Yacine Tandjaoui-Lambiotte
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View article: Management of latent TB infection: a national survey of French physicians
Management of latent TB infection: a national survey of French physicians Open
International audience
View article: Lung ultrasonography for community-acquired pneumonia diagnosis
Lung ultrasonography for community-acquired pneumonia diagnosis Open
Over the past two decades, several studies have assessed the performance of lung ultrasonography in the diagnosis of community-acquired pneumonia (CAP). The performance of this diagnostic tool, when used by clinicians other than radiologis…
View article: Corrigendum to “Human metapneumovirus infection is associated with a substantial morbidity and mortality burden in adult inpatients” [Heliyon Volume 10, Issue 13, July 15, 2024, Article e33231]
Corrigendum to “Human metapneumovirus infection is associated with a substantial morbidity and mortality burden in adult inpatients” [Heliyon Volume 10, Issue 13, July 15, 2024, Article e33231] Open
[This corrects the article DOI: 10.1016/j.heliyon.2024.e33231.].
View article: Hematological features and alternate diagnoses in critically ill thrombotic antiphospholipid syndrome patients
Hematological features and alternate diagnoses in critically ill thrombotic antiphospholipid syndrome patients Open
View article: Human metapneumovirus infection is associated with a substantial morbidity and mortality burden in adult inpatients
Human metapneumovirus infection is associated with a substantial morbidity and mortality burden in adult inpatients Open
View article: Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 Open
View article: Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Open
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plu…
View article: Spectacular Improvement of Paradoxical Reaction in Tuberculosis after Tumor Necrosis Factor-Alpha Antagonist Therapy
Spectacular Improvement of Paradoxical Reaction in Tuberculosis after Tumor Necrosis Factor-Alpha Antagonist Therapy Open
View article: Acute respiratory distress syndrome due to monkeypox virus
Acute respiratory distress syndrome due to monkeypox virus Open
We report the first case of monkeypox virus (MPXV) associated acute respiratory distress syndrome (ARDS). A 34-year-old French woman with no medical history was admitted to the intensive care unit (ICU) for fever, altered mental status, hy…
View article: Correction: Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit
Correction: Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit Open
View article: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 Open
Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening…
View article: Systematic Review of the Key Factors Influencing the Indoor Airborne Spread of SARS-CoV-2
Systematic Review of the Key Factors Influencing the Indoor Airborne Spread of SARS-CoV-2 Open
The COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been plaguing the world since late 2019/early 2020 and has changed the way we function as a society, halting both economic and social activit…
View article: Additional file 2 of Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Additional file 2 of Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 Open
Additional file 2: Table S1. Number of genes tested and Genomic inflation factor for each model and variant set. Table S2. Complete results of the genome-wide burden joint analysis, trans-pipeline meta-analysis and trans-ethnic meta-analys…
View article: Spread of viruses, which measures are the most apt to control COVID-19?
Spread of viruses, which measures are the most apt to control COVID-19? Open
View article: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 Open
Background We previously reported inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity in 1-5% of unvaccinated patients with life-threatening COVID-19, and auto-antibodies against type I IFN in another 15-20% of cases…
View article: Prevalence, characteristics and outcome of cardiac manifestations in critically-ill antiphospholipid syndrome patients
Prevalence, characteristics and outcome of cardiac manifestations in critically-ill antiphospholipid syndrome patients Open
View article: Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs Open
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% o…
View article: The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies Open
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19…
View article: Environmental SARS-CoV-2 contamination in hospital rooms of patients with acute COVID-19
Environmental SARS-CoV-2 contamination in hospital rooms of patients with acute COVID-19 Open
View article: Characteristics and Outcomes of Patients in the ICU With Respiratory Syncytial Virus Compared With Those With Influenza Infection
Characteristics and Outcomes of Patients in the ICU With Respiratory Syncytial Virus Compared With Those With Influenza Infection Open
View article: The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies Open
SARS-CoV-2 infection fatality rate (IFR) doubles with every five years of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ~20% of deceased patients across age groups. In the genera…
View article: Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths Open
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in indiv…
View article: X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 Open
TLR7 and plasmacytoid dendritic cells are essential for type I IFN–dependent immunity to SARS-CoV-2 in the lungs.
View article: Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units
Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units Open
Introduction At the time of the worrying emergence and spread of bacterial resistance, reducing the selection pressure by reducing the exposure to antibiotics in patients with community-acquired pneumonia (CAP) is a public health issue. In…
View article: Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study
Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study Open
View article: Tyrosine Kinase Inhibitors for Acute Respiratory Failure Because of Non–small-Cell Lung Cancer Involvement in the ICU
Tyrosine Kinase Inhibitors for Acute Respiratory Failure Because of Non–small-Cell Lung Cancer Involvement in the ICU Open
View article: Epicardial adipose tissue and severe Coronavirus Disease 19
Epicardial adipose tissue and severe Coronavirus Disease 19 Open
Background Both visceral adipose tissue and epicardial adipose tissue (EAT) have pro-inflammatory properties. The former is associated with Coronavirus Disease 19 (COVID-19) severity. We aimed to investigate whether an association also exi…
View article: Viral Dispersion in the ICU: The Wind Effect
Viral Dispersion in the ICU: The Wind Effect Open
View article: Non–<i>C. difficile</i><i>Clostridioides</i> Bacteremia in Intensive Care Patients, France
Non–<i>C. difficile</i><i>Clostridioides</i> Bacteremia in Intensive Care Patients, France Open
Usually responsible for soft tissue infections, Clostridioides species can also cause bacteremia, life-threatening infections often requiring intensive care unit (ICU) admission. We conducted a multicenter retrospective study to investigat…
View article: COVID-19 critique et anticorps anti-Interféron : série de 11 cas
COVID-19 critique et anticorps anti-Interféron : série de 11 cas Open