Yahya I. Asiri
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View article: Cyanobacteria-Derived Extracellular Vesicles: A Novel Frontier in Drug Delivery and Therapeutics
Cyanobacteria-Derived Extracellular Vesicles: A Novel Frontier in Drug Delivery and Therapeutics Open
Cyanobacteria, known for their diverse and potent bioactive compounds, present a unique method for drug delivery via their extracellular vesicles (EVs), often described as exosome-like due to size and function but distinct in biogenesis. T…
View article: Targeting EGFR by newer 4,6-Bis(( <i>E</i> )-4-hydroxy-3-methoxystyryl)-1-(aryl)pyrimidin-2(1 <i>H</i> )-one analogues as antiproliferative agents: eco-friendly chemical modification, <i>in-vitr</i> o and <i>in-silico</i> studies
Targeting EGFR by newer 4,6-Bis(( <i>E</i> )-4-hydroxy-3-methoxystyryl)-1-(aryl)pyrimidin-2(1 <i>H</i> )-one analogues as antiproliferative agents: eco-friendly chemical modification, <i>in-vitr</i> o and <i>in-silico</i> studies Open
We reported herein the synthesis, antiproliferative activity and in-silico studies of semi-synthetic curcumin analogues. An equimolar amount of curcumin (A1) and mono aryl urea (B01–B04) were heated in a glycerol-water (1:2, v/v) solvent s…
View article: Public Awareness and Knowledge of Prostate Cancer Screening: A Community Study in Saudi Arabia
Public Awareness and Knowledge of Prostate Cancer Screening: A Community Study in Saudi Arabia Open
Background: Prostate cancer (PCa) is one of the most common malignancies among men in Saudi Arabia and contributes significantly to cancer-related morbidity and mortality. The objective of this survey was to evaluate community awareness an…
View article: Wound-Healing Potential of Myristica fragrans Essential Oil: A Multi-Targeted Approach Involving Inflammation, Oxidative Stress, and Apoptosis Regulation
Wound-Healing Potential of Myristica fragrans Essential Oil: A Multi-Targeted Approach Involving Inflammation, Oxidative Stress, and Apoptosis Regulation Open
Background: Essential oils are widely studied for their therapeutic potential, including their role in wound healing. Myristica fragrans essential oil (MEO) has been previously investigated for various pharmacological activities, including…
View article: Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy
Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy Open
Background/Objectives: Gouty arthritis (GA) is a chronic inflammatory condition characterized by hyperuricemia and NLRP3 inflammasome activation, leading to joint damage and systemic inflammation. Although allopurinol (ALP), a xanthine oxi…
View article: Design, synthesis and in silico molecular modelling studies of 2-Hydrazineyl-2-oxoethyl-4-(1H-pyrrol-1-yb) benzoate derivatives: a potent dual DHFR and ENR-reductase inhibitors with antitubercular, antibacterial and cytotoxic potential
Design, synthesis and in silico molecular modelling studies of 2-Hydrazineyl-2-oxoethyl-4-(1H-pyrrol-1-yb) benzoate derivatives: a potent dual DHFR and ENR-reductase inhibitors with antitubercular, antibacterial and cytotoxic potential Open
The current research includes the study of 28 new 2-hydrazineyl-2-oxoethyl-4-(1 H -pyrrol-1-yl) benzoate derivatives as antitubercular, antibacterial, and enoyl-ACP reductase enzyme inhibitors. SYBYL-X.2.0 was used to investigate the molec…
View article: Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation
Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation Open
The spreading of COVID-19 has posed a risk to global health, especially for lung cancer patients. An investigation is needed to overcome the challenges of COVID-19 pathophysiology and lung cancer disease. This study was designed to evaluat…
View article: Cardioprotective, Lipid-Lowering And Glucose-Lowering Properties Of Edible Seeds From The Cucurbitaceae Family
Cardioprotective, Lipid-Lowering And Glucose-Lowering Properties Of Edible Seeds From The Cucurbitaceae Family Open
Diabetes mellitus impairs carbohydrate, protein, and lipid metabolism, increasing the risk of metabolic dysfunction and associated complications. This study aimed to evaluate the glucose-lowering and cardioprotective effects of selected ed…
View article: The Role of Team Synergy in Infection Control: A Systematic Review of Healthcare Collaboration
The Role of Team Synergy in Infection Control: A Systematic Review of Healthcare Collaboration Open
Background: Infection control is a critical component of patient safety in healthcare settings, requiring coordinated efforts among medical staff. Effective collaboration and synergy among healthcare professionals, including physicians, nu…
View article: Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings
Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings Open
Despite major advancements in our understanding of its fundamental causes, pain—both acute and chronic—remains a serious health concern. Various preclinical investigations utilizing diverse animal, cellular, and alternative models are requ…
View article: Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds Open
ASEE could be useful in the treatment of human triple-negative breast cancer without any safety risks.
View article: Development and Optimization of Proniosomal Formulation of Irbesartan Using a Box–Behnken Design to Enhance Oral Bioavailability: Physicochemical Characterization and <i>In Vivo</i> Assessment
Development and Optimization of Proniosomal Formulation of Irbesartan Using a Box–Behnken Design to Enhance Oral Bioavailability: Physicochemical Characterization and <i>In Vivo</i> Assessment Open
This research work aimed to develop and evaluate proniosomes for the oral delivery of the lipophilic drug Irbesartan (IRB) to improve its solubility and bioavailability. Proniosomes of Irbesartan were formulated using a lipid, surfactant, …
View article: Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations
Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations Open
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objecti…
View article: Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments
Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments Open
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objecti…
View article: An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent
An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent Open
Tamanu oil has traditionally been used to treat various skin problems. The oil has wound-healing and skin-regenerating capabilities and encourages the growth of new skin cells, all of which are helpful for fading scars and hyperpigmentatio…
View article: Investigation of the linear and nonlinear optical properties in the crystalline phase of a pyrimidine derivative—a potential nonlinear optical material: analysis of its structure, reactivity, and docking studies
Investigation of the linear and nonlinear optical properties in the crystalline phase of a pyrimidine derivative—a potential nonlinear optical material: analysis of its structure, reactivity, and docking studies Open
In this study, we examined the nonlinear optical properties of a pyrimidine derivative in its crystalline phase using an iterative electrostatic method (IEM) to explore its potential applications in developing new nonlinear optical materia…
View article: Utilizing information technology and mobile health applications to improve drug-drug interaction awareness in Saudi Arabia
Utilizing information technology and mobile health applications to improve drug-drug interaction awareness in Saudi Arabia Open
Information technology and mobile health (mHealth) applications play a significant role in the healthcare sector of Saudi Arabia.Drug-drug interaction (DDI) awareness is crucial to the patient safety.This study aims to explore the role of …
View article: Phytocompound screening, antioxidant activity and molecular docking studies of pomegranate seed: a preventive approach for SARS-CoV-2 pathogenesis
Phytocompound screening, antioxidant activity and molecular docking studies of pomegranate seed: a preventive approach for SARS-CoV-2 pathogenesis Open
A global hazard to public health has been generated by the coronavirus infection 2019 (COVID-19), which is spreading quickly. Pomegranate is a strong source of antioxidants and has demonstrated a number of pharmacological characteristics. …
View article: Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ-Induced Kindled Epilepsy in Rats: In Vivo and In Silico
Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ-Induced Kindled Epilepsy in Rats: In Vivo and In Silico Open
The ameliorative effect of ethanolic extract of M. oleifera (MOEE) leaves in combination with curcumin against seizures, cognitive impairment, and oxidative stress in the molecular docking of PTZ-induced kindled rats was performed to predi…
View article: Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction
Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction Open
Oral phosphodiesterase inhibitors have emerged as a game changer for the treatment of erectile dysfunction (ED) since attaining FDA approval for its first member, sildenafil, in 1998. Topical penile therapy could be a viable replacement fo…
View article: An overview of ion channels therapeutics in the treatment of pain
An overview of ion channels therapeutics in the treatment of pain Open
Significance of the study: The clinical management of severe and chronic pain relies heavily on opioids that cause serious side-effects. There therefore exists an urgent need to develop safer and effective analgesics. Moreover, there has b…
View article: Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ Induced Kindled Epilepsy in rats; In Vivo and In Silico Study
Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ Induced Kindled Epilepsy in rats; In Vivo and In Silico Study Open
The ameliorative effect ethanolic extract of M. oleifera (MO) leaves in combination of curcumin against seizures, cognitive impairment & oxidative stress PTZ-induced kindled rats. Molecular docking was performed to predict the potentia…
View article: Effects of bioactive compound, Ginsenoside Rb1 on Burn Wounds Healing In Diabetic Rats: Influencing M1 To M2 Phenotypic Trans
Effects of bioactive compound, Ginsenoside Rb1 on Burn Wounds Healing In Diabetic Rats: Influencing M1 To M2 Phenotypic Trans Open
Panax notoginseng (P.notoginseng) has been used traditionally to treat traumatic injuries.Ginsenoside Rb1, a key active ingredient derived from Panax notoginseng, has received a lot of interest due to its anti-inflammatory, bacteriostatic,…
View article: Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies
Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies Open
The most catastrophic problem that affects living standards is viral infections.This work aims to discover and evaluate new antiviral agents from marine sources.Antiviral activities of n-hexane, dichloromethane, ethyl acetate, and butanol …
View article: A Box–Behnken Extraction Design and Hepatoprotective Effect of Isolated Eupalitin-3-O-β-D-Galactopyranoside from Boerhavia diffusa Linn.
A Box–Behnken Extraction Design and Hepatoprotective Effect of Isolated Eupalitin-3-O-β-D-Galactopyranoside from Boerhavia diffusa Linn. Open
The objectives of this study were to optimize and quantify the maximum percentage yield of eupalitin-3-O-β-D-galactopyranosidefrom Boerhavia diffusa leaves using response surface methodology (RSM), as well as to demonstrate the hepatoprote…
View article: CCDC 1935074: Experimental Crystal Structure Determination
CCDC 1935074: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Strong Selectional Forces Fine-Tune CpG Content in Genes Involved in Neurological Disorders as Revealed by Codon Usage Patterns
Strong Selectional Forces Fine-Tune CpG Content in Genes Involved in Neurological Disorders as Revealed by Codon Usage Patterns Open
Neurodegenerative disorders cause irreversible damage to the neurons and adversely affect the quality of life. Protein misfolding and their aggregation in specific parts of the brain, mitochondrial dysfunction, calcium load, proteolytic st…
View article: In-situ manipulation of gel layer fouling into gel layer membrane formation on porous supports for water treatment
In-situ manipulation of gel layer fouling into gel layer membrane formation on porous supports for water treatment Open
The inaccessibility of clean water is one of the growing issues of this era. Indeed, cost-effective and sustainable methods for recycling wastewater are essential. Although membrane separation is an efficient technology for the recycling a…