Yahya F. Jamous
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View article: Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions
Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions Open
Antimicrobial resistance (AMR) is a present, pressing global public health crisis associated with rising morbidity and mortality rates due to previously curable infectious disease. Targeted drug delivery is an important approach to address…
View article: Prevalence and Impact of Antidepressant and Anti-Anxiety Use Among Saudi Medical Students: A National Cross-Sectional Study
Prevalence and Impact of Antidepressant and Anti-Anxiety Use Among Saudi Medical Students: A National Cross-Sectional Study Open
Background: Mental health issues among medical students have gained increasing attention globally, with studies indicating a high prevalence of psychological disorders within this population. The use of antidepressants and anti-anxiety med…
View article: Investigation of illicit pregabalin in seized samples from Saudi Arabia
Investigation of illicit pregabalin in seized samples from Saudi Arabia Open
Introduction Pregabalin (PGL) is a medication that is prescribed for controlling specific neurological-related symptoms. Due to its abuse in multiple countries, PGL has been classified as a controlled substance by authorities, including th…
View article: Nanoparticles for Cancer Immunotherapy: Innovations and Challenges
Nanoparticles for Cancer Immunotherapy: Innovations and Challenges Open
Cancer treatment has undergone a paradigm shift following the introduction of novel cancer treatment approaches that involve the host’s immune system in fighting established tumors. This new concept aids the immune system in identifying, a…
View article: Association of Vitamin D Serum Levels With Glycemic, Lipid Profiles, and Diabetic Complications in Saudi Type II Diabetes Patients
Association of Vitamin D Serum Levels With Glycemic, Lipid Profiles, and Diabetic Complications in Saudi Type II Diabetes Patients Open
View article: Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency
Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency Open
Methotrexate (MTX) is classified as an antimetabolite. It’s commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity. The tricky move is to investigate th…
View article: Nephro- and Cardiotoxic Effects of Etoricoxib: Insights into Arachidonic Acid Metabolism and Beta-Adrenergic Receptor Expression in Experimental Mice
Nephro- and Cardiotoxic Effects of Etoricoxib: Insights into Arachidonic Acid Metabolism and Beta-Adrenergic Receptor Expression in Experimental Mice Open
Background: Etoricoxib is a widely used anti-inflammatory drug, but its safety profile concerning cardiovascular and renal health remains inadequately explored. This study aimed to assess the nephro- and cardiotoxic effects of etoricoxib i…
View article: The Impact of COVID-19 Vaccination Side-Effects on Work Attendance among Saudi Healthcare Workers
The Impact of COVID-19 Vaccination Side-Effects on Work Attendance among Saudi Healthcare Workers Open
Objective: This cross-sectional-survey-based study aimed to investigate the severity of side-effects from Coronavirus disease (COVID-19) mRNA (Pfizer, Moderna), viral vector DNA (Oxford-AstraZeneca, J&J/Janssen), inactivated virus (Sinopha…
View article: Antimicrobial Nanoemulsion: A futuristic approach in antibacterial drug delivery system
Antimicrobial Nanoemulsion: A futuristic approach in antibacterial drug delivery system Open
Complex, kinetically stable emulsions with an average droplet size of 50–100 nm and a mean droplet diameter of 50–1000 nm is known as nanoemulsions. They are often referred to as tiny submicron, ultrafine, or finely dispersed emulsions; th…
View article: mRNA Vaccines: from a weak tool to a leading technology to fight COVID-19 by Yahya Fahad Jamous
mRNA Vaccines: from a weak tool to a leading technology to fight COVID-19 by Yahya Fahad Jamous Open
In recent years, mRNA-vaccine technology has seen significant advances in the prophylaxis against many diseases. Today, after the emergence of COVID-19 and the use of mRNA vaccines as prophylactic vaccines to prevent the spread of the dise…
View article: A Current Landscape on Alport Syndrome Cases: Characterization, Therapy and Management Perspectives
A Current Landscape on Alport Syndrome Cases: Characterization, Therapy and Management Perspectives Open
Alport syndrome (AS) is a rare genetic disorder categorized by the progressive loss of kidney function, sensorineural hearing loss and eye abnormalities. It occurs due to mutations in three genes that encode for the alpha chains of type IV…
View article: The Safety and Effectiveness of mRNA Vaccines Against SARS-CoV-2
The Safety and Effectiveness of mRNA Vaccines Against SARS-CoV-2 Open
The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in numerous deaths worldwide, along with devastating economic disruptions, and has posed unpre…
View article: Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage
Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage Open
Tuberculosis is a disease of poverty, discrimination, and socioeconomic burden. Epidemiological studies suggest that the mortality and incidence of tuberculosis are unacceptably higher worldwide. Genomic mutations in embCAB, embR, katG, in…
View article: Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids
Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids Open
Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk factors including hormones like insulin and insulin like growth factors (e.g., IGF-1) have been considered responsible for growth and progression of…
View article: The Incidence and Severity of COVID-19 Infection Post Vaccination in Saudi Arabia
The Incidence and Severity of COVID-19 Infection Post Vaccination in Saudi Arabia Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Presently, there is ongoing continuous research for more therapeutic options with a wide variety of vacc…
View article: Reviewing the Prospective Pharmacological Potential of Isothiocyanates in Fight against Female-Specific Cancers
Reviewing the Prospective Pharmacological Potential of Isothiocyanates in Fight against Female-Specific Cancers Open
Gynecological cancers are the most commonly diagnosed malignancies in females worldwide. Despite the advancement of diagnostic tools as well as the availability of various therapeutic interventions, the incidence and mortality of female-sp…
View article: Crinum latifolium mediated biosynthesis of gold nanoparticles and their anticandidal, antibiofilm and antivirulence activity
Crinum latifolium mediated biosynthesis of gold nanoparticles and their anticandidal, antibiofilm and antivirulence activity Open
Candida spp. is one of the most common opportunistic human fungal pathogens, responsible for 90–100% of mucosal infections. Germ tube formation, hyphal morphogenesis, the production of tissue-damaging extracellular enzymes, and drug-resist…
View article: Investigation of the Protective Effects of Urtica dioica, Capsella bursa-pastoris and Inula racemosa on Acetaminophen-Induced Nephrotoxicity in Swiss Albino Male Mice
Investigation of the Protective Effects of Urtica dioica, Capsella bursa-pastoris and Inula racemosa on Acetaminophen-Induced Nephrotoxicity in Swiss Albino Male Mice Open
Acetaminophen (APAP) is the most commonly used nonprescription antipyretic-analgesic drug. This medication is thought to be safe at the suggested dosage (4 g/24 h), but its overdose (up to 2.5 g/kg) can cause severe injuries to the human b…
View article: Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor
Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor Open
Around the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6–20% of females. Our study’s major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabo…
View article: Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms
Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms Open
Major epigenetic alterations, such as chromatin modifications, DNA methylation, and miRNA regulation, have gained greater attention and play significant roles in oncogenesis, representing a new paradigm in our understanding of cancer susce…
View article: Bioinspired ferromagnetic CoFe<sub>2</sub>O<sub>4</sub> nanoparticles: Potential pharmaceutical and medical applications
Bioinspired ferromagnetic CoFe<sub>2</sub>O<sub>4</sub> nanoparticles: Potential pharmaceutical and medical applications Open
The primary goal of this work was to develop a cost-effective, non-toxic, eco-friendly, and simple approach for the green synthesis of CoFe 2 O 4 nanoparticles (NPs) using Aloe vera leaf extract by the sol–gel auto-combustion method. In or…
View article: Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review
Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review Open
Phytochemicals possess various intriguing pharmacological properties against diverse pathological conditions. Extensive studies are on-going to understand the structural/functional properties of phytochemicals as well as the molecular mech…
View article: Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells
Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells Open
Natural antioxidants derived from plants have played a vital role in preventing a wide range of human chronic conditions and provide novel bioactive leads for investigators in pharmacotherapy discovery. This work was designed to examine th…
View article: Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster
Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster Open
Plant fractions have a diversity of biomolecules that can be used to make complicated reactions for the bioactive fabrication of metal nanoparticles (NPs), in addition to being beneficial as antioxidant medications or dietary supplements. …
View article: Cytological Changes and Immunocytochemistry Expression of P53 in Oral Mucosa Among Waterpipe Users in the Kingdom of Saudi Arabia
Cytological Changes and Immunocytochemistry Expression of P53 in Oral Mucosa Among Waterpipe Users in the Kingdom of Saudi Arabia Open
Objective In this study, we aimed to assess cytological changes and p53 expression in oral mucosa among waterpipe users in the Kingdom of Saudi Arabia (KSA). Methodology A case-control study was conducted in KSA from January to October 202…
View article: Identification of SCD1 as a heart failure-promoting gene by whole genome microarray gene expression profiling and transgenic techniques
Identification of SCD1 as a heart failure-promoting gene by whole genome microarray gene expression profiling and transgenic techniques Open
View article: Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor
Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor Open
Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of atherosclerosis, we investigated the impact of the B2 bradykinin receptor, Bdkrb2, on…