Yali Zhao
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View article: Visualized Analysis of Adolescent Non-Suicidal Self-Injury and Comorbidity Networks
Visualized Analysis of Adolescent Non-Suicidal Self-Injury and Comorbidity Networks Open
Non-suicidal self-injury (NSSI) has become an increasingly salient mental health concern among adolescents, and it commonly co-occurs with depression, anxiety, borderline personality disorder, substance use, and childhood maltreatment, for…
View article: CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation
CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation Open
Background: Myocardial ischemia/reperfusion (I/R) injury contributes significantly to cardiac dysfunction following myocardial infarction, mainly due to excessive oxidative stress and mitochondrial injury. Despite advances in reperfusion t…
View article: Comprehensive Bioinformatics Analysis of Angiogenesis in Knee Osteoarthritis: Identification of Diagnostic Biomarkers and Therapeutic Targets
Comprehensive Bioinformatics Analysis of Angiogenesis in Knee Osteoarthritis: Identification of Diagnostic Biomarkers and Therapeutic Targets Open
Background Osteoarthritis (OA) is a prevalent disabling disease characterized by cartilage degeneration, subchondral sclerosis, and synovial abnormalities, significantly impairing quality of life. Its pathogenesis involves genetic and immu…
View article: Unmet long-term care needs and their association with health-related quality of life among Chinese oldest-old population
Unmet long-term care needs and their association with health-related quality of life among Chinese oldest-old population Open
The prevalence of unmet LTC needs was higher in China than its counterpart in high-income countries, especially among those with socio-economic deprivation. Individuals with unmet LTC needs experience lower quality-adjusted life years (QAL…
View article: Risk factors and an interpretability tool of in-hospital mortality in critically ill patients with acute myocardial infarction
Risk factors and an interpretability tool of in-hospital mortality in critically ill patients with acute myocardial infarction Open
We built the BRF model and the web-based tool by the model algorithm. The model effect has been verified externally. The tool can help clinical decision-making.
View article: Macrocarpal I induces immunogenic cell death and synergizes with immune checkpoint inhibition by targeting tubulin and PARP1 in colorectal cancer
Macrocarpal I induces immunogenic cell death and synergizes with immune checkpoint inhibition by targeting tubulin and PARP1 in colorectal cancer Open
Colorectal cancer (CRC) presents an obstacle to immunotherapy, primarily because most cases are microsatellite stable (MSS) tumors, which are often described as “cold tumors” with limited immunogenicity. Recent studies have indicated that …
View article: Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma
Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma Open
FCER1G+ cells infiltration may help to predict the prognosis of ESCC. The combined detection of FCER1G and CD163 has a higher prognostic value.
View article: Chronic Pain and Late‐Life Depression are Positively Associated in Chinese Centenarians and Oldest‐Old Adults
Chronic Pain and Late‐Life Depression are Positively Associated in Chinese Centenarians and Oldest‐Old Adults Open
Objectives: Aging is an inevitable process. Chronic pain and late‐life depression frequently coexist in older adults. This study was aimed to explore the association between chronic pain and late‐life depression in Chinese centenarians and…
View article: Calf circumference was negatively associated with all-cause mortality among the Chinese centenarians: a prospective study with a 5-year follow-up
Calf circumference was negatively associated with all-cause mortality among the Chinese centenarians: a prospective study with a 5-year follow-up Open
Background Sarcopenia is an aging-related disorder characterized by a loss of muscle mass and function. Calf circumference (CC) is a useful surrogate marker of muscle mass and function. This prospective study was designed to investigate th…
View article: Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians: evidence from China Hainan Centenarian Cohort Study
Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians: evidence from China Hainan Centenarian Cohort Study Open
In centenarians, poor sleep quality raises the risk of hypertension, with complement C3 as a mediator. Additionally, nighttime sleep durations of ≤ 6 h or > 9 h increases the risk of high PP, mediated by lymphocyte count, NLR, and SII.
View article: <b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b>
<b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b> Open
AbstractOvernutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progressio…
View article: <b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b>
<b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b> Open
AbstractOvernutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progressio…
View article: Identification of BAF60b as a Chromatin-Remodeling Checkpoint of Diet-Induced Fatty Liver Disease
Identification of BAF60b as a Chromatin-Remodeling Checkpoint of Diet-Induced Fatty Liver Disease Open
Overnutrition has gradually become the primary causative factor in nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progression remain…
View article: <b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b>
<b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b> Open
AbstractOvernutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progressio…
View article: Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study
Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study Open
Anemia is associated with an increased risk of all-cause mortality in Chinese centenarians. Further research will be needed to collect more comprehensive data on the etiology of anemia and causes of death in centenarians.
View article: Chlorogenic acid attenuates cardiac hypertrophy via up‐regulating Sphingosine‐1‐phosphate receptor1 to inhibit endoplasmic reticulum stress
Chlorogenic acid attenuates cardiac hypertrophy via up‐regulating Sphingosine‐1‐phosphate receptor1 to inhibit endoplasmic reticulum stress Open
Aims Cardiac hypertrophy, an adaptive response of the heart to stress overload, is closely associated with heart failure and sudden cardiac death. This study aimed to investigate the therapeutic effects of chlorogenic acid (CGA) on cardiac…
View article: Association of Sleep Status With Cognitive Functions in Centenarians: Evidence From Hainan Centenarian Cohort
Association of Sleep Status With Cognitive Functions in Centenarians: Evidence From Hainan Centenarian Cohort Open
Objectives This study aimed to analyze the association between sleep quality, sleep duration, and cognitive functions among centenarians. Methods The baseline data of the China Hainan Centenarians Cohort Study served as the foundation for …
View article: Deciphering Immune Landscape Remodeling Unravels the Underlying Mechanism for Synchronized Muscle and Bone Aging
Deciphering Immune Landscape Remodeling Unravels the Underlying Mechanism for Synchronized Muscle and Bone Aging Open
Evidence from numerous studies has revealed the synchronous progression of aging in bone and muscle; however, little is known about the underlying mechanisms. To this end, human muscles and bones are harvested and the aging‐associated tran…
View article: Association of sleep status with depressive state in centenarians: Evidence from Hainan centenarian cohort
Association of sleep status with depressive state in centenarians: Evidence from Hainan centenarian cohort Open
The findings of this study indicate that there is an association between poor sleep quality and depressive states in centenarians. Furthermore, both sleep quality and long/short total sleep duration are associated with depressive states in…
View article: Homocysteine Combined with Apolipoprotein B as Serum Biomarkers for Predicting Carotid Atherosclerosis in the Oldest-Old
Homocysteine Combined with Apolipoprotein B as Serum Biomarkers for Predicting Carotid Atherosclerosis in the Oldest-Old Open
SBP, HR, Hcy and ApoB are independent risk factors for CAS in the oldest-old. The specific set of biomarkers and their combination with other risk markers may be a promising strategy for assessing CAS in the elderly, especially in global a…
View article: C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, and Long-Term Mortality in Chinese Centenarians
C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, and Long-Term Mortality in Chinese Centenarians Open
This cohort study explores whether biomarkers of inflammation-related aging, including C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio, are associated with long-term mortality in Chinese centenarians.