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View article: p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer
p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer Open
Breast cancer is the leading cause of death in women under 50. The majority of breast cancers are estrogen receptor α-positive (ER+) and are commonly treated with hormonal therapies such as tamoxifen that inhibit ER activity. The TP53 tumo…
View article: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response Open
Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple tumors is associated with a poor prognosis partly because of the metabolic diversion of cytosolic aspartate for pyrimidine synthesis, supporting prolifer…
View article: p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells
p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells Open
The TP53 gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of normal mammary tissue and breast tumors, undergo transcriptional, metabolic, a…
View article: <scp>TAZ</scp> facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment
<span>TAZ</span> facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment Open
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐containing transcription regulator protein 1 (WWTR1; also known as TAZ)…
View article: Data from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Data from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream…
View article: Data from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Data from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream…
View article: Table S3: Gene Ontology analysis of H1299 RNA-seq from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S3: Gene Ontology analysis of H1299 RNA-seq from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Gene ontology results of either YAP-regulated or TAZ-regulated genes from H1299 RNA-seq analysis, determined by Metascape.
View article: Supplementary Figures file from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Supplementary Figures file from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Supplementary Figures
View article: Table S1: Oligonucleotide sequences from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S1: Oligonucleotide sequences from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Sequences of siRNAs and primers used in this study.
View article: Table S3: Gene Ontology analysis of H1299 RNA-seq from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S3: Gene Ontology analysis of H1299 RNA-seq from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Gene ontology results of either YAP-regulated or TAZ-regulated genes from H1299 RNA-seq analysis, determined by Metascape.
View article: Table S2: List of YAP-differential and TAZ-differential drugs from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S2: List of YAP-differential and TAZ-differential drugs from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
List of 142 YAP-differential drugs and 38 TAZ-differential drugs in LUAD cells. Each row is a drug, and each column specifies additional information, including dose used in the screen, drug targets, indication, clinical phase and the p-val…
View article: Table S4: Gene Ontology analysis of LUAD tumors from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S4: Gene Ontology analysis of LUAD tumors from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Gene Ontology results of either the YAP-correlated or TAZ-correlated genes in LUAD TCGA, determined by Metascape.
View article: Table S4: Gene Ontology analysis of LUAD tumors from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S4: Gene Ontology analysis of LUAD tumors from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Gene Ontology results of either the YAP-correlated or TAZ-correlated genes in LUAD TCGA, determined by Metascape.
View article: Table S2: List of YAP-differential and TAZ-differential drugs from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S2: List of YAP-differential and TAZ-differential drugs from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
List of 142 YAP-differential drugs and 38 TAZ-differential drugs in LUAD cells. Each row is a drug, and each column specifies additional information, including dose used in the screen, drug targets, indication, clinical phase and the p-val…
View article: Table S1: Oligonucleotide sequences from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Table S1: Oligonucleotide sequences from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Sequences of siRNAs and primers used in this study.
View article: Supplementary Figures file from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Supplementary Figures file from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Supplementary Figures
View article: Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients Open
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more…
View article: Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins
Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins Open
Significance Missense mutations in the TP53 gene, encoding the p53 tumor suppressor, are very frequent in human cancer. Some of those mutations, particularly the more common (“hotspot”) ones, not only abrogate p53’s tumor suppressor activi…
View article: Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients Open
Colorectal cancer (CRC) is the third most common cancer worldwide. The TP53 gene is mutated in approximately 60% of all CRC cases. Sporadic CRC is characterized by high prevalence of TP53 hotspot missense mutations. In particular, over 20 …
View article: A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer Open
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream…
View article: Transcriptional profiling reveals a subset of human breast tumors that retain wt <i>TP53</i> but display mutant p53‐associated features
Transcriptional profiling reveals a subset of human breast tumors that retain wt <i>TP53</i> but display mutant p53‐associated features Open
TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), …
View article: Transcriptional profiling reveals a subset of human breast tumors that retain wt<i>TP53</i>but display mutant p53-associated features
Transcriptional profiling reveals a subset of human breast tumors that retain wt<i>TP53</i>but display mutant p53-associated features Open
TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild type (wt) p53 protein, some of them also endow the mutant protein with oncogenic gain-of-function (GOF), facili…
View article: Division of labor between YAP and TAZ in non-small cell lung cancer
Division of labor between YAP and TAZ in non-small cell lung cancer Open
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ, also called WWTR1), the main downstrea…
View article: LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state Open
Deregulated activity of LArge Tumor Suppressor (LATS) tumor suppressors has broad implications on cellular and tissue homeostasis. We examined the consequences of down-regulation of either LATS1 or LATS2 in breast cancer. Consistent with t…
View article: TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma Open
Key Points The HAT complex member TRRAP is vital for maintaining high p53 levels by shielding it against the natural p53 degradation machinery. Acetylation-modifying complexes regulate p53 protein stability, which may provide a basis for t…