Yaghoub Pourshojaei
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View article: Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; an in vitro study
Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; an in vitro study Open
Background and purpose: This study aimed to evaluate the cytotoxicity of synthesized thiosemicarbazone derivatives, particularly on biomarkers associated with ferroptosis. Experimental approach: Thiosemicarbazone derivatives (C1-C5) were s…
View article: Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies
Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies Open
Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. This disease leads to considerable morbidity and mort…
View article: Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer’s disease management; in vitro and in silico study
Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer’s disease management; in vitro and in silico study Open
In this article, we present the design and synthesis of amino-7,8-dihydro-4H-chromenone derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the management of Alzheimer’s disease (AD). The …
View article: Targeting Leishmania with Nitrovinyl Derivatives: Synthesis, in Vitro Assessment, and Computational Exploration
Targeting Leishmania with Nitrovinyl Derivatives: Synthesis, in Vitro Assessment, and Computational Exploration Open
View article: Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies
Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies Open
Background A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole- N -phenylacetamide hybrids 11a–o was designed based on molecular hybridization of the active pharmacophores of the potent α-glucosidase inhibitors. These compounds we…
View article: Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: Design, synthesis, in vitro α-glucosidase inhibition, and computational studies
Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: Design, synthesis, in vitro α-glucosidase inhibition, and computational studies Open
Background A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole- N -phenylacetamide hybrids 11a-o was designed based on molecular hybridization of the active pharmacophores of the potent α-glucosidase inhibitors. These compounds we…
View article: Synthesis, Molecular Docking Study and Evaluation of Cytotoxic Activity of Two Homoisoflavonoids Containing Morpholinoethoxy Substitution
Synthesis, Molecular Docking Study and Evaluation of Cytotoxic Activity of Two Homoisoflavonoids Containing Morpholinoethoxy Substitution Open
Synthesis, Molecular Docking Study and Evaluation of Cytotoxic Activity of Two Homoisoflavonoids Containing Morpholinoethoxy Substitution
View article: Synthesis of some benzylidene thiosemicarbazide derivatives and evaluation of their cytotoxicity on U87, MCF-7, A549, 3T3 and HUVEC cell lines
Synthesis of some benzylidene thiosemicarbazide derivatives and evaluation of their cytotoxicity on U87, MCF-7, A549, 3T3 and HUVEC cell lines Open
Iron homeostasis is altered in tumours in response to a perturbation in the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable to iron deficiency. Compounds having thiosemicarbazide scaffo…
View article: Synthesis and identification of meta-(4-bromobenzyloxy) benzaldehyde thiosemicarbazone (MBBOTSC) as novel ligand for cadmium extraction by ultrasound assisted-dispersive-ionic liquid-liquid micro extraction method
Synthesis and identification of meta-(4-bromobenzyloxy) benzaldehyde thiosemicarbazone (MBBOTSC) as novel ligand for cadmium extraction by ultrasound assisted-dispersive-ionic liquid-liquid micro extraction method Open
In this research, meta-(4-bromobenzyloxy) benzaldehyde thiosemicarbazone (MBBOTSC) as a novel ligand was synthesized from the reaction between meta-(4-bromobenzyloxy) benzaldehyde and thiosemicarbazide under basic condition in water and et…
View article: Developing a magnetic nanocomposite adsorbent based on carbon quantum dots prepared from Pomegranate peel for the removal of Pb(II) and Cd(II) ions from aqueous solution
Developing a magnetic nanocomposite adsorbent based on carbon quantum dots prepared from Pomegranate peel for the removal of Pb(II) and Cd(II) ions from aqueous solution Open
Agriculture waste is a good choice for the production of carbon dots owing to its abundance, wide availability, eco-friendly nature. In this study a novel magnetic bioadsorbent based on carbon quantum dots (Fe3O4-PPCQDs) from Pomegranate p…
View article: Cobalt separation from water and food samples based on penicillamine ionic liquid and dispersive liquid-liquid microextraction before determination by AT-FAAS
Cobalt separation from water and food samples based on penicillamine ionic liquid and dispersive liquid-liquid microextraction before determination by AT-FAAS Open
The cobalt compounds have adverse health effect on human and caused damage to the DNA cells, neurological and endocrine systems. Therefore, the separation and determination of cobalt in water and food samples must be considered. In this re…
View article: <p>Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines</p>
Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines Open
It could be concluded that the new synthesized structure could transfer a high amount of the therapeutic agent into cells with best activity.
View article: Phenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design
Phenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design Open
View article: Synthesis, and molecular modeling of bis(3-(piperazine-1-yl)propyl)tungstate (BPPT) nanoparticles, and its first catalytic application for one-pot synthesis of 4H-chromene derivatives
Synthesis, and molecular modeling of bis(3-(piperazine-1-yl)propyl)tungstate (BPPT) nanoparticles, and its first catalytic application for one-pot synthesis of 4H-chromene derivatives Open
View article: Delayed death following paraquat poisoning: three case reports and a literature review
Delayed death following paraquat poisoning: three case reports and a literature review Open
Paraquat (PQ) poisoning is principally reported in developing countries. However, most fatalities occur elsewhere due to the induction of multi-organ failure. PQ poisoning can hardly be managed by clinical practice, and no specific antidot…
View article: Synthesis and Biological Evaluation of 4-hydroxychromenyl arylmethyl-6-hydroxy pyrimidine-2, 4-dione Derivatives
Synthesis and Biological Evaluation of 4-hydroxychromenyl arylmethyl-6-hydroxy pyrimidine-2, 4-dione Derivatives Open
Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4…
View article: Ultrasound-assisted and Efficient Knoevenagel Condensation Reaction Catalyzed by Silica Sodium Carbonate Nanoparticles
Ultrasound-assisted and Efficient Knoevenagel Condensation Reaction Catalyzed by Silica Sodium Carbonate Nanoparticles Open
An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano-or ethylciano acetates in a onepot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described.In this reaction, SSC…
View article: A short synthesis of 7-amino alkoxy homoisoflavonoides
A short synthesis of 7-amino alkoxy homoisoflavonoides Open
The synthesis of novel derivatives of homoisoflavonoids as potentially interesting medicinally important heterocycles in an efficient catalytic alternative two-step route has been introduced.
View article: Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain Open
View article: Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors
Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors Open
A series of coumarin–resveratrol hybrids, 3-arylcoumarin derivatives 3a–u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octan…