Yajun Deng
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View article: Immunomodulatory polysaccharide from <em>Lactobacillus paracasei</em> VL8 enhances immunity by modulating gut microbiota in immunosuppressed mice
Immunomodulatory polysaccharide from <em>Lactobacillus paracasei</em> VL8 enhances immunity by modulating gut microbiota in immunosuppressed mice Open
View article: Influence of illness perception on depression and anxiety in individuals with schizophrenia during the COVID-19 pandemic
Influence of illness perception on depression and anxiety in individuals with schizophrenia during the COVID-19 pandemic Open
Objective This study aimed to investigate the factors influencing depression and anxiety in individuals with schizophrenia during the COVID-19 pandemic, with the goal of providing evidence to support strategies for improving emotional dist…
View article: Lipid metabolism genes AKR1B1 and PPARD as potential biomarkers of intervertebral disc degeneration and their correlation with immune infiltration
Lipid metabolism genes AKR1B1 and PPARD as potential biomarkers of intervertebral disc degeneration and their correlation with immune infiltration Open
View article: Comprehensive analysis of senescence-related genes and immune infiltration in intervertebral disc degeneration: a meta-data approach utilizing bulk and single-cell RNA sequencing data
Comprehensive analysis of senescence-related genes and immune infiltration in intervertebral disc degeneration: a meta-data approach utilizing bulk and single-cell RNA sequencing data Open
Objectives: This study aims to identify the key senescence genes and potential regulatory mechanisms that contribute to the etiology of intervertebral disc degeneration (IDD). Method: We analyzed GSE34095 and GSE70362 datasets, identifying…
View article: Immune-related gene IL17RA as a diagnostic marker in osteoporosis
Immune-related gene IL17RA as a diagnostic marker in osteoporosis Open
Objectives: Bone immune disorders are major contributors to osteoporosis development. This study aims to identify potential diagnostic markers and molecular targets for osteoporosis treatment from an immunological perspective. Method: We d…
View article: Trace4PF: A tool for Automated Decomposition of Problem Diagrams with Traceability
Trace4PF: A tool for Automated Decomposition of Problem Diagrams with Traceability Open
This paper provides a support tool for Jackson's Problem Frames approach -named Trace4PF for decomposing a global problem diagram into sub-problem diagrams.The tool provides a web browser interface with features such as drawing, editing an…
View article: BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study
BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study Open
Intervertebral disc degeneration (IDD) is the most common chronic skeletal muscle degeneration disease. Although the underlying mechanisms remain unclear, nucleus pulposus (NP) autophagy, senescence, and apoptosis are known to play a criti…
View article: Enhanced Uv-Shielding Ability and Mechanical Properties of Pla Through Compounded Functional Castor Oil-Based Polyurethane with Pla in Melt-Mixing
Enhanced Uv-Shielding Ability and Mechanical Properties of Pla Through Compounded Functional Castor Oil-Based Polyurethane with Pla in Melt-Mixing Open
View article: The Trends of Psychological Status of People Entering from High-Risk Areas of COVID-19 Coronavirus During the Quarantine in Dedicated Hotels: A Longitudinal Survey Study from Guangzhou, China
The Trends of Psychological Status of People Entering from High-Risk Areas of COVID-19 Coronavirus During the Quarantine in Dedicated Hotels: A Longitudinal Survey Study from Guangzhou, China Open
Yanhong Deng,1,* Lishuo Shi,2,* Jianxia Li,1,* Zhipeng Jiang,3,* Chaojun Xie,4 Shuangling Luo,3 Li Ling,5 Hualiang Lin,6 Zongqiu Chen,4 Yunlong Zhao,7 Liang Kang,3 Jun Yuan,4 Weiping Wen8 1Department of Medical Oncology, The Sixth Affiliat…
View article: FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway
FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway Open
Background Breast cancer (BC) is one of the most common cancers and the leading cause of death in women. Previous studies have demonstrated that FAM49B is implicated in several tumor progression, however, the role and mechanism of FAM49B i…
View article: Transcriptome research identifies four hub genes related to primary myelofibrosis: a holistic research by weighted gene co-expression network analysis
Transcriptome research identifies four hub genes related to primary myelofibrosis: a holistic research by weighted gene co-expression network analysis Open
EPB42, CALR, SLC4A1 and MPL were significantly highly expressed in PMF samples. These four genes may be considered as candidate prognostic biomarkers and potential therapeutic targets for early stage of PMF. The effects are worth expected …
View article: An Immune-Related Long Non-Coding RNA Signature to Predict the Prognosis of Ewing’s Sarcoma Based on a Machine Learning Iterative Lasso Regression
An Immune-Related Long Non-Coding RNA Signature to Predict the Prognosis of Ewing’s Sarcoma Based on a Machine Learning Iterative Lasso Regression Open
The aim of this study was to construct a new immune-associated long non-coding RNA (lncRNA) signature to predict the prognosis of Ewing sarcoma (ES) and explore its molecular mechanisms. We downloaded transcriptome and clinical prognosis d…
View article: Development of a Machine Learning-Based Autophagy-Related lncRNA Signature to Improve Prognosis Prediction in Osteosarcoma Patients
Development of a Machine Learning-Based Autophagy-Related lncRNA Signature to Improve Prognosis Prediction in Osteosarcoma Patients Open
Background Osteosarcoma is a frequent bone malignancy in children and young adults. Despite the availability of some prognostic biomarkers, most of them fail to accurately predict prognosis in osteosarcoma patients. In this study, we used …
View article: FAM49B Promotes Breast Cancer Proliferation, Metastasis , and Chemoresistance by Stabilizing ELAVL1 Protein and Regulating Downstream Rab10/TLR4 Pathway
FAM49B Promotes Breast Cancer Proliferation, Metastasis , and Chemoresistance by Stabilizing ELAVL1 Protein and Regulating Downstream Rab10/TLR4 Pathway Open
Background: Breast cancer (BC) is one of the most common cancers and the leading cause of death in women. Analysis of online databases revealed that FAM49B is highly expressed in BC and is associated with reduced disease-free survival (DF…
View article: Screening of osteoarthritis diagnostic markers based on immune-related genes and immune infiltration
Screening of osteoarthritis diagnostic markers based on immune-related genes and immune infiltration Open
View article: Development of a novel immune-related genes prognostic signature for osteosarcoma
Development of a novel immune-related genes prognostic signature for osteosarcoma Open
View article: Analysis of Immune Infiltration Pattern in Osteosarcoma and Its Clinical Significance
Analysis of Immune Infiltration Pattern in Osteosarcoma and Its Clinical Significance Open
ObjectiveOsteosarcoma (OS), the most common malignant bone tumor, is prone to early metastasis and recurrence, resulting in poor prognosis. The purpose of this study was to investigate gene expression in OS samples, and to study the relati…
View article: Trapezoidal Vertebral Body and Spine-Pelvis Sagittal Alignment in Patients with Lumber Spondylolisthesis
Trapezoidal Vertebral Body and Spine-Pelvis Sagittal Alignment in Patients with Lumber Spondylolisthesis Open
BACKGROUND Trapezoidal changes of the vertebral body are more common in patients with lumbar spondylolisthesis than in others. However, we lack an understanding of factors predisposing to the development of a marked trapezoidal deformity. …
View article: An immune-related gene signature for determining Ewing sarcoma prognosis based on machine learning
An immune-related gene signature for determining Ewing sarcoma prognosis based on machine learning Open
View article: Comparison of sagittal spinopelvic parameters in different types of double-level degenerative lumbar spondylolisthesis: a retrospective study
Comparison of sagittal spinopelvic parameters in different types of double-level degenerative lumbar spondylolisthesis: a retrospective study Open
Background Degenerative lumber spondylolisthesis (DLS), a common orthopaedic disease causing low back pain, seriously affects daily life and work. Although sagittal spinopelvic parameters have been studied in single-level DLS patients, inv…
View article: Identification of a novel autophagy-related gene signature for predicting metastasis and survival in patients with osteosarcoma
Identification of a novel autophagy-related gene signature for predicting metastasis and survival in patients with osteosarcoma Open
Background: Osteosarcoma (OS) is a bone malignant tumor that occurs in children and adolescents. Due to a lack of reliable prognostic biomarkers, the prognosis of OS patients is often uncertain. This study aimed to construct an autophagy-r…
View article: Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis Open
Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression …
View article: GRB10 and E2F3 as Diagnostic Markers of Osteoarthritis and Their Correlation with Immune Infiltration
GRB10 and E2F3 as Diagnostic Markers of Osteoarthritis and Their Correlation with Immune Infiltration Open
This study aimed to find potential diagnostic markers for osteoarthritis (OA) and analyze the role of immune cells infiltration in this pathology. We used OA datasets from the Gene Expression Omnibus database. First, R software was used to…
View article: Protein kinase A is involved in neuropathic pain by activating the p38MAPK pathway to mediate spinal cord cell apoptosis
Protein kinase A is involved in neuropathic pain by activating the p38MAPK pathway to mediate spinal cord cell apoptosis Open
The authors have withdrawn this preprint from Research Square
View article: <i>MCM2</i> and <i>NUSAP1</i> Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer
<i>MCM2</i> and <i>NUSAP1</i> Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer Open
Pancreatic cancer (PC) is one of the most malignant tumors. Despite considerable progress in the treatment of PC, the prognosis of patients with PC is poor. The aim of this study was to identify potential biomarkers for the diagnosis and p…
View article: Protein kinase A is involved in neuropathic pain by activating the p38MAPK pathway to mediate spinal cord cell apoptosis
Protein kinase A is involved in neuropathic pain by activating the p38MAPK pathway to mediate spinal cord cell apoptosis Open
Background: Neuropathic pain is a serious clinical problem to be solved. Protein kinase A (PKA) is widely distributed in the central nervous system and participates in various signal transduction pathways to regulate cell proliferation and…
View article: Slow skeletal muscle troponin T, titin and myosin light chain 3 are candidate prognostic biomarkers for Ewing's sarcoma
Slow skeletal muscle troponin T, titin and myosin light chain 3 are candidate prognostic biomarkers for Ewing's sarcoma Open
Ewing's sarcoma (ES) is a common malignant bone tumor in children and adolescents. Although great efforts have been made to understand the pathogenesis and development of ES, the underlying molecular mechanism remains unclear. The present …
View article: Cubic fitting method of wavelength shift of optical fiber grating temperature sensor and a temperature measuring device
Cubic fitting method of wavelength shift of optical fiber grating temperature sensor and a temperature measuring device Open
The center wavelength movement of fiber grating reflecting is not strictly linear relationship with the measured temperature due to the influence of grating materials, fiber materials, packaging and other factors. This makes the fiber Brag…
WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress Open
View article: 2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways
2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways Open
These findings suggest that 2-AG could maintain the GS expression in astrocytes to a relatively stable level through modulating MAPK signaling and protect astrocytes from LPS exposure.