Yubin Li
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View article: Spatial transcriptomics and single cell profiling reveal the dynamics of antigen presenting cancer associated fibroblasts during prostate cancer progression
Spatial transcriptomics and single cell profiling reveal the dynamics of antigen presenting cancer associated fibroblasts during prostate cancer progression Open
Prostate cancer (PCa) is characterized by an immunosuppressive "cold" tumor microenvironment (TME), contributing to therapy resistance. Cancer-associated fibroblasts (CAFs) are pivotal in shaping this TME, but their heterogeneity and spati…
View article: Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone
Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone Open
Introduction Several aquaporins (AQPs) are involved in the influx of water to form follicular fluid, and AQP2 may play a crucial role in follicular growth. However, the specific roles of Aquaporin (AQP) 2 and AQP6 in granulosa cells (GCs) …
View article: Highly Wear-Resistant Triboelectric Nanogenerators Based on Fluorocarbon-Graphene Hybrids
Highly Wear-Resistant Triboelectric Nanogenerators Based on Fluorocarbon-Graphene Hybrids Open
Triboelectric nanogenerators (TENGs) are pivotal for powering small electronic devices by converting mechanical energy into electrical energy. However, the wear resistance of TENG friction layers remains a critical barrier to their long-te…
View article: The safety and efficacy of complete preservation of internal iliac arteries in patients with aortoiliac aneurysms using iliac branch stent grafts: A multicenter retrospective comparative study
The safety and efficacy of complete preservation of internal iliac arteries in patients with aortoiliac aneurysms using iliac branch stent grafts: A multicenter retrospective comparative study Open
Objective The aim of study is to investigate the safety and efficacy of preserving bilateral internal iliac arteries (IIAs) in patients with aortoiliac aneurysms using iliac branch stent grafts (IBSG). Methods From June 2019 to February 20…
View article: Nucleoside reverse transcriptase inhibition enhances platelet production and megakaryocyte maturation in patients with <scp>COVID</scp>‐19
Nucleoside reverse transcriptase inhibition enhances platelet production and megakaryocyte maturation in patients with <span>COVID</span>‐19 Open
Summary Coronavirus disease 2019 (COVID‐19) is a systemic infection frequently involving the haematopoietic system. Thrombocytopenia is associated with increased risks of severe disease progression and mortality. Antiviral agents have show…
View article: Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation
Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation Open
In summary, this study demonstrates for the first time that the RAC1 activator DOCK2 regulates M1 macrophage polarisation and hepatic stellate cell activation to promote cholestasis-induced liver inflammation and fibrosis, suggesting that …
View article: A qualitative study of stigma in patients with low anterior resection syndrome of rectal cancer
A qualitative study of stigma in patients with low anterior resection syndrome of rectal cancer Open
Objective To investigate the real experience, influencing factors and coping method of stigma in patients with low anterior resection syndrome(LARS) of rectal cancer, and to provide reference for medical staff to formulate targeted interve…
View article: Optimization of lithium extraction solar pond in Zabuye Salt Lake: theoretical calculation combined with field experiments
Optimization of lithium extraction solar pond in Zabuye Salt Lake: theoretical calculation combined with field experiments Open
This research optimized the structure of lithium extraction solar ponds to enhance the crystallization rate and yield of Li2CO3. Using the response surface methodology in Design-Expert 10.0.3, the authors conducted experiments to investiga…
View article: Lidar Network for Temperature and Wind Measurements in the Mesosphere and Lower Thermosphere Region
Lidar Network for Temperature and Wind Measurements in the Mesosphere and Lower Thermosphere Region Open
A sodium lidar (light detection and range) network for the Earth's mesosphere and lower thermosphere (MLT) temperature, wind and sodium density measurements is designed and constructed in the second phase of the Chinese Meridional Project.…
View article: A symmetric heterogate dopingless electron-hole bilayer TFET with ferroelectric and barrier layers
A symmetric heterogate dopingless electron-hole bilayer TFET with ferroelectric and barrier layers Open
In this paper, a symmetric heterogate dopingless electron–hole bilayer tunnel field-effect transistor with a ferroelectric layer and a dielectric barrier layer (FBHD-EHBTFET) is proposed. FBHD-EHBTFET can not only avoid random doping fluct…
View article: IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease Open
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorders and cancer. Therefore, the …
View article: [Advances in Clinical Application of Cerebrospinal Fluid Circulating Tumor DNA
in Leptomeningeal Metastasis of Non-small Cell Lung Cancer].
[Advances in Clinical Application of Cerebrospinal Fluid Circulating Tumor DNA
in Leptomeningeal Metastasis of Non-small Cell Lung Cancer]. Open
Leptomeningeal metastasis (LM) is a lethal complication of malignant tumors, with an incidence rate of 3%-5% among patients with non-small cell lung cancer (NSCLC). LM poses significant challenges in diagnosis, has poor prognosis, limited …
View article: ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity
ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity Open
The appropriate transcriptional activity of PPARγ is indispensable for controlling inflammation, tumor and obesity. Therefore, the identification of key switch that couples PPARγ activation with degradation to sustain its activity homeosta…
View article: IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression
IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression Open
The spontaneous migration of bone marrow neutrophils (BMNs) is typically induced by distant tumor cells during the early stage of the tumor and critically controls tumor progression and metastases. Therefore, identifying the key molecule t…
View article: Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis Open
Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota–gut–brain axis. Ho…
View article: Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy
Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy Open
Background The aim of this study was to investigate the efficacy of bevacizumab (Bev) in reducing peritumoral brain edema (PTBE) after stereotactic radiotherapy (SRT) for lung cancer brain metastases. Methods A retrospective analysis was c…
View article: Supplementary Figures 1 through 12 from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer
Supplementary Figures 1 through 12 from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer Open
Supplementary Figure S1. The designed amino acid sequence of SIRPalphaD1-Fc. Supplementary Figure S2. Macrophage-mediated cytotoxicity in NSCLC cells after treatment with SIRPalphaD1-Fc. Supplementary Figure S3. SIRPalphaD1-Fc induced accu…
View article: Data from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer
Data from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer Open
CD47-specific antibodies and fusion proteins that block CD47–SIRPα signaling are employed as antitumor agents for several cancers. Here, we investigated the synergistic antitumor effect of simultaneously targeting CD47 and autophagy in non…
View article: Supplementary Figures 1 through 12 from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer
Supplementary Figures 1 through 12 from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer Open
Supplementary Figure S1. The designed amino acid sequence of SIRPalphaD1-Fc. Supplementary Figure S2. Macrophage-mediated cytotoxicity in NSCLC cells after treatment with SIRPalphaD1-Fc. Supplementary Figure S3. SIRPalphaD1-Fc induced accu…
View article: Data from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer
Data from Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer Open
CD47-specific antibodies and fusion proteins that block CD47–SIRPα signaling are employed as antitumor agents for several cancers. Here, we investigated the synergistic antitumor effect of simultaneously targeting CD47 and autophagy in non…
View article: Hsa_circ_0063329 inhibits prostate cancer growth and metastasis by modulating the miR-605-5p/tgif2 axis
Hsa_circ_0063329 inhibits prostate cancer growth and metastasis by modulating the miR-605-5p/tgif2 axis Open
Circular RNAs play crucial regulatory roles in the progression of various cancers. Nevertheless, the underlying mechanisms of circRNAs in prostate cancer (PCa) proliferation and metastasis remain largely uncertain. Here, we performed circR…