Yun Liang
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View article: Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial
Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial Open
This trial is registered on 4 September 2022. Registration number: ChiCTR2200063321. Source(s) of funding: Traditional Chinese Medicine Inheritance and Innovation "Ten-Hundred-Thousand" Talents Program (Qihuang Program, grant number:2019-Q…
View article: Perfluorooctanoic acid (PFOA) induces apoptosis by disrupting mitochondrial function via the SIRT1/FOXO1-SOD2 pathway in human granulosa cells: Implications for PCOS
Perfluorooctanoic acid (PFOA) induces apoptosis by disrupting mitochondrial function via the SIRT1/FOXO1-SOD2 pathway in human granulosa cells: Implications for PCOS Open
Perfluorooctanoic acid (PFOA), a widely used perfluoroalkyl substance (PFAS), has been associated with adverse reproductive health outcomes, including polycystic ovary syndrome (PCOS). However, the molecular mechanisms remain poorly unders…
View article: Case Report: Primary cardiac diffuse large B-cell lymphoma with sick sinus syndrome and literature review on disease management and therapeutic strategies
Case Report: Primary cardiac diffuse large B-cell lymphoma with sick sinus syndrome and literature review on disease management and therapeutic strategies Open
Background Primary cardiac diffuse large B-cell lymphoma (DLBCL) is a rare but clinically challenging extranodal lymphoma. Diagnosis and management are often complicated due to its nonspecific symptoms and rarity. Case Report We reported a…
View article: Trends and hotspots in chronic thromboembolic pulmonary hypertension research: A bibliometric and visualization analysis from 2004 to 2024
Trends and hotspots in chronic thromboembolic pulmonary hypertension research: A bibliometric and visualization analysis from 2004 to 2024 Open
View article: Mechanisms of Leydig Cell Aging and Obesity-Related Hypogonadism in Men: A Review
Mechanisms of Leydig Cell Aging and Obesity-Related Hypogonadism in Men: A Review Open
The rising prevalence of overweight, obesity, and late-onset hypogonadism (LOH) is seriously affecting the quality of life of middle-aged and older men. LOH is a testosterone deficiency syndrome that is closely associated with aging. Its m…
View article: The Effect of Pre-Filter and Main-Filter Media Matching on the Performance of an Ultra-High-Efficiency Two-Stage Filtration System
The Effect of Pre-Filter and Main-Filter Media Matching on the Performance of an Ultra-High-Efficiency Two-Stage Filtration System Open
Ultra-high-efficiency filter media ensure high air cleanliness but need periodic replacement due to pressure drop increase. Adding a pre-filter can extend the filtration system’s service lifetime, yet the pre-filter and main-filter matchin…
View article: Efficacy and safety of surufatinib in the treatment of thymic neuroendocrine tumors: a 102-case retrospective study.
Efficacy and safety of surufatinib in the treatment of thymic neuroendocrine tumors: a 102-case retrospective study. Open
Introduction or hypothesis The SANET-ep study confirmed that patients with non-pancreatic NET could benefit from surufatinib treatment compared with placebo. However, there is a lack of sufficient retrospective data on surufatinib’s effica…
View article: Experimental and Simulation Study of Particle Deposition Characteristics and Pressure Drop Evolution in Pleated Filter Media
Experimental and Simulation Study of Particle Deposition Characteristics and Pressure Drop Evolution in Pleated Filter Media Open
Pleated filter media are widely used in particulate filtration, but the particle deposition and pressure drop during particle loading remain insufficiently explored. This study visualizes the particle deposition patterns in pleated filter …
View article: Electrodeposition of Bismuth Dendrites on Oxide-Derived Copper Foam Enhancing Electrochemical CO2 Reduction to Formate
Electrodeposition of Bismuth Dendrites on Oxide-Derived Copper Foam Enhancing Electrochemical CO2 Reduction to Formate Open
The electrochemical CO2 reduction reaction (CO2RR) to formate offers a promising pathway to mitigate the energy crisis and realize carbon neutrality. Bismuth (Bi), as a metal catalyst for the CO2RR, is considered to have great potential in…
View article: Nicotine-Induced Transient Activation of Monocytes Facilitates Immunosuppressive Macrophage Polarization that Restrains T Helper 17 Cell Expansion
Nicotine-Induced Transient Activation of Monocytes Facilitates Immunosuppressive Macrophage Polarization that Restrains T Helper 17 Cell Expansion Open
View article: Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty Open
Introduction Obesity-related precocious puberty is induced by obesity, and acupoint catgut embedding (ACE) therapy is known to treat obesity. This study aims to validate the hypothesis that ACE can delay the onset of obesity-related precoc…
View article: Experimental and Numerical Investigation of Slip Effect on Nanofiber Filter Performance at Low Pressures
Experimental and Numerical Investigation of Slip Effect on Nanofiber Filter Performance at Low Pressures Open
Nanofiber filters are widely used in air filtration applications due to their superior performance over microfiber filters. Velocity slip around nanofibers has been identified as a key factor contributing to their high figure of merit, yet…
View article: Monocarboxylate transporter 4 facilitates Mycobacterium tuberculosis survival through NF-κB p65-mediated interleukin-10 production
Monocarboxylate transporter 4 facilitates Mycobacterium tuberculosis survival through NF-κB p65-mediated interleukin-10 production Open
View article: Lenalidomide, rituximab, and methotrexate are effective in newly diagnosed primary central nervous system lymphoma
Lenalidomide, rituximab, and methotrexate are effective in newly diagnosed primary central nervous system lymphoma Open
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View article: Clinical characteristics and outcomes of COVID-19 infection in Chinese patients with hematologic malignancies in the Omicron era
Clinical characteristics and outcomes of COVID-19 infection in Chinese patients with hematologic malignancies in the Omicron era Open
Patients with hematologic malignancies are often immunodeficient and therefore have a higher risk of severe symptoms from coronavirus disease 2019 (COVID-19). We retrospectively examined a cohort of 289 patients from 16 hospitals in Zhejia…
View article: Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review
Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review Open
Composite lymphoma (CL) involving B-cell lymphoma and T-cell lymphoma is extremely rare. Herein, we report three such cases using immunohistochemistry, flow cytometry, and the next-generation sequencing (NGS) to identify the pathological a…
View article: R‐CHOP WITH SINTILIZUMAB IN FIRST‐LINE TREATMENT OF LARGE B‐CELL LYMPHOMA PATIENTS WITH TP53 MUTATIONS AND PD‐L1 EXPRESSION: A RANDOMIZED, MULTICENTER CLINICAL STUDY
R‐CHOP WITH SINTILIZUMAB IN FIRST‐LINE TREATMENT OF LARGE B‐CELL LYMPHOMA PATIENTS WITH TP53 MUTATIONS AND PD‐L1 EXPRESSION: A RANDOMIZED, MULTICENTER CLINICAL STUDY Open
Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma, which accounts for approximately 30%–40% of all cases of non-Hodgkin lymphoma (NHL). Although 60% of patients can be cured by standard R-CHO…
View article: Rituximab with high-dose methotrexate is effective and cost-effective in newly diagnosed primary central nervous system lymphoma
Rituximab with high-dose methotrexate is effective and cost-effective in newly diagnosed primary central nervous system lymphoma Open
View article: Efficacy and Safety of Esketamine Combined with Antidepressants for Treatment-Resistant Depression: A Meta-Analysis
Efficacy and Safety of Esketamine Combined with Antidepressants for Treatment-Resistant Depression: A Meta-Analysis Open
Esketamine + antidepressant has an obvious curative effect in treatment-resistant depression and can rapidly improve depression in patients, quality of life and satisfaction, but minor adverse reactions can occur.
View article: Multiple myeloma with isolated central nervous system relapse after autologous stem cell transplantation: A case report and review of the literature
Multiple myeloma with isolated central nervous system relapse after autologous stem cell transplantation: A case report and review of the literature Open
Patients with multiple myeloma (MM) rarely present with central nervous system (CNS) involvement as a manifestation of extramedullary disease (EMD), a condition that is associated with poor prognosis. CNS relapse without evidence of system…
View article: Effect of iodoacetic acid on the reproductive system of male mice
Effect of iodoacetic acid on the reproductive system of male mice Open
Iodoacetic acid (IAA) is one of the most common water disinfection byproducts (DBPs). Humans and animals are widely and continuously exposed to it. Many species of water DBPs are harmful to the reproductive system of organisms. Nevertheles…
View article: Aberrantly Activated APOBEC3B Is Associated With Mutant p53-Driven Refractory/Relapsed Diffuse Large B-Cell Lymphoma
Aberrantly Activated APOBEC3B Is Associated With Mutant p53-Driven Refractory/Relapsed Diffuse Large B-Cell Lymphoma Open
Tumor protein 53 ( TP53 ) mutation predicts an unfavorable prognosis in diffuse large B-cell lymphoma (DLBCL), but the molecular basis for this association remains unclear. In several malignancies, the cytidine deaminase apolipoprotein B m…
View article: Rituximab With High-Dose Methotrexate In Newly Diagnosed Primary Central Nervous System Lymphoma: a Single-Center Experience From China
Rituximab With High-Dose Methotrexate In Newly Diagnosed Primary Central Nervous System Lymphoma: a Single-Center Experience From China Open
Induction chemotherapy based on high-dose methotrexate is considered as the standard approach for newly diagnosed primary central nervous system lymphomas (PCNSLs). However, the best combination chemotherapeutic regimen remains unclear. Th…
View article: Single Cell RNA Sequencing Analysis of Human Kidney Reveals the Presence of ACE2 Receptor: A Potential Pathway of COVID-19 Infection
Single Cell RNA Sequencing Analysis of Human Kidney Reveals the Presence of ACE2 Receptor: A Potential Pathway of COVID-19 Infection Open
View article: Translaminar facet joint screw insertion with a rapid prototyping guide template: a cadaver study
Translaminar facet joint screw insertion with a rapid prototyping guide template: a cadaver study Open
It is technically demanding and requires rich experience to insert the translaminar facet screw(TFS) via the paramedian mini-incision approach. It seems that it is easy to place the TFS using computer-assisted design and rapid prototyping(…
View article: Oculomotor nerve palsy as a preceding symptom of adult sporadic Burkitt lymphoma: A case report and review of the literature
Oculomotor nerve palsy as a preceding symptom of adult sporadic Burkitt lymphoma: A case report and review of the literature Open
Adult sporadic Burkitt lymphoma (BL) is a rare aggressive neoplasm and represents ~1-5% of all lymphomas diagnosed in adults. The disease exhibits an aggressive clinical manifestation, which frequently involves the central nervous system (…
View article: 062 VGLL3 is a key regulator of gender biased transcriptome changes and may explain female bias in lupus and other autoimmune diseases
062 VGLL3 is a key regulator of gender biased transcriptome changes and may explain female bias in lupus and other autoimmune diseases Open
View article: Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature
Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature Open
A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-year-old woman with transient pancytopenia, which manifested as a feve…