Yachen Li
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View article: Splicing to keep splicing: A feedback system for cellular homeostasis and state transition
Splicing to keep splicing: A feedback system for cellular homeostasis and state transition Open
Background Alternative splicing (AS) plays a crucial role in regulating gene expression and governing proteomic diversity by generating multiple protein isoforms from a single gene. Increasing evidence has highlighted the regulation for pr…
View article: AcABI5a integrates abscisic acid signaling to developmentally modulate fruit ascorbic acid biosynthesis in kiwifruit
AcABI5a integrates abscisic acid signaling to developmentally modulate fruit ascorbic acid biosynthesis in kiwifruit Open
Consumers value highly the nutritional content and flavor of fresh fruits, which are influenced by endogenous plant hormones. However, the molecular mechanisms governing the hormonal regulation of essential nutrients such as ascorbic acid …
View article: Tunable Tactile Synapses Enabled by Erasable Doping in Iongel‐Gated Nanotube Network Transistors
Tunable Tactile Synapses Enabled by Erasable Doping in Iongel‐Gated Nanotube Network Transistors Open
The tunable synaptic plasticity of biological sensory systems plays a pivotal role in efficient information processing and adaptation. Bio‐mimetic sensory synaptic devices, particularly those for tactile synapses, usually lack effective se…
View article: Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK–STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking
Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK–STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking Open
Background Clozapine exhibits significant therapeutic efficacy in schizophrenia, especially treatment‐resistant schizophrenia. However, clozapine can cause agranulocytosis, a fatal adverse effect, and the aim of this study is to explore th…
View article: Splicing to orchestrate cell fate
Splicing to orchestrate cell fate Open
Alternative splicing (AS) plays a critical role in gene expression by generating protein diversity from single genes. This review provides an overview of the role of AS in regulating cell fate, focusing on its involvement in processes such…
View article: Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis
Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis Open
View article: Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis
Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis Open
Background The interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear. Methods We…
View article: Low-grade heat recycling of vertical thermoelectric cells based on thermal-induced electric double layer
Low-grade heat recycling of vertical thermoelectric cells based on thermal-induced electric double layer Open
Employing electric double-layer (EDL) capacitors to harvest low-grade heat (LGH) is a novel technique in the high-efficiency energy absorption field. This work reports the fabrication of a vertical thermoelectric cell, based on a nanoporou…
View article: Metabonomics study on the effects of acupuncture and moxibustion in a rat knee osteoarthritis model
Metabonomics study on the effects of acupuncture and moxibustion in a rat knee osteoarthritis model Open
For elucidating effects of acupuncture and moxibustion on the metabolism of knee osteoarthritis (KOA) in rats, A method for metabolite analysis based on high throughput liquid chromatography-tandem mass spectrometry (LC-MS) was used to inv…
View article: Residential greenness mitigates mortality risk from short-term airborne particulate exposure: An individual-level case-crossover study
Residential greenness mitigates mortality risk from short-term airborne particulate exposure: An individual-level case-crossover study Open
Short-term exposure to particulate air pollution was associated with elevated risks of nonaccidental and circulatory death, and individuals residing in higher neighborhood greenness possessed lower risk of PM-related mortality. These findi…
View article: Terahertz multi-band absorber and dual-bandwidth polarization converter based on VO2 and graphene
Terahertz multi-band absorber and dual-bandwidth polarization converter based on VO2 and graphene Open
A terahertz metamaterial with multiple functions is proposed based on patterned graphene, concentric gold rings and gold columns, and vanadium dioxide (VO2). By adjusting the temperature of VO2, it can be in metal state or insulator state,…
View article: Ambient PM2.5, ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005–2018)
Ambient PM2.5, ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005–2018) Open
View article: Emergency Department Visits in Children Associated with Exposure to Ambient PM1 within Several Hours
Emergency Department Visits in Children Associated with Exposure to Ambient PM1 within Several Hours Open
Background: Emerging evidence has integrated short-term exposure to PM1 with children’s morbidity and mortality. Nevertheless, most available studies have been conducted on a daily scale, ignoring the exposure variations over the span of a…
View article: Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9 Open
Osteoarthritis (OA) is a type of common degenerative joint disorder, in which adipose mesenchymal stem cells (ADSCs) and the secreted exosomes play an important role. The purpose of this study was to investigate the role and mechanism of e…
View article: Corrigendum to: “Comprehensive analysis of triphenyl phosphate — An environmental explanation of colorectal cancer progression” [Ecotoxicol. Environ. Saf. 241 (2022) 113778]
Corrigendum to: “Comprehensive analysis of triphenyl phosphate — An environmental explanation of colorectal cancer progression” [Ecotoxicol. Environ. Saf. 241 (2022) 113778] Open
View article: Effectiveness of acupuncture for irritable bowel syndrome: Protocol for a scoping review of systematic reviews and meta-analyses
Effectiveness of acupuncture for irritable bowel syndrome: Protocol for a scoping review of systematic reviews and meta-analyses Open
Background: Irritable bowel syndrome (IBS) is a common functional bowel disorder. Many systematic reviews/meta-analyses indicate that acupuncture and related therapies are effective for IBS. However, the robustness of the results in the sy…
View article: Comprehensive analysis of triphenyl phosphate: An environmental explanation of colorectal cancer progression
Comprehensive analysis of triphenyl phosphate: An environmental explanation of colorectal cancer progression Open
View article: Effectiveness of acupuncture for irritable bowel syndrome: Protocol for a scoping review of systematic reviews and meta-analyses
Effectiveness of acupuncture for irritable bowel syndrome: Protocol for a scoping review of systematic reviews and meta-analyses Open
View article: Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia and major depressive disorder versus patients with bipolar disorder when compared to controls.
Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia and major depressive disorder versus patients with bipolar disorder when compared to controls. Open
Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of…
View article: β2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
β2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway Open
Activation of the β2 adrenergic receptor (β2AR) on immune cells has been reported to possess anti-inflammatory properties, however, the pro-inflammatory properties of β2AR activation remain unclear. In this study, using rat primary mesence…
View article: Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy
Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy Open
New folate receptor targeted nano-micelles enhanced the anticancer effect of doxorubicin by shBeclin1 with the blockade of the autophagy process.
View article: Chlorpyrifos Induces<i>MLL</i>Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells
Chlorpyrifos Induces<i>MLL</i>Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells Open
Household pesticide exposure during pregnancy has been associated with a more than 2-fold increased risk in infant leukemia, and chlorpyrifos (CPF) is among the most frequently applied insecticides. During early fetal development, liver is…