolerant Tetragenococcus halophilus 2MH-3 improved the volatile flavor of low-salt fermented fish sauce by regulating the microbial community
An isolated salt-tolerant Tetragenococcus halophilus 2MH-3 improved the volatile flavor of low-salt fermented fish sauce by regulating the microbial community Open
The application of low-salt fish sauce is limited by its tendency to spoil easily and inadequate flavor generation. Herein, a salt-tolerant Tetragenococcus halophilus 2MH-3 strain with strong abilities of enzyme production and biogenic ami…