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View article: The new oncogene transmembrane protein 60 is a potential therapeutic target in glioma
The new oncogene transmembrane protein 60 is a potential therapeutic target in glioma Open
Glioma is a malignant tumor with a high fatality rate, originating in the central nervous system. Even after standard treatment, the prognosis remains unsatisfactory, probably due to the lack of effective therapeutic targets. The family of…
View article: Development and validation of a preoperative MRI-based radiomics nomogram to predict progression-free survival in patients with clival chordomas
Development and validation of a preoperative MRI-based radiomics nomogram to predict progression-free survival in patients with clival chordomas Open
Objectives The aim of this study was to establish and validate a MRI-based radiomics nomogram to predict progression-free survival (PFS) of clival chordoma. Methods A total of 174 patients were enrolled in the study (train cohort: 121 case…
View article: GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1
GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1 Open
Cancer cells rewire their metabolism to meet the demands of growth and survival and this metabolic reprogramming has been recognized as an emerging hallmark of cancer. However, the respective mechanisms remain elusive and the contribution …
View article: Online calculator to predict early mortality in patient with surgically treated recurrent lower-grade glioma
Online calculator to predict early mortality in patient with surgically treated recurrent lower-grade glioma Open
View article: Preoperative Prediction of Meningioma Consistency via Machine Learning-Based Radiomics
Preoperative Prediction of Meningioma Consistency via Machine Learning-Based Radiomics Open
Objectives The aim of this study was to establish and validate a radiomics nomogram for predicting meningiomas consistency, which could facilitate individualized operation schemes-making. Methods A total of 172 patients was enrolled in the…
View article: Preoperative Predictors of Early Mortality Risk in Isocitrate Dehydrogenase-Wild-Type Glioblastoma Patients Treated with Standard Therapy
Preoperative Predictors of Early Mortality Risk in Isocitrate Dehydrogenase-Wild-Type Glioblastoma Patients Treated with Standard Therapy Open
Tumor location, preoperative elevated NLR and serum LDH level were independent predictors for 1-year mortality after GTR. We indicate that increased preoperative NLR or LDH may guide patients to review head magnetic resonance imaging (MRI)…
View article: Behavior-Oriented Nomogram for the Stratification of Lower-Grade Gliomas to Improve Individualized Treatment
Behavior-Oriented Nomogram for the Stratification of Lower-Grade Gliomas to Improve Individualized Treatment Open
Secondary glioblastomas (sGBM) are derived from previously lower-grade [World Health Organization (WHO) grades II or III] gliomas. Lower-grade benign-behaving gliomas may retain their former grade following recurrence, or may become malign…
View article: Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells Open
It has previously been reported that dihydroartemisinin (DHA) is an effective novel anticancer compound in a number of types of tumor cells. Previous studies have demonstrated the anticancer activity of DHA in gioma cells. However, its und…
View article: Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas
Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas Open
Our results indicated that FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for HGGs, which warrant further investigation.