Yousheng Mao
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View article: Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression
Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression Open
The prognosis of early-stage lung adenocarcinoma (LUAD) worsens significantly during the progression from adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) to invasive adenocarcinoma (IAC), emphasizing the importance of un…
View article: Diagnostic and Predictive Value of CD133‐Positive Circulating Tumor Cells as an Indicator of Pathological High‐Risk Factors for Stage I Non‐Small Cell Lung Cancer
Diagnostic and Predictive Value of CD133‐Positive Circulating Tumor Cells as an Indicator of Pathological High‐Risk Factors for Stage I Non‐Small Cell Lung Cancer Open
Background The noninvasive prediction of pathological high‐risk factors in stage I NSCLC patients before surgery remains an area for further investigation, and circulating stem cancer cells are a potential predictive diagnostic indicator. …
View article: The value of relative CT attenuation in predicting invasiveness in patients with T1-stage lung adenocarcinoma
The value of relative CT attenuation in predicting invasiveness in patients with T1-stage lung adenocarcinoma Open
In T1-stage LUAD, both lobe-normalized relative CT attenuation and nodule-specific absolute CT attenuation provide reliable predictors of invasiveness. However, relative CT values did not outperform absolute CT values in this study. Thus, …
View article: The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles
The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles Open
Background The gut microbiota plays a key role in regulating bone homeostasis. Our previous work demonstrated that the novel organic selenium compound β-trifluoroethoxy dimethyl selenide (4aa alleviates osteoporosis; however, its mechanism…
View article: RETRACTED: Depression Mediates the Association Between Ambient Air Pollution and Gastrointestinal/Liver Diseases: A Nationwide Cohort Study in China
RETRACTED: Depression Mediates the Association Between Ambient Air Pollution and Gastrointestinal/Liver Diseases: A Nationwide Cohort Study in China Open
The authors have requested that this preprint be removed from Research Square.
View article: PSENEN mutation in a Chinese family manifesting as concurrent hidradenitis suppurativa and Dowling-Degos disease: a case report of four generations
PSENEN mutation in a Chinese family manifesting as concurrent hidradenitis suppurativa and Dowling-Degos disease: a case report of four generations Open
Hidradenitis suppurativa and Dowling-Degos disease are two independent rare diseases with characteristic clinical manifestations. The PSENEN gene encodes a critical subunit of the γ -secretase complex, mutations of which can independently …
View article: 3D computed tomography density of stage T1 lung cancer, which value is most stable for predicting its invasiveness?
3D computed tomography density of stage T1 lung cancer, which value is most stable for predicting its invasiveness? Open
The 90th percentile of CT values reliably predicts invasiveness in stage T1 lung adenocarcinoma. This finding facilitates the clinical assessment of its invasiveness, enabling a better grasp of the timing of clinical intervention and the f…
View article: Identification of characteristic genes in cutaneous squamous cell carcinoma based on weighted gene co-expression network analysis
Identification of characteristic genes in cutaneous squamous cell carcinoma based on weighted gene co-expression network analysis Open
Objective This study aims to identify characteristic genes associated with cutaneous squamous cell carcinoma (cSCC). Methods Differentially expressed genes (DEGs) and hub genes in key module were identified using the limma package and weig…
View article: Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)
Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review) Open
Psoriasis is a chronic systemic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and significant immune dysregulation. Obesity is markedly associated with psoriasis, acting as an independent risk factor that …
View article: Shifting landscapes of gender equity in oncology journals: a decade of authorship trends
Shifting landscapes of gender equity in oncology journals: a decade of authorship trends Open
Although female authorship in oncology journals has increased over the past decade, disparities remain, particularly in senior roles and citation impact. Addressing these issues requires targeted strategies, including mentorship programs, …
View article: Integrated analysis of genetic, proteinic, and metabolomic alterations in Behcet’s disease
Integrated analysis of genetic, proteinic, and metabolomic alterations in Behcet’s disease Open
Numerous studies have investigated the alterations of genes, proteins, and metabolites in Behcet's disease (BD). By far, little is known about the depiction of panoramic changes underlying this disease. This study purposed to assess the co…
View article: Three-field vs two-field lymphadenectomy in thoracic ESCC patients: a multicenter randomized study (NST 1503)
Three-field vs two-field lymphadenectomy in thoracic ESCC patients: a multicenter randomized study (NST 1503) Open
Additional cervical lymphadenectomy can be avoided in the patients with middle or lower thoracic ESCC and negative RRLN-LNs by frozen section treated by upfront surgery.Trial Registration: ClinicalTrials.gov Identifier NCT02448953.
View article: Lung Cancer Associated with Cystic Airspaces: Current Insights into Diagnosis, Pathophysiology, and Treatment Strategies
Lung Cancer Associated with Cystic Airspaces: Current Insights into Diagnosis, Pathophysiology, and Treatment Strategies Open
Lung cancer associated with cystic airspaces (LCCA) is a rare subtype of non-small-cell lung cancer (NSCLC), accounting for 1–4% of cases. LCCA is characterized by the presence of cystic airspaces within or at the periphery of the tumor on…
View article: Quantitative analysis of imaging characteristics in lung adenocarcinoma in situ using artificial intelligence
Quantitative analysis of imaging characteristics in lung adenocarcinoma in situ using artificial intelligence Open
Background With the rising incidence of pulmonary nodules (PNs), lung adenocarcinoma in situ (AIS) is a critical early stage of lung cancer, necessitating accurate diagnosis for early intervention. This study applies artificial intelligenc…
View article: Patient-reported outcomes in lung cancer surgery: A narrative review
Patient-reported outcomes in lung cancer surgery: A narrative review Open
Lung cancer is a leading cause of cancer-related mortality worldwide, profoundly affecting patients' quality of life. Patient-reported outcomes (PROs) provide essential insights from the patients' perspective, a crucial aspect often overlo…
View article: Changes in the recent three decades and survey on the current status of surgical treatment for esophageal cancer in China
Changes in the recent three decades and survey on the current status of surgical treatment for esophageal cancer in China Open
Background To review the changes and survey on status quo of the surgical treatment for esophageal cancer in China. The differences in diagnosis and treatment for esophageal cancer among hospitals in different regions across China were als…
View article: The impact of the COVID-19 pandemic on the diagnosis, treatment, and outcomes of lung cancer: A nationwide study
The impact of the COVID-19 pandemic on the diagnosis, treatment, and outcomes of lung cancer: A nationwide study Open
The COVID-19 pandemic disrupted healthcare systems globally, significantly impacting the continuum of care for diseases such as lung cancer (LC), which is the deadliest cancer worldwide. Preliminary evidence suggests shifts toward more adv…
View article: Investigating the determinants of fear of cancer recurrence in patients with early‐stage non‐small cell lung cancer: Insights from a restricted cubic spline model
Investigating the determinants of fear of cancer recurrence in patients with early‐stage non‐small cell lung cancer: Insights from a restricted cubic spline model Open
Objective This study aims to investigate the determinants and the dose–response relationship of fear of cancer recurrence among patients with early‐stage non‐small cell lung cancer (NSCLC), aiming to inform prevention and intervention stra…
View article: The impact of open access on citations, Pageviews, and downloads: a scientometric analysis in <i>Postgraduate Medical Journal</i>
The impact of open access on citations, Pageviews, and downloads: a scientometric analysis in <i>Postgraduate Medical Journal</i> Open
Purpose The influence of Open Access (OA) on the citation impact of scholarly articles remains a topic of considerable debate. This study aims to elucidate the relationship between OA publication and citation metrics, as well as article vi…
View article: Proposed novel grading system for stage I invasive lung adenocarcinoma and a comparison with the 2020 <scp>IASLC</scp> grading system
Proposed novel grading system for stage I invasive lung adenocarcinoma and a comparison with the 2020 <span>IASLC</span> grading system Open
Background Several studies have proposed grading systems for risk stratification of early‐stage lung adenocarcinoma based on histological patterns. However, the reproducibility of these systems is poor in clinical practice, indicating the …
View article: Screening microRNAs as potential prognostic biomarkers for lung adenocarcinoma
Screening microRNAs as potential prognostic biomarkers for lung adenocarcinoma Open
miRNAs associated with the prognosis of patients with stage I LUAD were screened and validated, and a risk model for predicting the prognosis of patients was constructed. This model has good consistency with the actual prognosis of patient…