Yahya Cheema
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View article: AAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthma
AAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthma Open
The main structural components of mucus produced in the lung are mucin 5B (MUC5B) and mucin 5AC (MUC5AC) where a relatively higher expression of MUC5B is typical in health. In the lungs of individuals with asthma, there is a shift from MUC…
View article: Barrier Function of the Extracellular Matrix in AAV Gene Therapy
Barrier Function of the Extracellular Matrix in AAV Gene Therapy Open
Purpose: The extracellular matrix (ECM) is a major component of the tissue microenvironment which may pose a barrier to the distribution of AAV in target organs, preventing delivery of therapeutic cargo. We sought to address this potential…
View article: Synthetic mucus barrier arrays as a nanoparticle formulation screening platform
Synthetic mucus barrier arrays as a nanoparticle formulation screening platform Open
Synthetic mucus barrier arrays are developed as a high-throughput screening platform for nanoparticle drug delivery applications.
View article: Synthetic mucus barrier arrays as a nanoparticle formulation screening platform
Synthetic mucus barrier arrays as a nanoparticle formulation screening platform Open
A mucus gel layer lines the luminal surface of tissues throughout the body to protect them from infectious agents and particulates. As a result, nanoparticle drug delivery systems delivered to these sites may become trapped in mucus and su…
View article: Shaping nanoparticle diffusion through biological barriers to drug delivery
Shaping nanoparticle diffusion through biological barriers to drug delivery Open
Nanoparticle drug delivery systems encounter many biological barriers, such as the extracellular matrix and mucus gels, that they must bypass to gain access to target cells. A design parameter that has recently gained attention is nanopart…
View article: Shaping nanoparticle diffusion through biological barriers to drug delivery
Shaping nanoparticle diffusion through biological barriers to drug delivery Open
Nanoparticle drug delivery systems encounter many biological barriers, such as the extracellular matrix and mucus gels, that they must bypass to gain access to target cells. A design parameter that has recently gained attention is nanopart…
View article: Utilizing Low Temperatures to Reduce Deformation in 3D Printed Hydrogel Lattices
Utilizing Low Temperatures to Reduce Deformation in 3D Printed Hydrogel Lattices Open
View article: Systematic Evaluation of Light-Activatable Biohybrids for Anti-Glioma Photodynamic Therapy
Systematic Evaluation of Light-Activatable Biohybrids for Anti-Glioma Photodynamic Therapy Open
Photosensitizing biomolecules (PSBM) represent a new generation of light-absorbing compounds with improved optical and physicochemical properties for biomedical applications. Despite numerous advances in lipid-, polymer-, and protein-based…
View article: Utilization of cryogenic temperatures to reduce line width variability in 3D bioprinted hydrogel lattices
Utilization of cryogenic temperatures to reduce line width variability in 3D bioprinted hydrogel lattices Open
The 3D bioprinting of acellular hydrogel scaffolds holds enormous potential for wound healing and the regeneration of tissue. The precision of hydrogel scaffolds is limited by the diffusion and fusion of soft hydrogels during the printing …