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View article: Biocompatible Iron Oxide Nanoparticles Display Antiviral Activity Against Two Different Respiratory Viruses in Mice
Biocompatible Iron Oxide Nanoparticles Display Antiviral Activity Against Two Different Respiratory Viruses in Mice Open
This study highlights the antiviral activity of DMSA-IONP-10 against important human respiratory viruses.
View article: DMSA-coated IONPs trigger oxidative stress, mitochondrial metabolic reprograming and changes in mitochondrial disposition, hindering cell cycle progression of cancer cells
DMSA-coated IONPs trigger oxidative stress, mitochondrial metabolic reprograming and changes in mitochondrial disposition, hindering cell cycle progression of cancer cells Open
There is increasing interest in modulating the redox homeostasis of tumors since high levels of reactive oxygen species (ROS) make them more vulnerable to changes in these species. Nanomedicine offers promise in this context as such applic…
View article: Interaction of Iron Oxide Nanoparticles with Macrophages Is Influenced Distinctly by “Self” and “Non-Self” Biological Identities
Interaction of Iron Oxide Nanoparticles with Macrophages Is Influenced Distinctly by “Self” and “Non-Self” Biological Identities Open
Upon contact with biological fluids like serum, a protein corona (PC) complex forms on iron oxide nanoparticles (IONPs) in physiological environments and the proteins it contains influence how IONPs act in biological systems. Although the …
View article: Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells
Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells Open
Background Coronaviruses usually cause mild respiratory disease in humans but as seen recently, some human coronaviruses can cause more severe diseases, such as the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the global s…
View article: The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type
The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type Open
Magnetic nanoparticles (MNPs) are potential theranostic tools that are biodegraded through different endocytic pathways. However, little is known about the endolysosomal network through which MNPs transit and the influence of the surface c…
View article: Additional file 2 of Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells
Additional file 2 of Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells Open
Additional file 2: The excel file (.xls) shows all the data obtained from this research.
View article: Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas
Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas Open
A critical issue in nanomedicine is to understand the complex dynamics that dictate the interactions of nanoparticles (NPs) with their biological milieu. The most exposed part of a nanoparticle is its surface coating, which comes into cont…
View article: Polymer Nanoparticles for Biomedical Applications
Polymer Nanoparticles for Biomedical Applications Open
The Biomaterials Group (ICTP-CSIC, www.biomateriales.ictp.csic.es) is a multidisciplinary group with two main research lines: the development of new systems for the encapsulation and controlled release of bioactive and therapeutic molecule…
View article: Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone
Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone Open
Polymeric nanoparticles that combine dexamethasone and naproxen reduce inflammation and synergistically inhibit Interleukin-12b (Il12b) transcription in macrophages. This effect can be the result of a cyclooxygenase-dependent or a cyclooxy…
View article: Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of <i>Il12b</i> Transcription in Macrophages
Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of <i>Il12b</i> Transcription in Macrophages Open
Recent studies have demonstrated in vivo synergistic immunosuppressive and anti‐inflammatory capacity of dexamethasone (Dx) and naproxen (NAP) in collagen‐induced arthritis (CIA) rats. However, the molecular basis of this synergistic effec…
View article: Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions
Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions Open
Adoptive cell transfer therapy is currently one of the most promising approaches for cancer treatment. This therapy has some limitations, however, such as the dispersion of in vivo-administered cells, causing only a small proportion to rea…
View article: Flower-like Mn-Doped Magnetic Nanoparticles Functionalized with α<sub><i>v</i></sub>β<sub>3</sub>-Integrin-Ligand to Efficiently Induce Intracellular Heat after Alternating Magnetic Field Exposition, Triggering Glioma Cell Death
Flower-like Mn-Doped Magnetic Nanoparticles Functionalized with α<sub><i>v</i></sub>β<sub>3</sub>-Integrin-Ligand to Efficiently Induce Intracellular Heat after Alternating Magnetic Field Exposition, Triggering Glioma Cell Death Open
Despite the potential of magnetic nanoparticles (NPs) to mediate intracellular hyperthermia when exposed to an alternating magnetic field (AMF), several studies indicate that the intracellular heating capacity of magnetic NPs depends on fa…