Yu Xu
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View article: CDKN1A and cellular senescence are associated with immune resistance in advanced lung adenocarcinoma
CDKN1A and cellular senescence are associated with immune resistance in advanced lung adenocarcinoma Open
Cellular senescence is a hallmark of cancer and induces senescence-associated inflammatory responses in the tumor microenvironment (TME). CDKN1A, an important cellular senescence marker, plays significant roles in cell proliferation, invas…
View article: Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas
Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas Open
The Notch pathway regulates the homeostasis and tumorigenesis of gastrointestinal epithelium. Given its roles in cancer stem cell capacity and cancer immunity, we hypothesized that Notch activation can predict poor prognosis and resistance…
View article: Metal-organic framework-based radiosensitizer for cancer therapy
Metal-organic framework-based radiosensitizer for cancer therapy Open
View article: A retrospective study of anti-PD-1 combined with temozolomide adjuvant therapy for stage III resected acral melanoma
A retrospective study of anti-PD-1 combined with temozolomide adjuvant therapy for stage III resected acral melanoma Open
PurposeThis retrospective study was conducted to determine whether the combination of adjuvant anti-PD-1 therapy and temozolomide (TMZ) could improve the disease-free survival (DFS) of patients with resected stage III acral melanoma (AM).M…
View article: Letter to Editor on “Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials”
Letter to Editor on “Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials” Open
View article: Nursing case of necrotizing fasciitis in a patient with hypoproteinemia after spinal tumor resection
Nursing case of necrotizing fasciitis in a patient with hypoproteinemia after spinal tumor resection Open
Objective To summarize the nursing experience of a patient with necrotizing fasciitis (NF) secondary to hypoproteinemia after spinal tumor resection. Methods We analyzed the clinical data of a patient with hypoproteinemia and described in …
View article: A comprehensive pan-cancer analysis of LRFN4: its potential as a prognostic biomarker and therapeutic target for immunotherapy
A comprehensive pan-cancer analysis of LRFN4: its potential as a prognostic biomarker and therapeutic target for immunotherapy Open
Background LRFN4, characterized by leucine-rich repeats and fibronectin type III domains, has been implicated in various human diseases. However, its role in immune regulation and cancer prognosis remains unclear. Methods We performed a co…
View article: Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming
Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming Open
Gefitinib enhances bone fracture healing by modulating lipid metabolism through SOX9, suggesting its potential as a therapeutic agent for improving fracture outcomes.
View article: Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers
Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers Open
Early detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC) and/or hepatitis virus B/C infection (HVI) improves survival, highlighting the need for accurate, affordable diagnostic tools. Here, 11 methylated DNA …
View article: Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second
Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second Open
Imaging flow cytometry (IFC) combines the imaging capabilities of microscopy with the high throughput of flow cytometry, offering a promising solution for high-precision and high-throughput cell analysis in fields such as biomedicine, gree…
View article: [Expert consensus on the diagnosis and treatment of chronic sinusitis in children].
[Expert consensus on the diagnosis and treatment of chronic sinusitis in children]. Open
Objective:Pediatric chronic sinusitis （CRS） is a common disease within the field of otolaryngology-head and neck surgery. Due to the immaturity of sinus development and immune competence in children, its etiology and pathophysiology…
View article: Effects of MDA‐19 on Zebrafish Larval Behavior: Perspectives From Neurodevelopment, Oxidative Stress, and Metabolomics
Effects of MDA‐19 on Zebrafish Larval Behavior: Perspectives From Neurodevelopment, Oxidative Stress, and Metabolomics Open
As global regulations on synthetic cannabinoids tighten, illicit vendors increasingly turn to new structures of synthetic cannabinoids to evade legal scrutiny. MDA‐19, a novel synthetic cannabinoid, exhibited significant agonistic effects …
View article: Risk factors for postoperative hepatic dysfunction in overweight patients with acute type A aortic dissection
Risk factors for postoperative hepatic dysfunction in overweight patients with acute type A aortic dissection Open
View article: Diagnosis of Serous Effusion with Intelligent Imaging Flow Cytometry
Diagnosis of Serous Effusion with Intelligent Imaging Flow Cytometry Open
A serous effusion is a buildup of extra fluid in the serous cavities including pleural, peritoneal, and pericardial cavities. It is important to distinguish benign reactive effusions from effusions caused by malignant proliferation in cyto…
View article: Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2′-guanosine Analogs in Acute T-Lymphoblastic Leukemia
Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2′-guanosine Analogs in Acute T-Lymphoblastic Leukemia Open
(1) Background: The research group has developed a new small molecule, 6-Isopropyldithio-2′-deoxyguanosine analogs-YLS004, which has been shown to be the most sensitive in acute T-lymphoblastic leukemia cells. Moreover, it was found that t…
View article: A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma Open
Chronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflamma…
View article: AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia
AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia Open
In conclusion, our results suggest that long-term metformin treatment could promote ΔFosB degradation and thus attenuate the development of LID through activating the AMPK-mediated autophagy pathway. Overall, our results support the AMPK-m…
View article: Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis
Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis Open
Objective Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the ris…
View article: Unmasking the invisible enemy: A case report of metagenomics-guided diagnosis and treatment of neonatal septic meningitis caused by Corynebacterium aurimucosum in a preterm infant with neonatal lupus erythematosus
Unmasking the invisible enemy: A case report of metagenomics-guided diagnosis and treatment of neonatal septic meningitis caused by Corynebacterium aurimucosum in a preterm infant with neonatal lupus erythematosus Open
Rationale: Neonatal septic meningitis is a serious condition that can be caused by various pathogens, including Corynebacterium aurimucosum , a rare and opportunistic bacterium. We reports a case of infectious meningitis in a premature inf…
View article: Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment
Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment Open
Introduction Individuals with 17-beta-hydroxysteroid dehydrogenase type 3 (17β-HSD3) deficiency face a multitude of challenges, primarily concerning genital appearance, potential malignancy risks, and fertility issues. This study reports o…
View article: The prognostic significance and clinical relevance of stem cell characteristic in bladder cancer
The prognostic significance and clinical relevance of stem cell characteristic in bladder cancer Open
We established a risk classifier based on 16 CSCs-related genes for predicting survival in patients with BLCA. The CSCs-related risk model has both prognostic value and potential predictive value for therapeutic efficacy, which brings us c…
View article: MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis
MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis Open
Maelstrom (MAEL), a novel cancer/testis-associated gene, may facilitate the initiation and progression of human malignancies, warranting comprehensive investigations. Single-cell and tissue-bulk transcriptomic data demonstrat…
View article: UniGS: Unified Representation for Image Generation and Segmentation
UniGS: Unified Representation for Image Generation and Segmentation Open
This paper introduces a novel unified representation of diffusion models for image generation and segmentation. Specifically, we use a colormap to represent entity-level masks, addressing the challenge of varying entity numbers while align…
View article: Intraventricular metastases from small cell lung cancer: case report and literature review
Intraventricular metastases from small cell lung cancer: case report and literature review Open
Background Metastases are uncommon in intraventricular tumors. Intraventricular metastases from lung cancer are extremely rare and present challenges in terms of diagnosis and management. Case Presentation: We present the case of a 52-year…
View article: Hybrid Immuno-RT for Bulky Tumors: Standard Fractionation with Partial Tumor SBRT
Hybrid Immuno-RT for Bulky Tumors: Standard Fractionation with Partial Tumor SBRT Open
View article: Association between baseline C‑reactive protein level and survival outcomes for cancer patients treated with immunotherapy: A meta‑analysis
Association between baseline C‑reactive protein level and survival outcomes for cancer patients treated with immunotherapy: A meta‑analysis Open
The prognostic impact of baseline C-reactive protein (CRP) in patients with cancer receiving immune checkpoint inhibitors (ICIs) is unclear. The present meta-analysis aimed to review the prognostic value of baseline C-reactive protein (CRP…
View article: LAPTM4B-YAP loop feedback amplification enhances the stemness of hepatocellular carcinoma
LAPTM4B-YAP loop feedback amplification enhances the stemness of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is highly heterogeneous, and stemness signatures are frequently elevated in HCC tumor cells to generate heterogeneous subtypes via multidirectional differentiation. However, the mechanisms affecting the regul…
View article: BAP1-related signature predicts benefits from immunotherapy over VEGFR/mTOR inhibitors in ccRCC: a retrospective analysis of JAVELIN Renal 101 and checkmate-009/010/025 trials
BAP1-related signature predicts benefits from immunotherapy over VEGFR/mTOR inhibitors in ccRCC: a retrospective analysis of JAVELIN Renal 101 and checkmate-009/010/025 trials Open
View article: Risk factors for postoperative acute kidney injury in overweight patients with acute type A aortic dissection
Risk factors for postoperative acute kidney injury in overweight patients with acute type A aortic dissection Open
Objective To analyze the clinical characteristics of patients with overweight acute type A aortic dissection, and to explore the risk factors of acute kidney injury in patients with overweight acute type A aortic dissection. Methods From M…
View article: Development and validation of an inflammatory response-related gene and clinical factor-based signature for predicting prognosis in gastric cancer
Development and validation of an inflammatory response-related gene and clinical factor-based signature for predicting prognosis in gastric cancer Open
In GCs, the inflammatory response-related gene-based signature was related to immunotherapy efficacy, and its risk score plus clinical features yielded robust prognostic power. With prospective validation, this model may improve the manage…