Explanipedia

Impact du traitement par upadacitinib sur les biomarqueurs identifiés par la protéomique dans l’artérite à cellules géantes Open

Lisa Christ, Radhey Shyam Sharma, Thierry Sornasse, Yalan Bi, Hervé Guay , et al. · 2025

IsoTools 2.0: Software for Comprehensive Analysis of Long-read Transcriptome Sequencing Data Open

Yalan Bi, Tom Lukas Lankenau, Matthias Lienhard, Ralf Herwig · 2025

Direct, single molecule measurement of RNA by long-read transcriptome sequencing (LRTS) enables the reliable detection of transcripts and alternative splicing events, thus contributing to the identification of splicing mechanisms, improvem…

Isotools 2.0: Software for Comprehensive Analysis of Long-Read Transcriptome Sequencing Data Open

Yalan Bi, Tom Lukas Lankenau, Matthias Lienhard, Ralf Herwig · 2024

Expression Atlas update: insights from sequencing data at both bulk and single cell level Open

Nancy George, Silvie Fexová, Alfonso Munoz Fuentes, Pedro Madrigal, Yalan Bi , et al. · 2023

Expression Atlas (www.ebi.ac.uk/gxa) and its newest counterpart the Single Cell Expression Atlas (www.ebi.ac.uk/gxa/sc) are EMBL-EBI’s knowledgebases for gene and protein expression and localisation in bulk and at single cell level. These …

Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia Open

Feng Liu, Zhong‐Hao Wang, Wanjing Huang, Ying Xu, Xuan Sang , et al. · 2022

Strabismus and amblyopia are common ophthalmologic developmental diseases caused by abnormal visual experiences. However, the underlying pathogenesis and visual defects are still not fully understood. Most studies have used experimental in…

CD133, but Not CD44, May Serve as a Novel Biomarker for Differential Diagnosis Between Basal Cell Carcinoma and Trichoblastomas Open

Yalan Bi, Xiaohua Shi, Dian Chen, Yi Zhao · 2022

Our study expanded upon previous studies of CD133 and CD44 expressions in skin tumors, suggesting that CD133, but not CD44, may serve as a novel biomarker for differential diagnosis of BCC, although future studies using a larger number of …

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse Open

Wanjing Huang, Qiang Xu, Feng Liu, Jing Su, Dongchang Xiao , et al. · 2022

Ectopic expression occurs in the retina but not in the substantia nigra pars compacta in the DAT-tdTomato mouse, and fluorescently labeled cells in the retina are TPBG-expressing GABAergic ACs. This type of transgenic mice has been proved …

Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different Severities Open

Xu Li, Manik Garg, Tingting Jia, Qijun Liao, Lifang Yuan , et al. · 2022

Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in the progression stage, a detailed understanding of pertinent immune cells in recovered patients is lacking. We performed single-cell RNA …

Expression Atlas update: gene and protein expression in multiple species Open

Pablo Moreno, Silvie Fexová, Nancy George, Jonathan Manning, Zhichao Miao , et al. · 2021

The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a …

Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas Open

Wenhui Li, Wanjun Lei, Xiaopei Chao, Xiaochen Song, Yalan Bi , et al. · 2021

The association between human papillomavirus (HPV) integration and relevant genomic changes in uterine cervical adenocarcinoma is poorly understood. This study is to depict the genomic mutational landscape in a cohort of 20 patients. HPV+ …

Oncologic and obstetric outcomes after conization for adenocarcinoma in situ or stage IA1 cervical cancer Open

Xiaoyu Wang, Yalan Bi, Huanwen Wu, Ming Wu, Lei Li · 2020

The genomic profile of parathyroid carcinoma based on whole‐genome sequencing Open

Ya Hu, Xiang Zhang, Ou Wang, Yalan Bi, Xiaoping Xing , et al. · 2020

Parathyroid carcinoma (PC) is a rare endocrine malignancy with poor outcomes. Although some mutations such as CDC73 have been found in patients, the molecular mechanism of PC still needs extensive data to clarify. Whole‐genome sequencing (…

The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study Open

Xiaopei Chao, Ming Wu, Shuiqing Ma, Xianjie Tan, Sen Zhong , et al. · 2020

Successful management of nongestational ovarian choriocarcinoma complicated with choriocarcinoma syndrome: A case report and a literature review Open

Hongfa Peng, Lei Li, Yalan Bi · 2020

Nongestational ovarian choriocarcinoma (NGOC) accounts for <1% of ovarian germ cell tumors and may develop into the rare and fatal complication of choriocarcinoma syndrome. We reported a case of a 12-year-old girl with NGOC that metastasiz…

The effects of different instruments and suture methods of conization for cervical lesions Open

Xiaoyu Wang, Lei Li, Yalan Bi, Huanwen Wu, Ming Wu , et al. · 2019

Pathologically confirmed brain metastases from primary uterine cervical tumors: two cases and a literature review Open

Yalan Bi, Lei Li · 2019

Background Pathologically confirmed brain metastasis from primary cervical cancer is extremely rare. Herein, we report two cases of intracranial metastasis from cervical cancer that were histopathologically confirmed after surgical excisio…

Transcriptomic difference of thymoma and thymic carcinoma Open

Naixin Liang, L. Liu, H. Liu, W. Wang, Yalan Bi , et al. · 2019

Identification and injury to the inferior hypogastric plexus in nerve-sparing radical hysterectomy Open

Lei Li, Yalan Bi, Leiming Wang, Xinxin Mao, Bernhard Kraemer , et al. · 2019

Waterjet dissection of the inferior hypogastric plexus (IHP) resulted in a more rapid return of normal urodynamics than blunt dissection (control group) in patients who received laparoscopic nerve-sparing radical hysterectomy (NSRH) in a r…

Malignant transformation of vaginal adenosis to clear cell carcinoma without prenatal diethylstilbestrol exposure: a case report and literature review Open

Lihong Pang, Lei Li, Lan Zhu, Jinghe Lang, Yalan Bi · 2019

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China Open

Xiaopei Chao, Lei Li, Ming Wu, Shuiqing Ma, Xianjie Tan , et al. · 2019

Background The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated. Such data would be essential for the screening, prevention, genetic counselin…

Ovarian primary primitive neuroectodermal tumor: a review of cases at PUMCH and in the published literature Open

Xiaopei Chao, Yalan Bi, Lei Li · 2019

Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer Open

Minjiang Chen, Yan Xu, Jing Zhao, Wei Zhong, Li Zhang , et al. · 2019

Genome‑wide DNA methylation profile of thymomas and potential epigenetic regulation of thymoma subtypes Open

Yalan Bi, Yunxiao Meng, Yuchen Niu, Shanqing Li, Hongsheng Liu , et al. · 2019

The aim of the present study was to examine the whole‑genome DNA methylation status of thymomas and identify differences in thymoma DNA methylation profiles. DNA methylation profiles of tissues (n=12) were studied using the Infinium Methyl…

Concurrent Driver Gene Mutations as Negative Predictive Factors in EGFR Positive Non-Small Cell Lung Cancer Open

Minjiang Chen, Yan Xu, Jing Zhao, Wei Zhong, Li Zhang , et al. · 2019

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden Open

Tiantian Han, Ying Jin, Yan Li, Yalan Bi, Lingya Pan · 2018

In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically. In this retrospective study, women with vaginal adenosis between Janua…

Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas Open

Ming Cui, Ya Hu, Yalan Bi, Weiwei Wang, Mengyi Wang , et al. · 2018

Parathyroid carcinoma (PC) is a rare endocrine malignancy. Surgical resection is curative for local lesions, while effective therapies are lacking for recurrent or metastatic PCs. To study whether targeted therapies could be applied in rec…

Dramatic efficacy of dabrafenib in Erdheim-Chester disease (ECD): a pediatric patient with multiple large intracranial ECD lesions hidden by refractory Langerhans cell histiocytosis Open

Xiaolei Hao, Ruie Feng, Yalan Bi, Yuhan Liu, Chunde Li , et al. · 2018

Erdheim-Chester disease (ECD) is a rare non–Langerhans cell form of histiocytosis that can affect the central nervous system. ECD predominantly affects adults, and only a few pediatric cases have been reported. The co-occurrence of ECD and…

Co-Occurrence of Pheochromocytoma-Paraganglioma and Cyanotic Congenital Heart Disease: A Case Report and Literature Review Open

Bingbin Zhao, Yi Zhou, Yi Zhao, Yumo Zhao, Xingcheng Wu , et al. · 2018

Pheochromocytoma and paraganglioma (PHEO-PGL) and cyanotic congenital heart disease (CCHD) are both rare diseases. We reported a 30-year-old patient with a right adrenal gland nodule and a retroperitoneal mass and history of functional sin…

Castleman disease-associated diffuse parenchymal lung disease Open

Hui Huang, Ruie Feng, Li J, Xinyu Song, Shan Li , et al. · 2017

Intrathoracic involvement is common in Castleman disease (CD), but CD-associated diffuse parenchymal lung disease (DPLD) is rare and not well-reported.We conducted a retrospective analysis of 262 CD patients with a definite pathological di…

Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis Open

Chao Liu, En-Dong Liu, Yunxiao Meng, Xiaoming Dong, Yalan Bi , et al. · 2017

Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In…

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