Yael Goldfarb
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View article: Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice
Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice Open
Autoimmune regulator (Aire) orchestrates the presentation of self-antigens to developing thymocytes, playing a key role in central tolerance. However, it remains unclear how Aire deficiency influences immune cell development and function. …
View article: A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1
A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1 Open
Autoimmune polyendocrine syndrome type 1 (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene. Most patients present with severe chronic mucocutaneous candidiasis and organ-specific autoimmunity from early childhood, but …
View article: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover Open
Intestinal epithelial cells have the capacity to upregulate MHCII molecules in response to certain epithelial-adhesive microbes, such as segmented filamentous bacteria (SFB). However, the mechanism regulating MHCII expression as well as th…
View article: Epithelial antigen presentation controls commensal-specific intraepithelial T-cells in the gut
Epithelial antigen presentation controls commensal-specific intraepithelial T-cells in the gut Open
Summary The expression of MHCII by intestinal epithelial cells (IEC) determines the severity of intestinal immunopathological reactions. However, the function of MHCII on IEC under homeostatic conditions remains elusive. Here we report tha…
View article: Thymic microfold and endocrine cells regulate thymus homeostasis and self-tolerance
Thymic microfold and endocrine cells regulate thymus homeostasis and self-tolerance Open
Thymic epithelial cells (TEC) play an indispensable role in the development and selection of immunocompetent, yet self-tolerant T cells. To provide further insights into TEC functional and developmental diversity, we utilized multiome anal…
View article: Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation Open
The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engi…
View article: IL18 signaling promotes homing of mature Tregs into the thymus
IL18 signaling promotes homing of mature Tregs into the thymus Open
Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus a…
View article: Author response: IL18 signaling promotes homing of mature Tregs into the thymus
Author response: IL18 signaling promotes homing of mature Tregs into the thymus Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Foxp3+ regulatory T cells (Treg…
View article: AIRE: From promiscuous molecular partnerships to promiscuous gene expression
AIRE: From promiscuous molecular partnerships to promiscuous gene expression Open
Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces promiscuous expression of thousands of tissue‐restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immu…