Yalda H. Ardakani
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View article: Innovative Chitosan‐Based Formulation for Controlled Release of Enrofloxacin: Pharmacokinetic Analysis in Rabbits
Innovative Chitosan‐Based Formulation for Controlled Release of Enrofloxacin: Pharmacokinetic Analysis in Rabbits Open
The present study was conducted to evaluate the pharmacokinetics (PK) of a novel triple‐layer formulation of enrofloxacin (ENR) compared to a conventional ENR formulation following subcutaneous (SC) administration in rabbits as an animal m…
View article: Investigating Myocardial Infarction's Impact on Cytochrome 2c19-Mediated Clopidogrel Activation During Acute and Subacute Phases: A Pharmacokinetic Protocol Study
Investigating Myocardial Infarction's Impact on Cytochrome 2c19-Mediated Clopidogrel Activation During Acute and Subacute Phases: A Pharmacokinetic Protocol Study Open
View article: Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach
Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach Open
The inter-individual variability of CYP450s enzyme activity may be reduced by comparing the effects of bariatric surgery on CYP-mediated drug elimination in comparable patients before and after surgery. The current research will use a low-…
View article: Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail Approach
Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail Approach Open
The inter-individual variability of CYP450s enzyme activity may be reduced by comparing the effects of bariatric surgery on CYP-mediated drug elimination in comparable patients before and after surgery. The current research will use a low-…
View article: A repurposed drug screen for regulating metabolic disease: an overview in the management of traumatic brain injury
A repurposed drug screen for regulating metabolic disease: an overview in the management of traumatic brain injury Open
Introduction & Background: The aim of this study is to review the mechanistic approaches and therapeutic opportunities in the management of traumatic brain injuries. Methods: A large numbe…
View article: Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after treatment, by using Geneva cocktail
Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after treatment, by using Geneva cocktail Open
The present study evaluates the influence of type 2 diabetes (T2D) on important CYP450 isoforms and P-glycoprotein (P-gp) transporter activities before and 3 months after intensifying treatment regimen of 40 patients. Results have been com…
View article: Variations in the Frequencies of Polymorphisms in the CYP450s Genes in Eight Major Ethnicities of Iran: A Review of the Human Data
Variations in the Frequencies of Polymorphisms in the CYP450s Genes in Eight Major Ethnicities of Iran: A Review of the Human Data Open
Genetic polymorphisms in cytochrome P450 genes can cause variation in metabolism. Thus, single nucleotide variants significantly impact drug pharmacokinetics, toxicity factors, and efficacy and safety of medicines. The distribution of CYP4…
View article: Enzyme and Thermo Dual-stimuli Responsive DOX Carrier Based on PNIPAM Conjugated Mesoporous Silica
Enzyme and Thermo Dual-stimuli Responsive DOX Carrier Based on PNIPAM Conjugated Mesoporous Silica Open
Background: Stimuli-responsive drug delivery systems have been proven to be a promising strategy to enhance tumor localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. Objectives: In this st…
View article: Extension of human GCSF serum half-life by the fusion of albumin binding domain
Extension of human GCSF serum half-life by the fusion of albumin binding domain Open
View article: Study the effect of 3,4-Methylenedioxy methamphetamine on cytochrome P450 2E1 activity
Study the effect of 3,4-Methylenedioxy methamphetamine on cytochrome P450 2E1 activity Open
Evaluating the effects of ecstasy on CYP2E1 activity is of great concern, mainly due to growing trends in abuse and co-administration of MDMA with ethanol and the dominant role of this isoenzyme on ethanol metabolism. This study aimed to e…
View article: Study the effect of 3,4-Methylenedioxy methamphetamine on cytochrome P450 2E1 activity
Study the effect of 3,4-Methylenedioxy methamphetamine on cytochrome P450 2E1 activity Open
Evaluating the effects of ecstasy on CYP2E1 activity is of great concern, mainly due to growing trends in abuse and co-administration of MDMA with ethanol and the dominant role of this isoenzyme on ethanol metabolism. This study aimed to e…
View article: Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data
Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data Open
Genetic polymorphisms in cytochrome P450 genes can cause alteration in metabolic activity of clinically important medicines. Thus, single nucleotide variants (SNVs) and copy number variations (CNVs) in CYP genes are leading factors of drug…
View article: Evaluation of phenoconversion phenomenon in obese patients: the effects of bariatric surgery on the CYP450 activity “a protocol for a case–control pharmacokinetic study”
Evaluation of phenoconversion phenomenon in obese patients: the effects of bariatric surgery on the CYP450 activity “a protocol for a case–control pharmacokinetic study” Open
View article: SN38 loaded nanostructured lipid carriers (NLCs); preparation and in vitro evaluations against glioblastoma
SN38 loaded nanostructured lipid carriers (NLCs); preparation and in vitro evaluations against glioblastoma Open
View article: Evaluation of Cinnamon (Cinnamomum Verum) Effects on Liver CYP450 2D1 Activity and Hepatic Clearance in Diabetic Rats
Evaluation of Cinnamon (Cinnamomum Verum) Effects on Liver CYP450 2D1 Activity and Hepatic Clearance in Diabetic Rats Open
Objectives: The present study assessed the effects of cinnamon on the activity of the liver CYP2D1 enzyme and hepatic clearance in the rat model of type 1 and 2 diabetes mellitus. Methods: Male Wistar rats were randomly categorized into 8 …
View article: Comparative Pharmacokinetics of Enrofloxacin After SubcutaneousAdministration of a Novel in situ Gel Forming Preparation and aConventional Product to Rabbits
Comparative Pharmacokinetics of Enrofloxacin After SubcutaneousAdministration of a Novel in situ Gel Forming Preparation and aConventional Product to Rabbits Open
BACKGROUND: Frequent drug dosing and animal handling are usually required in conventional antimicrobial therapy but sustained release formulations can improve compliance. OBJECTIVES: This study aimed to evaluate the pharmacokinetic (PK) pa…
View article: A comparative pharmacokinetic study of a novel sustained release danofloxacin formulation and the conventional product in rabbits.
A comparative pharmacokinetic study of a novel sustained release danofloxacin formulation and the conventional product in rabbits. Open
Sustained release drug formulations are frequently developed to reduce dosage frequency and to improve outcomes of drug therapy. This study evaluates the pharmacokinetic (PK) parameters of a novel injectable danofloxacin (DANO) formulation…
View article: Can combination therapy with insulin and metformin improve metabolic function of the liver, in type I diabetic patients? An animal model study on CYP2D1 activity
Can combination therapy with insulin and metformin improve metabolic function of the liver, in type I diabetic patients? An animal model study on CYP2D1 activity Open
View article: <b>Evaluation of the Association between Trough and Area Under the Curve to Minimum Inhibitory Concentration Ratio (AUC24/MIC) of Vancomycin in Infected Patients with Methicillin Resistant <i>Staphylococcus aureus</i> (MRSA)</b>
<b>Evaluation of the Association between Trough and Area Under the Curve to Minimum Inhibitory Concentration Ratio (AUC24/MIC) of Vancomycin in Infected Patients with Methicillin Resistant <i>Staphylococcus aureus</i> (MRSA)</b> Open
Background: The recent studies emphasized on the correlation of vancomycin antibacterial effect with pharmacokinetics properties such as the area under the curve/minimum inhibitory concentration (AUC24/MIC) ≥400 and serum trough level 15-2…
View article: Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol
Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol Open
Purpose: MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit i…
View article: Effect of 3,4-Methylenedioxymethamphetamine on Liver CYP2C19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe
Effect of 3,4-Methylenedioxymethamphetamine on Liver CYP2C19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe Open
Background and purpose: This study aimed at investigating the effects of 3,4-Methylenedioxymethamphetamine (MDMA) on liver cytochrome 2C19 enzyme activity, which is a major liver enzyme in the metabolism of a wide range of drugs, using o…
View article: Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin
Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin Open
View article: Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model.
Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model. Open
Results showed that despite the suppression of the CYP2C19 enzyme activity in T2DM rats, metformin treatment could increase the enzyme activity. Simultaneous application of cinnamon and metformin can modulate the function of CYP2C19 to the…
View article: Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case–control pharmacokinetic study
Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case–control pharmacokinetic study Open
View article: Validated analytical method for characterization of alcohols marketed in Tehran, Iran
Validated analytical method for characterization of alcohols marketed in Tehran, Iran Open
Background and objective: Various types of alcohol for severalapplications are available worldwide, of which, disinfection is one of the most important. In Muslim nations, consumption of alcoholic beverages is prohibited even at low quanti…
View article: Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacin
Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacin Open
The implantable drug products are developed mainly to sustain the drug release. This study was conducted to formulate and evaluate cross-linked films of chitosan/β-glycerophosphate (β-GP) for the sustained delivery of enrofloxacin (ENR). T…
View article: Gender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to CYP2D6 Phenotype in Iranian Population.
Gender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to CYP2D6 Phenotype in Iranian Population. Open
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of …
View article: Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model
Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model Open
All findings prove the inhibitory effects of ecstasy on both CYP2D6 and CYP3A4 hepatic isoenzymes. In conclusion, this study is the first investigation of MRZ metabolism in presence of MDMA in isolated perfused rat liver model.
View article: Preparation and in vitro evaluation of a novel chitosan-based hydrogel for injectable delivery of enrofloxacin
Preparation and in vitro evaluation of a novel chitosan-based hydrogel for injectable delivery of enrofloxacin Open
BACKGROUND: The development of injectable sustained-release products are of great interest to veterinary pharmaceuticals and animal health business. Recently, great attention has been paid to in situ gel-forming chitosan/beta-glycerophosph…
View article: Sensitive electrochemical determination of rifampicin using gold nanoparticles/poly-melamine nanocomposite
Sensitive electrochemical determination of rifampicin using gold nanoparticles/poly-melamine nanocomposite Open
Green and facile method for fabrication of a conductive polymer–Au nanocomposite platform as a novel electrochemical sensing layer for rifampicin.